Reproduktif Sistemde ADAMTS Genleri

Yıl 2019, Cilt: 45 Sayı: 1, 111 - 118, 01.04.2019

Ziya Kalem , Müberra Namlı Kalem , Coşkun Şimşir

https://doi.org/10.32708/uutfd.504161

Cited By: 1

Öz

Güncel genetik
çalışmalarından ele edilen bilgilere göre pek çok gen çeşitli üreme organ ve
dokularında hayati rol oynamaktadır. Fertilitenin tüm makro- ve
mikro-süreçlerinde yoğun araştırmalar devam etmesine ve system çözülmeye
çalışılmasına rağmen, üreme sistemi patofizyolojisi halen tüm bilinmezliğiyle
karşımızda durmaktadır.  Ekstrasellüler matriks
(ECM) hücreler için yapısal bir destek olmasının yanısıra hücrenin şekli,
davranışı, diferansiasyonu, proliferasyonu, gen expresyonu ve hayatiyetleri
üzerinde  belirleyici rolü olan  fonksiyonel bir dokudur. “A Disintegrin-like And Metalloproteinase
with Thrombospondin type-1 motif” (ADAMTS)
proteinleri, ECM yapılarının yıkımından sorumlu, vücutta birçok fizyolojik ve
patolojik  süreçte önemli rolleri olan
çinko bağımlı proteinazlardır. Bu
derlemenin amacı üremenin patofizyolojisinde ADAMTS‘lerin rolleri üzerine
yapılmış çalışmaları biraraya getirerek konuyla ilgili geniş bir perspektif
sunmaktır.

Anahtar Kelimeler

ADAMTS, İmplantasyon, Ovulasyon, plasenta, preeklampsi

ADAMTS Genes in Reproductive System

Öz

Data of recent
genetic studies suggest a critical role of multiple genes in various
reproductive organs and tissues. Even though scrutinizing studies about all
macro- and microprocesses in fertility are yet being held, and the system is
trying to be untangled, the pathophysiology of repruduction remains an
appealing subject to research, which encircles the known sieged by unknown. The
extracellular matrix (ECM) is not only a structural support for the cells, but
also is a functional mesh which has determining role in cellular shapes,
behaviors, differentiation, proliferation, gene expressions, and their life
cycles. A disintegrin-like and metalloproteinase
with thrombospondin type-1 motif
(ADAMTS) proteins are a group of zinc-dependent metalloproteinases responsible
for degradation of ECM structures, which significantly act in many physiologic
and pathologic processes.  We aimed, in
this review, to pose a broad view about the pathophysiology of infertility
gathering the studies pertaining to matricellular proteins and ADAMTS enzymes
which participate in the riddle of matrix breakdown and renewal.

Anahtar Kelimeler

ADAMTS, ovulation, implantation, placenta, preeclampsia

Kaynakça

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