The relationship between tumor necrosis factor α-308 G/A poly-morphism and serum tumor necrosis factor α levels in patients with migraine without aura

Yıl 2021, Cilt: 2 Sayı: 3, 73 - 78, 29.09.2021

Derya Tatlısuluoğlu , Eda Derle , Ruhsen Ocal , Seda Kibaroglu , Fatma Belgin Ataç , Ufuk Can

Öz

Objective: The aim of this study is to investigate the association of tumor necrosis factor (TNF) α-308 G/A genotype with migraine risk and the effect on serum TNF-α levels in patients with migraine without aura.
Methods: A total number of 70 patients with the diag-nosis of migraine without aura and 65 control subjects were included in this study. TNF-α level was studied from two separate blood samples taken from the pa-tient group during an attack and attack-free period separately and TNF-α-308 G/A genotype was studied once while one blood sample was taken for studying the TNF-α-308 G/A and TNF-α level genotype from the control group.
Results: The mean TNF-α level during an attack and attack-free periods were 13.58±2.84 pg/mL and 12.91±3.39 pg/mL, respectively in patients with mi-graine (n=70). This difference was statistically signifi-cant (p=0.033). The mean serum TNF-α level during an attack was 14.37±3.4 pg/mL in the migraine patients with G/A genotype (n= 38) and 12.79±1.54 pg/mL in those with A/A genotype (n=30); the difference be-tween the two groups was statistically significant (p=0.034). The effect of genotype distribution on mi-graine development was statistically significant (p=0.003).
Conclusion: TNF-α-308 G/A polymorphism is related to migraine in Turkish patients and TNF-α level in-creases during an attack compared with attack-free periods in patients with migraine without aura. Further studies are required for determining the relationship between TNF-α308 G/A polymorphism and TNF-α levels in the serum.

Anahtar Kelimeler

TNF-α, migraine, TNF-α-308 G/A polymorphism

Aurasız migrenlilerde tümör nekroz faktörü α-308 G/A polimorfizmi ve serum tümör nekroz faktörü α düzeyleri arasındaki ilişki

Öz

Amaç: Bu çalışmanın amacı, tümör nekroz faktör (TNF)-α 308 G/A genotipinin migren ile ilişkisini ve aurasız migrenlilerde serum TNF- α düzeyi üzerine etkisini araştırmaktır.
Yöntem: Bu çalışmaya aurasız migren tanılı 70 hasta ile migreni olmayan 65 kişiden oluşan kontrol grubu dahil edildi. Hasta grubunda TNF-α seviyesi biri atak biri ataksız dönemde olmak üzere alınan iki ayrı kan örneğinden ayrı ayrı çalışılmış, TNF-α 308 G/A geno-tipi ise bir kez çalışılmıştır. Kontrol grubunda da TNF-α seviyesi ve TNF-α 308 G/A genotipi birer kez çalı-şılmıştır.
Bulgular: Migren (n=70) grubunda ataklı ve ataksız dönemde TNF-α seviyesi sırasıyla 13.58±2.84 pg/mL ve 12.91±3.39 pg/mL idi. Bu fark istatistiksel olarak anlamlıydı (p=0.033). G/A genotipi olan migren hasta-larında (n=38) atak sırasında ortalama serum TNF-a seviyesi, 14.37±3.4 pg/mL ve A/A genotipi olanlarda (n=30) ise 12.79±1.54 pg/mL idi. İki grup arasındaki fark (p=0.034) istatiksel olarak anlamlıydı. Ayrıca genotip dağılımının migren gelişimi üzerindeki etkisi istatistiksel olarak anlamlı olarak bulundu (p=0.003).
Sonuç: TNF-α 308 G/A polimorfizmi, Türkiye’deki migren hastaları ile ilişkilidir ve aurasız migrenli has-talarda TNF- α seviyesi ataklı dönem ile ataksız dö-nemle karşılaştırıldığında artmaktadır. TNF-α 308 G/A polimorfizmi ile serumdaki TNF-α seviyeleri arasın-daki ilişkinin belirlenmesi için daha fazla çalışmalar gerekir.

