Postbiyotikler ve İnsülin Direnci

Yıl 2023, , 268 - 273, 30.12.2023

Betül Sarıdağ Devran , Mendane Saka

https://doi.org/10.52976/vansaglik.1261880

Öz

İnsan vücudu, yaşayan mikroorganizmalar için besin açısından zengin bir ortam sağlarken, kendisi için de bu yararlı mikroorganizmalar ya da onların metabolitleri tarafından bir dizi fayda sağlamaktadır. Probiyotikler genellikle "yeterli miktarlarda uygulandığında konakçıya sağlık yararları sağlayan canlı mikroorganizmalar" olarak tanımlanmaktadır. Probiyotik bakteriler tarafından salgılanan antimikrobiyal maddeler, postbiyotikler olarak kabul edilmekte ve gıdada patojen bakterilerin büyümesini engelleyerek, gıda güvenliğini sağlamakta ve insan sağlığını iyileştirmektedir. Kısa zincirli yağ asitleri (KZYA), mikrobiyal hücre duvarı parçaları, hücre dışı polisakkaritler, hücre lizatları, hücresiz süpernatanlar, teikoik asit, enzimler, vitaminler vb. postbiyotiklere örnek olarak verilebilir. Mikrobiyal türevli KZYA veya flavonoidler gibi postbiyotik örnekleri, konakçının beslenme davranışını, enerji metabolizmasını, insülin sekresyonunu ve insülin duyarlılığını doğrudan etkileyebilmektedir. Bugüne kadar postbiyotiklerin antidiyabetik, terapötik etkileri üzerine çok az araştırma yapılmış ve araştırma sonuçları arasında bazı tutarsızlıklar olmasına rağmen postbiyotiklerin insülin direnci, DM ve diğer metabolik hastalıklar için yeni terapötik ve önleyici yaklaşımlara kapı araladığı görülmektedir. İnsan sağlığı için terapötik etkiyi ortaya koyacak spesifik bir doz ayarlaması için postbiyotiklerin üzerinde daha çok çalışma yapılması gerekmektedir

Anahtar Kelimeler

probiyotik, postbiyotik, insülin direnci

Postbiotics and Insulin Resistance

Öz

Kaynakça

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