Öz
Ground glass appearance is a nonspecific finding that can see in diseases such as chronic interstitial disease, acute alveolar disease or infection; however, it is most commonly encountered in COVID-19 pulmonary involvement today. The mammalian target of rapamycin (mTOR) plays a regulatory role in cell proliferation and growth. Everolimus is an allosteric mTOR inhibitor used in ER+ breast cancers and inhibits the mTOR functional complex. Here, we present a case of interstitial pneumonia due to everolimus, which can be confused with COVID-19 pneumonia due to its ground-glass appearance during the pandemic period.
Anahtar Kelimeler
Everolimus mTOR ground glass interstitial pneumonia Covid-19 breast cancer
Kaynakça
- Alhamad EH, Cosgrove GP. Interstitial lung disease: the initial approach. Med Clin North Am. 2011 Nov;95(6):1071-93. doi: 10.1016/j.mcna.2011.08.008.
- Parekh M, Donuru A, Balasubramanya R, Kapur S. Review of the chest CT differential diagnosis of ground-glass opacities in the COVID era. Radiology. 2020 Dec;297(3):E289-E302. doi: 10.1148/radiol.2020202504.
- Lee EYP, Ng MY, Khong PL. COVID-19 pneumonia: what has CT taught us? Lancet Infect Dis. 2020 Apr;20(4):384-385. doi: 10.1016/S1473-3099(20)30134-1.
- Matsuno O. Drug-induced interstitial lung disease: mechanisms and best diagnostic approaches. Respir Res. 2012 May 31;13(1):39. doi: 10.1186/1465-9921-13-39.
- Murugan AK. mTOR: Role in cancer, metastasis and drug resistance. Semin Cancer Biol. 2019 Dec;59:92-111. doi: 10.1016/j. semcancer.2019.07.003.
- Leung EY, Askarian-Amiri M, Finlay GJ, Rewcastle GW, Baguley BC. Potentiation of growth inhibitory responses of the mTOR inhibitor everolimus by dual mTORC1/2 inhibitors in cultured breast cancer cell lines. PLoS One. 2015 Jul 6;10(7):e0131400. doi: 10.1371/journal.pone.0131400.
- Lopez P, Kohler S, Dimri S. Interstitial lung disease associated with mTOR inhibitors in solid organ transplant recipients: Results from a large phase iii clinical trial program of everolimus and review of the literature. J Transplant. 2014;2014:305931. doi: 10.1155/2014/305931.
Öz
Kaynakça
- Alhamad EH, Cosgrove GP. Interstitial lung disease: the initial approach. Med Clin North Am. 2011 Nov;95(6):1071-93. doi: 10.1016/j.mcna.2011.08.008.
- Parekh M, Donuru A, Balasubramanya R, Kapur S. Review of the chest CT differential diagnosis of ground-glass opacities in the COVID era. Radiology. 2020 Dec;297(3):E289-E302. doi: 10.1148/radiol.2020202504.
- Lee EYP, Ng MY, Khong PL. COVID-19 pneumonia: what has CT taught us? Lancet Infect Dis. 2020 Apr;20(4):384-385. doi: 10.1016/S1473-3099(20)30134-1.
- Matsuno O. Drug-induced interstitial lung disease: mechanisms and best diagnostic approaches. Respir Res. 2012 May 31;13(1):39. doi: 10.1186/1465-9921-13-39.
- Murugan AK. mTOR: Role in cancer, metastasis and drug resistance. Semin Cancer Biol. 2019 Dec;59:92-111. doi: 10.1016/j. semcancer.2019.07.003.
- Leung EY, Askarian-Amiri M, Finlay GJ, Rewcastle GW, Baguley BC. Potentiation of growth inhibitory responses of the mTOR inhibitor everolimus by dual mTORC1/2 inhibitors in cultured breast cancer cell lines. PLoS One. 2015 Jul 6;10(7):e0131400. doi: 10.1371/journal.pone.0131400.
- Lopez P, Kohler S, Dimri S. Interstitial lung disease associated with mTOR inhibitors in solid organ transplant recipients: Results from a large phase iii clinical trial program of everolimus and review of the literature. J Transplant. 2014;2014:305931. doi: 10.1155/2014/305931.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | İç Hastalıkları |
| Bölüm | Case Reports |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Nisan 2022 |
| Gönderilme Tarihi | 24 Şubat 2022 |
| Kabul Tarihi | 9 Mart 2022 |
| Yayımlandığı Sayı | Yıl 2022 Cilt: 4 - Supplement 1 |
