Changing of Hemoglobin A1c Affects Mean Platelet Volume in Type-2 Diabetes Mellitus

Yıl 2016, Cilt: 2 Sayı: 1, 27 - 35, 01.01.2016

Huseyin Kurt , Davut Demirkiran

https://doi.org/10.5455/umj.20160211122820

Öz

Background: Mean platelet volume MPV level is known to increase in diabetes mellitus DM . Objective: In this study, the first aim is to examine whether there is a correlation between MPV and hemoglobin A1c HbA1c and fasting plasma glucose FPG . The second aim is to investigate whether a correlation exists between MPV and HbA1c and FPG changes after treatment Method: In the study, we examined baseline and final HbA1c, MPV and FPGA values of 343 patients. Including the study group SG consisted of 169 patients with diabetes whose HbA1c levels decreased %1 and the control group involving 174 patients whose HbA1c levels did not change. Results: Similar to CG, HbA1c level of SG decreased to 7.58, and MPV level reduced to 8.68. There existed a positive correlation between MPV and HbA1c levels r=154; p

Anahtar Kelimeler

Mean platelet volume, diabetes mellitus, hemoglobin A1c, fasting plasma glucose.

Kaynakça

• Demirtas L, Degirmenci H, Akbas EM, Ozcicek A, Timuroglu A, Gurel A, et al. Association of hematological indicies with diabetes, impaired glucose regulation and microvascular complications of diabetes. International journal of clinical and experimental medicine. 2015;8(7):11420-7.
• American Diabetes A. Diagnosis and classification of diabetes mellitus. Diabetes care. 2007;30 Suppl 1:S42-7.
• Gerich JE. Type 2 diabetes mellitus is associated with multiple cardiometabolic risk factors. Clinical cornerstone. 2007;8(3):53-68.
• Fox CS, Coady S, Sorlie PD, D'Agostino RB, Sr., Pencina MJ, Vasan RS, et al. Increasing cardiovascular disease burden due to diabetes mellitus: the Framingham Heart Study. Circulation. 2007;115(12):1544-50.
• Danaei G, Lawes CM, Vander Hoorn S, Murray CJ, Ezzati M. Global and regional mortality from ischaemic heart disease and stroke attributable to higher-than-optimum blood glucose concentration: comparative risk assessment. Lancet. 2006;368(9548):1651-9.
• Amin AA AW, Farrag AA. Impact of glycemic status on left ventricular systolic function in patients with acute coronary syndrome. Ulutas Med J. 2015;3(1):58-63.
• Buse JB, Ginsberg HN, Bakris GL, Clark NG, Costa F, Eckel R, et al. Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association. Diabetes care. 2007;30(1):162-72.
• Jeerakathil T, Johnson JA, Simpson SH, Majumdar SR. Short-term risk for stroke is doubled in persons with newly treated type 2 diabetes compared with persons without diabetes: a population-based cohort study. Stroke; a journal of cerebral circulation. 2007;38(6):1739-43.
• Shimodaira M, Niwa T, Nakajima K, Kobayashi M, Hanyu N, Nakayama T. Correlation between mean platelet volume and blood glucose levels after oral glucose loading in normoglycemic and prediabetic Japanese subjects. Journal of diabetes investigation. 2014;5(1):66-71.
• Colwell JA, Nesto RW. The platelet in diabetes: focus on prevention of ischemic events. Diabetes care. 2003;26(7):2181-8.
• Papanas N, Symeonidis G, Maltezos E, Mavridis G, Karavageli E, Vosnakidis T, et al. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets. 2004;15(8):475-8.
• Jindal S, Gupta S, Gupta R, Kakkar A, Singh HV, Gupta K, et al. Platelet indices in diabetes mellitus: indicators of diabetic microvascular complications. Hematology. 2011;16(2):86-9.
• Vinik AI, Erbas T, Park TS, Nolan R, Pittenger GL. Platelet dysfunction in type 2 diabetes. Diabetes care. 2001;24(8):1476-85.
• Herman WH, Fajans SS. Hemoglobin A1c for the diagnosis of diabetes: practical considerations. Polskie Archiwum Medycyny Wewnetrznej. 2010;120(1-2):37-40.
• Ismail-Beigi F, Craven T, Banerji MA, Basile J, Calles J, Cohen RM, et al. Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial. Lancet. 2010;376(9739):419-30.
