Determination of Median Values of First Trimester Screening Tests: A Tokat Scale Retrospective Study

Yıl 2019, Cilt: 12 Sayı: 2, 15 - 21, 29.12.2019

Muzaffer Katar

Öz

Objectives:
The aim of this study was to determine the ability of maternal serum plasma
protein A (PAPP-A) and free beta-human chorionic gonadotropin (free ß-hCG)
values ​​measured in the first trimester screening test to predict the
complications that may develop in later gestational weeks, calculate the median
values ​​of these parameters and compare them with those of software we use.

Materials and methods:
The study included 16-46 years old women who applied to biochemistry laboratory
of Tokat Gaziosmanpasa University School of Medicine with gestational ages of 10
weeks and 6 days to 13 weeks and 6 days. The results of 3166 pregnant women were
evaluated retrospectively.

Results:
The mean age of the patients was 27.43 ± 5.46 and their weight was 65.66 ±
13.13 kilograms. Crown rump lengthes (CRL) were determined as 60.71 ± 8.56 mm.
Free ß-hCG levels were 55.1 ± 132.07 ng / mL and PAPP-A values ​​were 3683.53 ±
2486 mIU / l. Nuchal translucency measurements (NT) were determined as 1.38 ±
0.37mm. PAPP-A and Free ß-hCG MoM values ​​were 1.23 ± 0.68 and 1.23 ± 0.88,
respectively. New median values ​​of β-hCG were found to be significantly lower
than those of the program (p <0.05), while PAPP-A values ​​were
significantly higher (p <0.05).

Conclusion:
The accuracy and performance of first trimester screening tests should be
improved. Determination of median values ​​specific to the region and even to
the laboratory is now inevitable

Anahtar Kelimeler

free ß-hCG, PAPP-A, Binary screening test

Destekleyen Kurum

There are no institutions supporting our study

Teşekkür

We would like to thank our all of the staff, especially our data processing staff, for their valuable contributions in the collection and processing of data for this study.

Birinci Trimester Tarama Testlerinin Medyan Değerlerinin Belirlenmesi: Tokat Ölçekli Retrospektif Bir Çalışma

Öz

Objectives:
The aim of this study was to determine the ability of maternal serum plasma
protein A (PAPP-A) and free beta-human chorionic gonadotropin (free ß-hCG)
values ​​measured in the first trimester screening test to predict the
complications that may develop in later gestational weeks, calculate the median
values ​​of these parameters and compare them with those of software we use.

Materials and methods:
The study included 16-46 years old women who applied to biochemistry laboratory
of Tokat Gaziosmanpasa University School of Medicine with gestational ages of 10
weeks and 6 days to 13 weeks and 6 days. The results of 3166 pregnant women were
evaluated retrospectively.

Results:
The mean age of the patients was 27.43 ± 5.46 and their weight was 65.66 ±
13.13 kilograms. Crown rump lengthes (CRL) were determined as 60.71 ± 8.56 mm.
Free ß-hCG levels were 55.1 ± 132.07 ng / mL and PAPP-A values ​​were 3683.53 ±
2486 mIU / l. Nuchal translucency measurements (NT) were determined as 1.38 ±
0.37mm. PAPP-A and Free ß-hCG MoM values ​​were 1.23 ± 0.68 and 1.23 ± 0.88,
respectively. New median values ​​of β-hCG were found to be significantly lower
than those of the program (p <0.05), while PAPP-A values ​​were
significantly higher (p <0.05).

Conclusion:
The accuracy and performance of first trimester screening tests should be
improved. Determination of median values ​​specific to the region and even to
the laboratory is now inevitable

Anahtar Kelimeler

free ß-hCG, PAPP-A, Double screening test

Kaynakça

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