Vitaminlerin psikiyatrideki rolü: Bir gözden geçirme

Yavuz Yılmaz; Ali Erdoğan; Cicek Hocaoglu

Derleme

The role of vitamins in psychiatry: A review

Yıl 2022, Cilt: 3 Sayı: 1, 1 - 9, 31.01.2022

Yavuz Yılmaz , Ali Erdoğan , Cicek Hocaoglu

Öz

Genetic factors, stress, nutrition, medications and environ-mental variables are factors that affect the occurrence of psychiatric disorders. The effect of dietary nutrients on mental health is an area that attracted the attention of re-searchers and has been studied for over a century. The role of vitamins in psychiatric disorders is an issue that can be addressed within the nutritional factor. It has been known that some vitamin deficiencies can cause psychiatric symp-toms and disorders. The role of vitamins in the formation and treatment of schizophrenia, mood disorders, anxiety disorders, eating disorders and neurocognitive disorders has been investigated. When the literature is reviewed, it is seen that the data obtained from the studies in this field are not consistent. Especially, studies on the use of vitamin supplements in the treatment of these disorders have re-vealed conflicting results.

Anahtar Kelimeler

Psychiatry, vitamins, schizophrenia, depression, anxiety, neurocognitive disorders

Kaynakça

1. Hyman S, Chisholm D, Kessler R, Patel V, Whiteford H. Mental disorders. In: Jamison DT, Breman JG, Measham AR, Alleyne G, Claeson M, Evans DB et al. (Eds). Disease control priorities in developing countries. New York: Oxford University Press, 2006: 605-25.
2. Steel Z, Marnane C, Iranpour C, et al. The global preva-lence of common mental disorders: A systematic review and meta-analysis 1980–2013. Int J Epidemiol 2014;43(2):476-93.
3. Charlson FJ, Baxter AJ, Dua T, Degenhardt L, White-ford HA, Vos T. Excess mortality from mental, neurologi-cal and substance use disorders in the Global Burden of Disease Study 2010. Epidemiol Psychiatr Sci 2015;24(2):121-40.
4. Vigo D, Thornicroft G, Atun R. Estimating the true global burden of mental illness. The Lancet Psychiatry 2016; 3(2):171-8.
5. Hoobler BR. Symptomatology of Vitamin B deficiency in infants. JAMA 1928;91(5):307-10.
6. Reed GE. The use of manganese chloride as treatment in dementia præcox. Can Med Assoc J 1929;21(1):46.
7. Sydenstricker V, Cleckley H. The effect of nicotinic acid in stupor, lethargy and various other psychiatric disorders. American Journal of Psychiatry 1941;98(1):83-92.
8. Young LM, Pipingas A, White DJ, Gauci S, Scholey A. A systematic review and meta-analysis of B vitamin supp-lementation on depressive symptoms, anxiety, and stress: Effects on healthy and ‘at-risk’individuals. Nutrients 2019;1(9):2232.
9. Lim SY, Kim EJ, Kim A, Lee HJ, Choi HJ, Yang SJ. Nutritional factors affecting mental health. Clin Nutr Res 2016;5(3):143-52.
10. Belvederi Murri M, Respino M, Masotti M, et al. Vita-min D and psychosis: Mini meta-analysis. Schizophr Res 2013;150(1):235-9.
11. Casseb GAS, Kaster MP, Rodrigues ALS. Potential role of vitamin D for the management of depression and anxiety. CNS Drugs 2019;33(7):619-37.
12. Landel V, Annweiler C, Millet P, Morello M, Féron F. Vitamin D, cognition and Alzheimer's disease: The therape-utic benefit is in the D-tails. J Alzheimers Dis 2016;53(2):419-44.
