PRELIMINARY ASSESSMENT OF METAL LEVELS IN THALASSEMIA PATIENTS

Yıl 2017, Cilt: Volume 2 Sayı: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 18 - 18, 16.02.2017

Bayram Yüksel Dilek Kaya-akyüzlü Zeliha Kayaaltı

Öz

Studies due to biological screening in toxicological research are important
for the asssessment of human health risk considering environmental pollution.
Toxic metals are one of the serious groups of environmental contaminants.
Beta-thalassemia is a form of thalassemia that is caused by a deficiency of beta
globin related to any of more than 200 point mutations in functionally
important regions of the beta globin gene on chromosome 11. This deficiency
brings about an accumulation of unpaired α-globin chains and an inequality
between α and β globin chains, that develops an extensive range of thalassaemia
phenotypes including severe anemia and clinically asymptomatic individuals.
Iron is an essential element for many biological and cellular processes in a
trace amount, which is a part of numerous hemoproteins and non-heme iron
proteins. Differences in iron metabolism can alter lead toxicokinetics. Thus,
genes related to iron metabolism could modify lead toxicity.  From this point of view, the present study
intended to measure toxic and essentials metal levels in 100 genetically
unrelated thalassemia patients and 100 healthy unrelated controls. Hence, it
was also aimed to investigate whether or not iron-deficiency in
beta-thalassemia patients was associated with blood metal levels. Measurement
was performed by Atomic Absportion Spectrometry.  Finally, preliminary assessments of metal
levels in thalassemia patients were conducted.

 

This study was supported by the Scientific
and Technical Research Council of Turkey (TUBITAK), Project number 114S312.

Anahtar Kelimeler

PRELIMINARY ASSESSMENT OF METAL LEVELS IN THALASSEMIA PATIENTS

Kaynakça

• Ankara Police Forensic Laboratory, Turkish National Police, Ankara, Turkey
• Ankara University, Institute of Forensic Sciences, Dikimevi, Ankara, Turkey