THE IMPORTANCE OF IRON METABOLISM IN MITOCHONDRIA

Yıl 2017, Cilt: Volume 2 Sayı: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 291 - 291, 16.02.2017

Yasemin Kartal Zeliha Kayaaltı

Öz

Iron serves as
essential components play critical roles not only biochemical but also
physiological functions in the system.
Because it plays an important role in oxidative metabolism, cell growth,
transport of oxygen to tissues, DNA, RNA and protein synthesis due to act on
the structure and function of enzymes used in the catalysis of essential
reactions. Mitochondria, known as the powerhouse of the cell, play an important
role due to synthesis of iron sulfur clusters, prosthetic groups and heme
occurs in this organelle. Reactive
oxygen species (ROS) are formed by mitochondria in all aerobic organisms as a
product of normal metabolism. Production of ROS increase not only in case of
oxidative damage but also the presence of an iron value which above the
physiological limits. For example, β talasemi patients increased iron load
during therapy which is a result of excessive hemolysis, increased intestinal
iron absorption and frequent blood transfusions, causes organ damage and
dysfunction. Iron homeostasis is provided by iron regulatory proteins (IRPs) in
body. For example, IRP1 is sensitive to a variety of oxidative stress signals.
Oxidative stress and oxidative damage play an important role in early stages in
many pathophysiological processes such as neurodegeneration and specific
cancers. For this reason, iron homeostasis as an important factor in many
diseases and iron levels within the mitochondrion must be tightly regulated.
The relationship between each other mitochondrial dysfunction, iron
accumulation, and oxidative stress will be briefly summarized in this review.

 

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Anahtar Kelimeler

THE IMPORTANCE OF IRON METABOLISM IN MITOCHONDRIA

Kaynakça

• Yasemin KARTAL, Zeliha KAYAALTI
• Department of Physiology, Hacettepe University, Faculty of Medicine, Turkey. Department of Forensic Toxicology, Ankara University, Institute of Forensic Sciences, Turkey.