Effects of Curcumin on The Changes in Some Acute Phase Proteins in Aflatoxin B1 Applied Rats

Yıl 2020, Cilt: 22 Sayı: 3, 384 - 388, 31.12.2020

Deniz Uluışık , Ercan Keskin , Durmuş Hatipoğlu

Öz

This research was carried out to evaluate the possible effects of curcumin on acute phase proteins in aflatoxin applied rats. In the study, 38 healthy male Wistar Albino rats were used. Group I animals was no applied. Animals in Group II were orally given 1 ml 10% DMSO daily for 60 days. Animals in Group III were orally given 300 mg/kg curcumin dissolved in 10% DMSO daily for 60 days. Animals in Group IV were orally given 250 µg/kg aflatoxin B1 dissolved in 10% DMSO daily for 60 days. Animals in Group V was orally given 250 µg/kg aflatoxin B1 dissolved in 10% DMSO and 300 mg/kg curcumin dissolved in 10% DMSO daily for 60 days. At the end of the study, nitric oxide, amyloid-A, haptoglobin and ceruloplasmin were determined in blood samples taken from all animals. In this study, nitric oxide, amyloid-A, haptoglobin and ceruloplasmin levels with aflatoxin B1 administration were found to be significantly higher than the control group (p<0.05). In the group in which aflatoxin and curcumin were administered together, nitric oxide, amyloid-A, haptoglobin and ceruloplasmin levels were lower than in the aflatoxin group (p<0.05). In conclusion, the obtained data indicated that administration of curcumin may be useful to alleviate the abnormalities in acute phase proteins resulting from aflatoxicosis.

Anahtar Kelimeler

Aflatoxin, Curcumin, Amyloid-A, Haptoglobin

Destekleyen Kurum

This study was supported by Selçuk University Scientific Research Projects Coordination Unit

Proje Numarası

Proje No: 18401138

Teşekkür

This study was supported by Selçuk University Scientific Research Projects Coordination Unit (Proje No: 18401138).