13. Jamilian H, Amirani E, Milajerdi A, et al. The effects of vitamin D supplementation on mental health, and biomar-kers of inflammation and oxidative stress in patients with psychiatric disorders: A systematic review and meta-analysis of randomized controlled trials. Prog Neuropsyc-hopharmacol Biol Psychiatry 2019;94:109651.
14. Allott K, McGorry PD, Yuen HP, et al. The Vitamins in psychosis study: A randomized, double-blind, placebo-controlled trial of the effects of vitamins B(12), B(6), and folic acid on symptoms and neurocognition in first-episode psychosis. Biol Psychiatry 2019;86(1):35-44.
15. Kozyra M, Klas J, Szabat M, Samoń-Drzewicka AM, Milanowska J. The relationship between the diet, microele-ments, macronutrients and vitamins on the schizophrenia–literature analysis. J Educ Health Sport 2020;10(9):369-77.
16. Whiteford HA, Degenhardt L, Rehm J, et al. Global burden of disease attributable to mental and substance use disorders: Findings from the Global Burden of Disease Study 2010. The lancet 2013;382(9904):1575-86.
17. Bobo WV, Rapoport JL, Abi‐Dargham A, Fatemi SH, Meltzer HY. The neurobiology of schizophrenia. In: Tas-man A, Kay J, Lieberman JA, First MB, Riba MB (Eds). Psychiatry. New Jersey: John Wiley & Sons Ltd, 2015.
18. Goff DC, Bottiglieri T, Arning E, et al. Folate, ho-mocysteine, and negative symptoms in schizophrenia. Am J Psychiatry 2004;161(9):1705-8.
19. Herrán A, García-Unzueta MT, Amado JA, López-Cordovilla JJ, Díez-Manrique JF, Vázquez-Barquero JL. Folate levels in psychiatric outpatients. Psychiatry Clin Neurosci 1999;53(4):531-3.
20. Muntjewerff JW, Kahn RS, Blom HJ, den Heijer M. Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: A meta-analysis. Mol Psychiatry 2006;11(2):143-9.
21. Brown AS, Bottiglieri T, Schaefer CA, et al. Elevated prenatal homocysteine levels as a risk factor for schizoph-renia. Arch Gen Psychiatry 2007;64(1):31-9.
22. Roffman JL, Petruzzi LJ, Tanner AS, et al. Biochemi-cal, physiological and clinical effects of l-methylfolate in schizophrenia: A randomized controlled trial. Mol Psychi-atry 2018;23(2):316-22.
23. Firth J, Stubbs B, Sarris J, et al. The effects of vitamin and mineral supplementation on symptoms of schizophre-nia: A systematic review and meta-analysis. Psychol Med 2017;47(9):1515-27.
24. Eyles D, Brown J, Mackay-Sim A, McGrath J, Feron F. Vitamin D3 and brain development. Neuroscience 2003;118(3):641-53.
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Vitaminlerin psikiyatrideki rolü: Bir gözden geçirme

Yıl 2022, Cilt: 3 Sayı: 1, 1 - 9, 31.01.2022

Yavuz Yılmaz , Ali Erdoğan , Cicek Hocaoglu

Öz

Genetik faktörler, stres, beslenme, ilaçlar ve çevresel de-ğişkenler psikiyatrik bozuklukların oluşumunu etkileyen faktörlerdir. Diyetteki besin maddelerinin ruh sağlığına etkisi bir asır öncesinden beri araştırmacıların ilgisini çeken ve üzerinde çalışmalar yapılan bir alandır. Vitaminlerin psikiyatrik bozukluklardaki yeri, beslenme faktörü içerisin-de ele alınabilecek bir konudur. Bazı vitamin eksikliklerinin psikiyatrik belirti ve bozukluklara neden olabileceği bilin-mektedir. Şizofreni, duygudurum bozuklukları, anksiyete bozuklukları, yeme bozuklukları ve nörobilişsel bozukluk-ların oluşumunda ve tedavisinde vitaminlerin rolü araştırıl-mıştır. Literatüre bakıldığı zaman bu alanda yapılmış ça-lışmalardan elde edilen verilerin tutarlı olmadığı görülmek-tedir. Özellikle vitamin takviyelerinin bu bozuklukların tedavisinde kullanımı ile ilgili çalışmalar çelişkili sonuçlar ortaya çıkarmıştır.

