Investigation of the Effects of Three Different Generations of Fluoroquinolone Derivatives on Erythrocyte Fragility and Hematological Parameters in Rats

Yıl 2023, Cilt: 16 Sayı: 3, 237 - 243, 30.12.2023

Fatih Donmez , Abdulahad Doğan

https://doi.org/10.52976/vansaglik.1330882

Öz

Objektive: Fluoroquinolones (FQs) are synthetic broad-spectrum antimicrobial agents derived from nalidixic acid. They are used in the treatment of urinary tract infections, respiratory tract infections, skin infections, digestive system infections, genital infections and other bacterial infections. Although the relationship between FQs and oxidative stress has been demonstrated, their effects on erythrocyte fragility have not been adequately studied. In this study, the effects of three different FQ derivatives (ciprofloxacin (CIP), levofloxacin (LVX) and moxifloxacin (MXF)) on erythrocyte fragility and hematological parameters were investigated in rats at the end of the 1st, 7th and 14th day treatments.
Material and Method: 72 Wistar albino male rats were divided into 4 groups with 18 rats in each group and sacrificed at three different time points (1st, 7th and 14th days).
Results: A significant increase in 0.2% sodium chloride (NaCl) concentration erythrocyte fragility value was found in the MXF group on 1st day compared to the control group on 1st day. While the FQ derivatives used in the study did not cause a general change on the erythrocyte and leukocyte parameters, they caused various fluctuations on the platelet parameters such as PCT, PLCR, PDW, MPW and PLT.
Conclusion: As a further study, it would be beneficial to reveal the reasons for these effects on platelet parameters with more detailed studies.

Anahtar Kelimeler

Erythrocyte fragility, Hematological parameters, Levofloxacin, Moxifloxacin, Ciprofloxacin

Destekleyen Kurum

This study was financially supported by Van Yuzuncu Yil University, Scientific Research Project Commission.

Proje Numarası

Project Number (TYL-2020–8809).

Teşekkür

We thank the Van Yüzüncü Yıl University Scientific Research Projects Commission for supporting this study.

Üç Farklı Kuşak Florokinolon Türevinin Ratlarda Eritrosit Frajilite ve Hematolojik Parametreler Üzerindeki Etkilerinin Araştırılması

Öz

Amaç: Florokinolonlar (FQ'lar), nalidiksik asitten türetilen sentetik geniş spektrumlu antimikrobiyal ajanlardır. Bu grup idrar yolu enfeksiyonları, solunum yolu enfeksiyonları, deri enfeksiyonları, sindirim sistemi enfeksiyonları, genital enfeksiyonlar ve diğer bakteriyel enfeksiyonların tedavisinde kullanılırlar. FQ'ların oksidatif stres ile ilişkisi gösterilmiş olmasına rağmen, eritrosit frajilite üzerindeki etkileri yeterince araştırılmamıştır. Bu çalışmada üç farklı florokinolon türevinin (siprofloksasin (CIP), levofloksasin (LVX) ve moksifloksasin (MXF)) 1, 7 ve 14 günlük tedavilerinin eritrosit frajilite ve hematolojik parametreler üzerindeki etkileri araştırıldı.
Materyal ve Metod: 72 Wistar albino erkek ratlar her grupta 18 rat olacak şekilde 4 gruba ayrılarak üç farklı zaman noktasında (1., 7. ve 14. günler) sakrifiye edildiler.
Bulgular: % 0.2 sodyum klorür (NaCl) konsantrasyonu eritrosit frajilite değeri 1. gün MXF grubu 1. gün kontrol grubu ile karşılaştırıldığında anlamlı artış göstermiştir. Çalışmada kullanılan FQ türevleri eritrosit ve lökosit parametrelerinde genel bir değişikliğe neden olmazken PCT, PLCR, PDW, MPW ve PLT gibi trombosit parametrelerinde çeşitli dalgalanmalara neden olmuştur.
Sonuç: İleri bir çalışma olarak trombosit parametreleri üzerindeki bu etkilerin nedenlerinin daha detaylı çalışmalarla ortaya konması faydalı olacaktır.

Anahtar Kelimeler

Eritrosit frajilite, Hematolojik parametreler, Levofloksasin, Moksifloksasin, Siprofloksasin

Proje Numarası

Project Number (TYL-2020–8809).

Kaynakça

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