• American Diabetes A. Standards of medical care in diabetes--2014. Diabetes care. 2014;37 Suppl 1:S14-80.
• Authors/Task Force M, Ryden L, Grant PJ, Anker SD, Berne C, Cosentino F, et al. ESC Guidelines on diabetes, pre- diabetes, and cardiovascular diseases developed in collaboration with the EASD: the Task Force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD). European heart journal. 2013;34(39):3035-87.
• Anderson RT, Narayan KM, Feeney P, Goff D, Jr., Ali MK, Simmons DL, et al. Effect of intensive glycemic lowering on health-related quality of life in type 2 diabetes: ACCORD trial. Diabetes care. 2011;34(4):807-12.
• Genuth S, Eastman R, Kahn R, Klein R, Lachin J, Lebovitz H, et al. Implications of the United kingdom prospective diabetes study. Diabetes care. 2003;26 Suppl 1:S28-32.
• Winocour PD. Platelets, vascular disease, and diabetes journal mellitus. pharmacology. 1994;72(3):295-303. of physiology and pharmacology. 1994;72(3):295-303
• Coban E, Kucuktag S, Basyigit S. Platelet activation in subjects with impaired glucose tolerance. Platelets. 2007;18(8):591-4.
• Coban E, Bostan F, Ozdogan M. The mean platelet volume in subjects with impaired fasting glucose. Platelets. 2006;17(1):67-9.
• Ulutas KT, Dokuyucu R, Sefil F, Yengil E, Sumbul AT, Rizaoglu H, et al. Evaluation of mean platelet volume in patients with type 2 diabetes mellitus and blood glucose regulation: a marker for atherosclerosis? International journal of clinical and experimental medicine. 2014;7(4):955-61.
• Demirtunc R, Duman D, Basar M, Bilgi M, Teomete M, Garip T. The relationship between glycemic control and platelet activity in type 2 diabetes mellitus. Journal of diabetes and its complications. 2009;23(2):89-94.
• Lippi G, Salvagno GL, Nouvenne A, Meschi T, Borghi L, Targher G. The mean platelet volume is significantly associated with higher glycated hemoglobin in a large population of unselected outpatients. Primary care diabetes. 2015;9(3):226-30.
• Kodiatte TA, Manikyam UK, Rao SB, Jagadish TM, Reddy M, Lingaiah HK, et al. Mean platelet volume in Type 2 diabetes mellitus. Journal of laboratory physicians. 2012;4(1):5-9.
• Shimodaira M, Niwa T, Nakajima K, Kobayashi M, Hanyu N, Nakayama T. Correlation between mean platelet volume and fasting plasma glucose levels in prediabetic and normoglycemic individuals. Cardiovascular diabetology. 2013;12:14.
• Hendra TJ, Oswald GA, Yudkin JS. Increased mean platelet volume after acute myocardial infarction relates to diabetes and to cardiac failure. Diabetes research and clinical practice. 1988;5(1):63-9.
• Skyler JS, Bergenstal R, Bonow RO, Buse J, Deedwania P, Gale EA, et al. Intensive glycemic control and the prevention of cardiovascular events: implications of the ACCORD, ADVANCE, and VA diabetes trials: a position statement of the American Diabetes Association and a scientific statement of the American College of Cardiology Foundation and the American Heart Association. Circulation. 2009;119(2):351-7.
• Han JY, Choi DH, Choi SW, Kim BB, Ki YJ, Chung JW, et al. Stroke or coronary artery disease prediction from mean platelet volume in patients with type 2 diabetes mellitus. Platelets. 2013;24(5):401-6.
• Dolasik I, Sener SY, Celebi K, Aydin ZM, Korkmaz U, Canturk Z. The effect of metformin on mean platelet volume in diabetic patients. Platelets. 2013;24(2):118-21.
• Vernekar PV, Vaidya KA. Comparison of mean platelet volume in type 2 diabetics on insulin therapy and on oral hypoglycaemic agents. Journal of clinical and diagnostic research : JCDR. 2013;7(12):2839-40.
• Kramer CK, Zinman B, Retnakaran R. Short-term intensive insulin therapy in type 2 diabetes mellitus: a systematic review and meta-analysis. The lancet Diabetes & endocrinology. 2013;1(1):28-34.