Kaynakça

• 1. Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol, 2009; 41(1): 40-59.
• 2. Ahmadi F. Effect of turmeric (Curcumin longa) powder on performance, oxidative stress state and some of blood parameters in broiler fed on diets containing aflatoxin B1. Global Veterinaria, 2010; 5(6): 312-317.
• 3. Apisariyakul A, Vanittanakom N, Buddhasukh D. Antifungal activity of turmeric oil extracted from Curcuma longa (Zingiberaceae). J Ethnopharmacol, 1995; 49(3): 163-169.
• 4. Appleton I, Tomlinson A, Willoughby DA. Induction of cyclo-oxygenase and nitric oxide synthase in inflammation. Adv Pharmacol, 1996; 35: 27-78.
• 5. Arora R, Kuhad A, Kaur IP, Chopra K. Curcumin loaded solid lipid nanoparticles ameliorate adjuvant-induced arthritis in rats. Eur J Pain, 2015; 19(7): 940-952.
• 6. Badolato R, Oppenheim JJ. Role of cytokines, acute-phase proteins and chemokines in the progression of rheumatoid arthritis. Semin Arthritis Rheum, 1996; 26(2): 526-538.
• 7. Banerjee M, Tripathi LM, Srivastava VM, Puri A, Shukla R. Modulation of inflammatory mediators by ibuprofen and curcumin treatment during chronic inflammation in rat. Immunopharmacol Immunotoxicol, 2003; 25(2): 213-224.
• 8. Bennett JW, Klich M. Mycotoxins. Clin Microbiol Rev, 2003; 16(3): 497-516.
• 9. Castells M, Marin S, Sanchis V, Ramos AJ. Distribution of fumonisins and aflatoxins in corn fractions during industrial cornflake processing. Int J Food Microbiol, 2008; 123(1-2): 81-87.
• 10. Channon KM, Guzik TJ. Mechanisms of superoxide production in human blood vessels: relationship to endothelial dysfunction, clinical and genetic risk factors. J Physiol Pharmacol, 2002; 53(4 Pt 1): 515-524.
• 11. Cray C, Zaias J, Altman NH. Acute phase response in animals: a review. Comp Med, 2009; 59(6): 517-526.
• 12. Cray C. Acute phase proteins in animals. Prog Mol Biol Transl Sci, 2012; 105: 113-150.
• 13. Cush JJ, Lipsky PE. Phenotypic analysis of synovial tissue and peripheral blood lymphocytes isolated from patients with rheumatoid arthritis. Arthritis Rheum, 1988; 31(10): 1230-1238.
• 14. Eckersall PD, Bell R. Acute phase proteins: Biomarkers of infection and inflammation in veterinary medicine. Vet J, 2010; 185(1): 23-27.
• 15. El-Agamy DS. Comparative effects of curcumin and resveratrol on aflatoxin B(1)-induced liver injury in rats. Arch Toxicol, 2010; 84(5): 389-396.
• 16. Ferreira FD, Kemmelmeier C, Arrotéia CC, da Costa CL, Mallmann CA, Janeiro V, Ferreira FM, Mossini SA, Silva EL, Machinski Jr M. Inhibitory effect of the essential oil of Curcuma longa L. and curcumin on aflatoxin production by Aspergillus flavus Link. Food Chem, 2013; 136(2): 789-793.
• 17. Floris G, Medda R, Padiglia A, Musci G. The physiopathological significance of ceruloplasmin. A possible therapeutic approach. Biochem Pharmacol, 2000; 60(12): 1735-1741.
• 18. Gorelick NJ. Risk assessment for aflatoxin: I. Metabolism of aflatoxin B1 by different species. Risk Anal, 1990; 10(4): 539-559.
• 19. Gruys E, Toussaint MJ, Niewold TA, Koopmans SJ. Acute phase reaction and acute phase proteins. J Zhejiang Univ Sci B, 2005; 6(11): 1045-1056.
• 20. Guzik TJ, Korbut R, Adamek-Guzik T. Nitric oxide and superoxide in inflammation and immune regulation. J Physiol Pharmacol, 2003; 54(4): 469-487.
• 21. Heinrich PC, Castell JV, Andus T. Interleukin-6 and the acute phase response. Biochem J, 1990; 265(3): 621-636.
• 22. Herlin T, Fogh K, Hansen ES, Andreasen A, Knudsen V, Henriksen TB, Bunger C, Kragballe K. 15-HETE inhibits Leukotriene B4 formation and synovial cell proliferation in experimental arthritis. Agents Action, 1990; 29: 52-53.
• 23. Huang MT, Lou YR, Ma W, Newmark HL, Reuhl KR, Conney AH. Inhibitory effects of dietary curcumin on forestomach, duodenal and colon carcinogenesis in mice. Cancer Res, 1994; 54(22): 5841-5847.
• 24. Irene II, Onyechi O. Effect of dietary incorporation of vernonia amygdalina. Del on AFB1 induced hepatotoxicity in weanling albino rats. Jamaican J Sci Technol, 2004; 15: 32-36.
• 25. Joe B, Lokesh BR. Role of capsaicin, curcumin and dietary n-3 fatty acids in lowering the generation of reactive oxygen species in rat peritoneal macrophages. Biochim Biophys Acta, 1994; 1224(2): 255-263.
• 26. Joe B, Rao UJ, Lokesh BR. Presence of an acidic glycoprotein in the serum of arthritic rats: Modulation by capsaicin and curcumin. Mole Cell Biochem, 1997; 169(1-2): 125-134.
