Epitelyal Over Kanserinde Retroperitoneal Lenf Nodu Metastazı Etkileyen Faktörlerin Araştırılması

Yıl 2017, Cilt: 20 Sayı: 2, 13 - 22, 08.03.2019

Hediye Dağdeviren , Ali İsmet Tekirdağ Özgür Akbayır

Öz

Amaç: Bu çalışmada, epitelyal over kanserli hastalarda lenf nodu tutulumu ile ilişkili faktörleri araştırıldı. Over kanserinin önemli
yayılım yollarından biri lenfatik yayılımdır. Bu tip yayılım sıklıkla ileri evrelerde görülür. Bu nedenle, over kanserinde lenf nodu
tutulumunu etkileyen faktörlerin belirlenmesi ve bu faktörlere yönelik yeni tedavi yöntemlerinin geliştirilmesi için elzemdir.
Gereç ve Yöntem: Çalışmamızda, son 10 yıl içerisinde Bakırköy Jinekoloji ve Pediatri eğitimi araştırma hastanesine başvuran ve
opere edilen over kanseri olgularını değerlendirildi ve tek merkezli ve homojen bir hasta grubunda klinik ve patolojik faktörler
olası lenf nodu tutulumu açısından araştırıldı.
Bulgular: Buna göre, preoperatif CA-125 protein seviyesi lenf nodu negatif olan hastalarda (469±954), pozitif olanlara göre
(1307±2937) anlamlı olarak daha düşük bulundu (p=0,004 <0,05). Ayrıca, CA-125 değeri ile hastalığın cerrahi evresi arasında
istatistiksel olarak anlamlı bir ilişki saptandı ve CA-125 düzeyi artışı ile lenf nodu tutulumunun arttığı tespit edildi (p<0.04). Bunun
yanında, preoperatif CA-125 yüksekliği ve omentum tutulumu ile lenf nodu tutulumu arasında pozitif ilişki tespit edildi, ancak
tümör histolojisi ve grade ile lenf nodu tutulumu arasında herhangi bir ilişki bulunmadı.
Sonuçlar: Çalışmadan elde edilen bulgular ışığında; Epitelyal over kanserinde lenfatik tutulum varlığı 5 yıllık sağ kalım açısından
önemli olduğu ve evre artışı ile lenfatik tutulum arasında pozitif korelasyon olduğu tespit edildi. Bu konuda yürütülecek tüm
risk faktörlerinin bir arada değerlendirildiği geniş serili çalışmalarla lenf nodu tutulumuna etki eden faktörlerin histopatolojik ve
moleküler etkileri aydınlatılabilir. 

Anahtar Kelimeler

Over kanseri, lenf nodları, metastaz

The Investigation of The Factors Affecting Retroperitoneal Lymph Node Metastasis In Epithelial Ovarian Cancer

Öz

Objective: In this study, the factors associated with lymph node involvement in patients with epithelial ovarian cancer were investigated. One of the major spreading ways of ovarian cancer is lymphatic spread. This type of spread is often seen in advanced
stages. Therefore, it is essential to determine the factors aff ecting lymph node involvement in ovarian cancer and to develop new
treatment methods for these factors.
Material and Method: In our study, the ovarian cancer cases who were admitted to Bakırköy Gynecology and Pediatrics Education Research Hospital and operated in the last 10 years were evaluated and clinical and pathological factors in terms of possible
lymph node involvement in a single-centered and homogeneous patient group were investigated.
Results: Accordingly, pre-operative CA-125 protein levels were signifi cantly determined lower in patients with negative lymph
node (469 ± 954) than those with positive lymph node (1307 ± 2937) (p = 0.004 <0.05). In addition, a statistically signifi cant relationship was detected between CA-125 value and the surgical stage of the disease and lymph node involvement was determined
to be increased with the increase in CA-125 level (p <0.04). Besides, a positive relationship was determined between high preoperative CA-125 levels and omentum involvement and lymph node involvement, but no relationship was found between tumor
histology and grade and lymph node involvement.
Conclusion: In the light of the fi ndings obtained from the study; it was detected that the presence of lymphatic involvement in
epithelial ovarian cancer was important for 5-year survival and that there was a positive correlation between the stage increase
and lymphatic involvement. The histopathological and molecular eff ects of factors aff ecting lymph node involvement can be
enlightened by a large series of studies in which all risk factors in this regard are evaluated together. 

Anahtar Kelimeler

Ovarian cancer, Lymph node, Metastasis

Kaynakça

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