Ca2+ İyonları ile Çapraz Bağlı Sodyum Aljinat/-Karagenan Kürelerden Nifedipinin Kontrollü Salımı

Year 2024, Volume: 16 Issue: 1, 150 - 162, 31.01.2024

Gülcan Geyik

https://doi.org/10.29137/umagd.1384946

Abstract

Bu çalışmada, ağrı kesici olarak kullanılan Nifedipin ilacını kapsüllemek üzere sodyum aljinat/kappa-karagenan (NaAlg/-KRG) küreleri oluşturuldu. Küreler Fourier transform infrared (FTIR) spektroskopisi ile karakterize edildi ve çapları optik mikroskop kullanılarak ölçüldü. Elde edilen kürelerin pH 7,4 ve 1,2 tamponlarında şişme yüzdeleri ve ilaç salım profilleri incelendi. Kürelerin şişme yüzdeleri pH 1,2 bağırsak ortamında az iken, pH 7,4 mide ortamında daha fazla gerçekleşti. Ayrıca ilaç yüklü kürelerin; küre verimi, tutuklanma verimi ve ilaç yükleme yüzdeleri hesaplandı. İlaç salımı üzerine; NaAlg/-KRG (v/v) blend oranının, NF miktarının ve pH’nın etkisi incelendi. Nifedipinin kürelerden salımı pH 1,2 mide ortamında çok az iken pH 7,4 bağırsak ortamında kontrollü bir şekilde gerçekleşti. NaAlg/-KRG blendi içerisindeki -KRG miktarının ve pH’nın artması Nifedipin (NF) salımını artırdı, ilaç miktarının artması ise NF salımını azalttı. Salım kinetikleri pH 1,2 ortamında Fick Tipi, pH 7,4 ortamında Fick yasasına uymayan olarak gerçekleşti.

Keywords

Sodyum Aljinat, Blend, Nifedipin, Kappa-Karagenan

Controlled Release of Nifedipine from Sodium Alginate/-Carragenaan spheres

Abstract

In this study, sodium alginate/kappa-carrageenan spheres were formed by encapsulating the drug Nifedipine, which is used as a pain reliever. The spheres were characterized by Fourier transform infrared (FTIR) spectroscopy and their diameters were measured using an optical microscope. Swelling percentages and drug release profiles of the obtained spheres in pH 7.4 and 1.2 buffers were examined. The swelling percentages in the spheres were less in the intestinal environment at pH 1.2, while it was higher in the gastric environment at pH 7.4. In addition, the sphere yield, entrapment efficiency and drug loading percentages of drug-loaded spheres were calculated. On drug release; The effects of NaAlg/-KRG (v/v) blend ratio, NF amount and pH were investigated. The release of nifedipine from the spheres was minimal at pH 1.2 in the gastric environment, but in a controlled manner at pH 7.4 in the intestinal environment. Increasing the amount of -KRG and pH in the NaAlg/-KRG blend increased the release of Nifedipine (NF), while increasing the amount of drug decreased the release of NF.. Release kinetics were determined as Fick Type in pH 1.2 medium and non-Fick's Non-Fickian Transport aw in pH 7.4 medium.

Keywords

Sodium Alginate, Kappa-Carragenaan, Blend, Nifedipine

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