• 27. Khattak S, Saeed-ur-Rehman, Shah HU, Ahmad W, Ahmad M. Biological effects of indigenous medicinal plants Curcuma longa and Alpinia galanga. Fitoterapia, 2005; 76(2): 254-257.
• 28. Kim EJ, Jeong SH, Cho JH, Ku HO, Pyo HM, Kang HG, Choi KH. Plasma haptoglobin and immunoglobulins as diagnostic indicators of deoxynivalenol intoxication. J Vet Sci, 2008; 9(3): 257-266.
• 29. Kröncke KD, Fehsel K, Suschek C, Kolb-Bachofen V. Inducible nitric oxide synthase-derived nitric oxide in gene regulation, cell death and cell survival. Int Immunopharmacol, 2001; 1(8): 1407-1420.
• 30. Kuby J. Leukocyte migration and inflammation. Immunology, 2nd Ed.; W.H. Freman and Company: New York, 1997; 357-378.
• 31. Kushner I, Mackiewicz A. Acute phase proteins as disease markers. Dis Markers, 1987; 5(1): 1-11.
• 32. Kwiecien S, Brzozowski T, Konturek PC, Konturek SJ. The role of reactive oxygen species in action of nitric oxide-donors on stress-induced gastric mucosal lesions. J Physiol Pharmacol, 2002a; 53(4 Pt 2): 761-773.
• 33. Kwiecien S, Brzozowski T, Konturek SJ. Effects of reactive oxygen species action on gastric mucosa in various models of mucosal injury. J Physiol Pharmacol, 2002b; 53(1): 39-50.
• 34. Leray V, Freuchet B, Bloc’h JL, Jeusette I, Torre C, Nguyen P. Effect of citrus polyphenol- and curcumin-supplemented diet on inflammatory state in obese cats. Brit J Nutr, 2011; 106: S198-S201.
• 35. Levy AP, Asleh R, Blum S, Levy NS, Miller-Lotan R, Kalet-Litman S, Anbinder Y, Lache O, Nakhoul FM, Asaf R, Farbstein D, Pollak M, Soloveichik YZ, Strauss M, Alshiek J, Livshits A, Schwartz A, Awad H, Jad K, Goldenstein H. Haptoglobin: basic and clinical aspects. Antioxid Redox Signal, 2010; 12(2): 293-304.
• 36. Mahfouz ME. Ameliorative effect of curcumin on aflatoxin B1- induced changes in liver gene expression of Oreochromis niloticus. Mol Biol (Mosk), 2015; 49(2): 313-324.
• 37. Medzhitov R. Origin and physiological roles of inflammation. Nature, 2008; 454(7203): 428-435.
• 38. Mogilnaya OA, Puzyr AP, Baron AV, Bondar VS. Hematological parameters and the state of liver cells of rats after oral administration of aflatoxin B1 alone and together with nanodiamonds. Nanoscale Res Lett, 2010; 5(5): 908-912.
• 39. Mohajeri M, Behnam B, Cicero AFG, Sahebkar A. Protective effects of curcumin against aflatoxicosis: A comprehensive review. J Cell Physiol, 2018; 233(4): 3552-3577.
• 40. Murphy PA, Hendrich S, Landgren C, Bryant CM. Food mycotoxins: an update. J Food Sci, 2006; 71(5): R51-R65.
• 41. Odeh M. Role of cytokines in rheumatoid arthritis. Drug News Perspect, 1998; 11(6): 331-341.
• 42. O'reilly EL, Eckersall PD. Acute phase proteins: a review of their function, behaviour and measurement in chickens. World's Poult Sci J, 2014; 70(1): 27-43.
• 43. Reddy AC, Lokesh BR. Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes. Mol Cell Biochem, 1992; 111(1-2): 117-124.
• 44. Reddy AC, Lokesh BR. Studies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygen species and the oxidation of ferrous iron. Mol Cell Biochem, 1994; 137(1): 1-8.
• 45. Reeta KH, Mehla J, Pahuja M, Gupta YK. Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats. Pharmacol Biochem Behav, 2011; 99: 399-407.
• 46. Richard JL. Some major mycotoxins and their mycotoxicoses-an overview. Int J Food Microbiol, 2007; 119(1-2): 3-10.
• 47. Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr, 2004; 92(3): 347-355.
• 48. Uhlar CM, Whitehead AS. Serum amyloid A, the major vertebrate acute-phase reactant. Eur J Biochem, 1999; 265(2): 501-523.
• 49. Van Boxel JA, Paget SA. Predominantly T-cell infiltrate in rheumatoid synovial membranes. N Engl J Med, 1975; 293(11): 517-520.
• 50. Venteclef N, Jakobsson T, Steffensen KR, Treuter E. Metabolic nuclear receptor signaling and the inflammatory acute phase response. Trends Endocrinol Metab, 2011; 22(8): 333-343.
• 51. Wigley P, Kaiser P. Avian cytokines in health and disease. Rev Bras Ciênc Avíc, 2003; 5(1): 1-14.
• 52. Yang RZ, Lee MJ, Hu H, Pollin TI, Ryan AS, Nicklas BJ, Snitker S, Horenstein RB, Hull K, Goldberg NH, Goldberg AP, Shuldiner AR, Fried SK, Gong DW. Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications. PLoS Med, 2006; 3(6): e287.