Cyclophosphamide (CP) is an alkylating cytotoxic drug commonly used clinically
for the treatment
of cancer and non-malignant diseases. However, high doses of CP causes blood and bone marrow toxicity. This study was conducted
to investigate the possible
protective effects of carvacrol (CAR), which is the basic component of essential oils and has antioxidant properties, in blood and bone marrow in experimental hematoxicity. In the study, 63 male Sprague-Dawley rats were divided into 9 groups as
7 animals in each group. After receiving
intracardiac blood from
animals under anesthesia, the bone marrow from the femur of the rats was carefully
removed. Intraperitoneal (i.p.) CP administration reduced leukocyte (77%, 86%), thrombocyte (30%, 35%) and bone marrow nucleated
cell counts (82%, 94%), respectively, parallel to the dose increase.
Leukocyte, thrombocyte and bone marrow nucleated cell counts in CP and 5 and 10 mg kg-1 CAR administered groups was significantly increased (p<0.001) compared to the CP alone. In the prevention of CP-induced myelosuppression and hematoxicity, 10 mg kg-1 CAR was more protective than 5 mg kg-1 CAR. The data suggest that by modifying the CAR dose at certain ratios, a
stronger protective effect against the
increased CP dose can
be achieved.
Birincil Dil | Türkçe |
---|---|
Bölüm | Araştırma Makalesi / Research Article |
Yazarlar | |
Yayımlanma Tarihi | 30 Haziran 2018 |
Yayımlandığı Sayı | Yıl 2018 Cilt: 5 Sayı: 2 |