Effects of Aflatoxin on Kidney and Protective Effectiveness of Esterified Glucomannan in Ram

Yıl 2017, Cilt: 28 Sayı: 1, 37 - 40, 20.04.2017

Fatma Çolakoğlu , Hasan Hüseyin Dönmez

Öz

In this study, the effects of total aflatoxin (AF) given orally on
kidney in Merino rams were studied. In addition, this study was conducted in
order to evaluate the efficacy of an esterified glucomannan (EG) for protection
against to aflatoxicosis. One year-old 32 Merino rams were divided into four
equal groups. Rams were fed through the 92 days. Control group (C) fed with the
commercial feed. AF group fed with commercial feed added 250 µg/day of total AF. EG group fed with commercial feed added 2
g/day of EG. AF+EG group fed with commercial feed added 250 µg/day of total AF
and 2 g/day of EG. At the end of the 92 day after cessation of the
animals, tissue samples were taken from the kidney in order to perform
histological structure. Degeneration and spills in the tubular epithelial cells
of kidney were observed in the AF group. Massive hyperemia was observed in the
renal vessels. In conclusion, the adverse effects causing by aflatoxicosis on
the kidney could be ameliorated by adding EG to the ration.

Anahtar Kelimeler

Aflatoxin, Glucomannan, Kidney Histology, Ram

Koçlarda Aflatoksinin Böbrek Üzerine Etkileri ve Esterifiye Glukomannanın Koruyucu Etkinliği

Öz

Bu
çalışmada Merinos ırkı koçlara ağızdan verilen total aflatoksinin (AF) böbrek
üzerine etkileri ile glukomannanın (EG) koruyucu etkinliği değerlendirildi.
Çalışmada 1 yaşında 32 adet koç 4 eşit gruba ayrıldı. Beslemeye 92 gün devam
edildi. Kontrol (K) grubuna ticari yem; AF grubuna ticari yem ile günlük 250 µg
AF; EG grubuna ticari yem ile günlük 2 gr EG; AF+EG grubuna ise ticari yemle
birlikte günlük 250 µg AF ve 2 gr EG verildi. 92. günün sonunda hayvanlar kesildikten sonra böbrekteki histolojik
yapıyı göstermek için örnekler alındı. AF grubunun böbrek tübüllerinde
dejenerasyon ve dökülmeler, böbrek damarlarında ise yoğun hiperemi gözlendi. Sonuç olarak; aflatoksikozun böbrek üzerindeki olumsuz
etkilerinin yeme EG ilave edilerek iyileştirilebildiği ortaya konmuştur.

Anahtar Kelimeler

Aflatoksin, Böbrek Histolojisi, Glukomannan, Koç

Kaynakça

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