Anahtar Kelimeler

Psikiyatri, vitaminler, şizofreni, depresyon, anksiyete, nörobilişsel bozukluklar

Kaynakça

1. Hyman S, Chisholm D, Kessler R, Patel V, Whiteford H. Mental disorders. In: Jamison DT, Breman JG, Measham AR, Alleyne G, Claeson M, Evans DB et al. (Eds). Disease control priorities in developing countries. New York: Oxford University Press, 2006: 605-25.
2. Steel Z, Marnane C, Iranpour C, et al. The global preva-lence of common mental disorders: A systematic review and meta-analysis 1980–2013. Int J Epidemiol 2014;43(2):476-93.
3. Charlson FJ, Baxter AJ, Dua T, Degenhardt L, White-ford HA, Vos T. Excess mortality from mental, neurologi-cal and substance use disorders in the Global Burden of Disease Study 2010. Epidemiol Psychiatr Sci 2015;24(2):121-40.
4. Vigo D, Thornicroft G, Atun R. Estimating the true global burden of mental illness. The Lancet Psychiatry 2016; 3(2):171-8.
5. Hoobler BR. Symptomatology of Vitamin B deficiency in infants. JAMA 1928;91(5):307-10.
6. Reed GE. The use of manganese chloride as treatment in dementia præcox. Can Med Assoc J 1929;21(1):46.
7. Sydenstricker V, Cleckley H. The effect of nicotinic acid in stupor, lethargy and various other psychiatric disorders. American Journal of Psychiatry 1941;98(1):83-92.
8. Young LM, Pipingas A, White DJ, Gauci S, Scholey A. A systematic review and meta-analysis of B vitamin supp-lementation on depressive symptoms, anxiety, and stress: Effects on healthy and ‘at-risk’individuals. Nutrients 2019;1(9):2232.
9. Lim SY, Kim EJ, Kim A, Lee HJ, Choi HJ, Yang SJ. Nutritional factors affecting mental health. Clin Nutr Res 2016;5(3):143-52.
10. Belvederi Murri M, Respino M, Masotti M, et al. Vita-min D and psychosis: Mini meta-analysis. Schizophr Res 2013;150(1):235-9.
11. Casseb GAS, Kaster MP, Rodrigues ALS. Potential role of vitamin D for the management of depression and anxiety. CNS Drugs 2019;33(7):619-37.
12. Landel V, Annweiler C, Millet P, Morello M, Féron F. Vitamin D, cognition and Alzheimer's disease: The therape-utic benefit is in the D-tails. J Alzheimers Dis 2016;53(2):419-44.
13. Jamilian H, Amirani E, Milajerdi A, et al. The effects of vitamin D supplementation on mental health, and biomar-kers of inflammation and oxidative stress in patients with psychiatric disorders: A systematic review and meta-analysis of randomized controlled trials. Prog Neuropsyc-hopharmacol Biol Psychiatry 2019;94:109651.
14. Allott K, McGorry PD, Yuen HP, et al. The Vitamins in psychosis study: A randomized, double-blind, placebo-controlled trial of the effects of vitamins B(12), B(6), and folic acid on symptoms and neurocognition in first-episode psychosis. Biol Psychiatry 2019;86(1):35-44.
15. Kozyra M, Klas J, Szabat M, Samoń-Drzewicka AM, Milanowska J. The relationship between the diet, microele-ments, macronutrients and vitamins on the schizophrenia–literature analysis. J Educ Health Sport 2020;10(9):369-77.
16. Whiteford HA, Degenhardt L, Rehm J, et al. Global burden of disease attributable to mental and substance use disorders: Findings from the Global Burden of Disease Study 2010. The lancet 2013;382(9904):1575-86.
17. Bobo WV, Rapoport JL, Abi‐Dargham A, Fatemi SH, Meltzer HY. The neurobiology of schizophrenia. In: Tas-man A, Kay J, Lieberman JA, First MB, Riba MB (Eds). Psychiatry. New Jersey: John Wiley & Sons Ltd, 2015.
18. Goff DC, Bottiglieri T, Arning E, et al. Folate, ho-mocysteine, and negative symptoms in schizophrenia. Am J Psychiatry 2004;161(9):1705-8.
19. Herrán A, García-Unzueta MT, Amado JA, López-Cordovilla JJ, Díez-Manrique JF, Vázquez-Barquero JL. Folate levels in psychiatric outpatients. Psychiatry Clin Neurosci 1999;53(4):531-3.
20. Muntjewerff JW, Kahn RS, Blom HJ, den Heijer M. Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: A meta-analysis. Mol Psychiatry 2006;11(2):143-9.
21. Brown AS, Bottiglieri T, Schaefer CA, et al. Elevated prenatal homocysteine levels as a risk factor for schizoph-renia. Arch Gen Psychiatry 2007;64(1):31-9.
22. Roffman JL, Petruzzi LJ, Tanner AS, et al. Biochemi-cal, physiological and clinical effects of l-methylfolate in schizophrenia: A randomized controlled trial. Mol Psychi-atry 2018;23(2):316-22.
23. Firth J, Stubbs B, Sarris J, et al. The effects of vitamin and mineral supplementation on symptoms of schizophre-nia: A systematic review and meta-analysis. Psychol Med 2017;47(9):1515-27.
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Toplam 102 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	Türkçe
Konular	Sağlık Kurumları Yönetimi
Bölüm	Makaleler
Yazarlar	Yavuz Yılmaz Ali Erdoğan Cicek Hocaoglu 0000-0001-6613-4317
Yayımlanma Tarihi	31 Ocak 2022
Gönderilme Tarihi	15 Haziran 2021
Yayımlandığı Sayı	Yıl 2022 Cilt: 3 Sayı: 1