Anahtar Kelimeler

TNF-α, migren, TNF-α 308 G/A polimorfizmi

Kaynakça

• 1. Ertas M, Baykan B, Orhan EK, et al. One-year preva-lence and the impact of migraine and tension-type headache in Turkey: A nationwide home-based study in adults. J Headache Pain 2012;13(2):147-57.
• 2. Puledda F, Messina R, Goadsby PJ. An update on migraine: Current understanding and future directions. J Neurol 2017;264(9):2031-39.
• 3. Goadsby PJ, Holland PR, Martins-Oliveira M, et al. Pathophysiology of migraine: A disorder of sensory processing. Physiol Rev 2017;97(2):553-622.
• 4. Horasanli B, Atac FB, Coven I, et al. Angiotensin I-converting enzyme gene (I/D) polymorphism in pati-ents with migraine. Headache 2013;53(1):161-64.
• 5. Martami F, Razeghi Jahromi S, Togha M, et al. The serum level of inflammatory markers in chronic and episodic migraine: A case-control study. Neurol Sci 2018;39(10):1741-49.
• 6. Erdener SE, Dalkara T. Modelling headache and migraine and its pharmacological manipulation. Br J Pharmacol 2014;171(20):4575-94.
• 7. Gu L, Yan Y, Long J, et al. The TNF-α-308G/A polymorphism is associated with migraine risk: A meta-analysis. Exp Ther Med 2012;3(6):1082-86.
• 8. Oliveira AB, Bachi ALL, Ribeiro RT, et al. Unbalan-ced plasma TNF-α and IL-12/IL-10 profile in women with migraine is associated with psychological and physiological outcomes. J Neuroimmunol 2017;313:138-44.
• 9. Yazici AC, Atac FB, Verdi H, et al. Comparison of IL10 and IL2 genotypes of Turkish population with other populations. Int J Immunogenet 2009;36(2):97-101.
• 10. Stuart S, Maher BH, Sutherland H, et al. Genetic variation in cytokine-related genes and migraine sus-ceptibility. Twin Res Hum Genet 2013;16(6):1079-86.
• 11. Rainero I, Grimaldi LM, Salani G, et al. Associa-tion between the tumor necrosis factor-alpha -308 G/A gene polymorphism and migraine. Neurology 2004;62(1):141-3.
• 12.Peng Y, Liu Y, Huang D, et al. Association of TNF-α-308(G/A) and -238(G/A) polymorphisms with non-traumatic osteonecrosis of the femoral head risks: A meta-analysis. Int Orthop 2018;42(7):1711-21.
• 13.Niu YM, Weng H, Zhang C, et al. Systematic review by multivariate meta-analyses on the possible role of tumor necrosis factor-α gene polymorphisms in asso-ciation with ischemic stroke. Neuromolecular Med 2015;17(4):373-84.
• 14. Liu J, Lian Z, Chen H, et al. Associations between tumor necrosis factor-α gene polymorphisms and the risk of Guillain-Barré syndrome and its subtypes: A systematic review and meta-analysis. J Neuroimmunol 2011;313:25-33.
• 15. El-Tahan RR, Ghoneim AM, El-Mashad N. TNF-α gene polymorphisms and expression. Springerplus 2016;5(1):1508.
• 16.Pinho-Ribeiro FA, Verri WA Jr, Chiu IM. Nocicep-tor sensory neuron-immune interactions in pain and inflammation. Trends Immunol 2017;38(1):5-19.
• 17. Yilmaz IA, Ozge A, Erdal ME, et al. Cytokine polymorphism in patients with migraine: Some sugges-tive clues of migraine and inflammation. Pain Med 2010;11(4):492-97.
• 18. Fawzi MS, El-Shal AS, Rashad NM, et al. Influence of tumor necrosis factor alpha gene promoter poly-morphisms and its serum level on migraine susceptibi-lity in Egyptian patients. J Neurol Sci 2015;348(1-2):74-80.
• 19. Mason BN, Russo AF. Vascular contributions to migraine: Time to revisit? Front Cell Neurosci 2018;12:233.
• 20. Rodriguez-Acevedo AJ, Smith RA, Roy B, et al. Genetic association and gene expression studies sug-gest that genetic variants in the SYNE1 and TNF genes are related to menstrual migraine. J Headache Pain 2014;15(1):62.
• 21. Chen M, Tang W, Hou L, et al. Tumor necrosis fac-tor (TNF) -308G>A, nitric oxide synthase 3 (NOS3)+894G>T polymorphisms and migraine risk: A Meta-Analysis. PLoS One 2015;10(6):e0129372.
• 22. Ghosh J, Joshi G, Pradhan S, Mittal B. Investiga-tion of TNFA 308G > A and TNFB 252G > A poly-morphisms in genetic susceptibility to migraine. J Neurol 2010;257(6):898-904.
• 23. Headache Classification Subcommittee of the In-ternational Headache Society. The International Classi-fication of Headache Disorders: 2nd edition. Cephalal-gia. 2004;24 Suppl 1:9-160.
• 24. Yılmaz Y, Verdi H, Taneri A, et al. Maternal-fetal proinflammatory cytokine gene polymorphism and preterm birth. DNA Cell Biol 2012;31(1):92-107.
• 25. Schürks M, Rist PM, Zee RY, et al. Tumour necrosis factor gene polymorphisms and migraine: A systematic review and meta-analysis. Cephalalgia 2011;31(13):1381-404.
• 26. Mazaheri S, Hajilooi M, Rafiei A. The G-308A promoter variant of the tumor necrosis factor-alpha gene is associated with migraine without aura. J Neurol 2006;253(12):1589-93.
• 27. Perini F, D'Andrea G, Galloni E, et al. Plasma cyto-kine levels in migraineurs and controls. Headache 2005;45(7):926-31.
• 28. Gallai V SP, Floridi A, Franceschini M, et al. Mo-nocyte function in migraine patients with and without aura. Headache Q 1994;214-27.
• 29. Sarchielli P, Alberti A, Baldi A, et al. Proinflamma-tory cytokines, adhesion molecules, and lymphocyte integrin expression in the internal jugular blood of migraine patients without aura assessed ictally. Hea-dache 2006;46(2):200-7.
• 30. Pappa S, Hatzistilianou M, Kouvatsi A, et al. Tumour necrosis factor gene polymorphisms and migra-ine in Greek children. Arch Med Sci 2010;6(3):430-7.
• 31.Uzar E, Evliyaoglu O, Yucel Y, et al. Serum cytoki-ne and pro-brain natriuretic peptide (BNP) levels in patients with migraine. Eur Rev Med Pharmacol Sci 2011;15(10):1111-16.