Kaynak Göster

APA	Yılmaz, Y., Erdoğan, A., & Hocaoglu, C. (2022). Vitaminlerin psikiyatrideki rolü: Bir gözden geçirme. Troia Medical Journal, 3(1), 1-9.
AMA	Yılmaz Y, Erdoğan A, Hocaoglu C. Vitaminlerin psikiyatrideki rolü: Bir gözden geçirme. Troia Med J. Ocak 2022;3(1):1-9.
Chicago	Yılmaz, Yavuz, Ali Erdoğan, ve Cicek Hocaoglu. “Vitaminlerin Psikiyatrideki rolü: Bir gözden geçirme”. Troia Medical Journal 3, sy. 1 (Ocak 2022): 1-9.
EndNote	Yılmaz Y, Erdoğan A, Hocaoglu C (01 Ocak 2022) Vitaminlerin psikiyatrideki rolü: Bir gözden geçirme. Troia Medical Journal 3 1 1–9.
IEEE	Y. Yılmaz, A. Erdoğan, ve C. Hocaoglu, “Vitaminlerin psikiyatrideki rolü: Bir gözden geçirme”, Troia Med J, c. 3, sy. 1, ss. 1–9, 2022.
ISNAD	Yılmaz, Yavuz vd. “Vitaminlerin Psikiyatrideki rolü: Bir gözden geçirme”. Troia Medical Journal 3/1 (Ocak 2022), 1-9.
JAMA	Yılmaz Y, Erdoğan A, Hocaoglu C. Vitaminlerin psikiyatrideki rolü: Bir gözden geçirme. Troia Med J. 2022;3:1–9.
MLA	Yılmaz, Yavuz vd. “Vitaminlerin Psikiyatrideki rolü: Bir gözden geçirme”. Troia Medical Journal, c. 3, sy. 1, 2022, ss. 1-9.
Vancouver	Yılmaz Y, Erdoğan A, Hocaoglu C. Vitaminlerin psikiyatrideki rolü: Bir gözden geçirme. Troia Med J. 2022;3(1):1-9.

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