DRUG USE AND TERATOGENITY IN PREGNANCY

Yıl 2022, Cilt: 13 Sayı: 2, 90 - 98, 31.08.2022

Sara Buşra Emiroğlu , Fatih Sakin

https://doi.org/10.38137/vftd.1082673

Öz

The pharmacokinetic properties of many drugs change due to the physiological changes shaped on the pregnant animals during pregnancy, so it is necessary to regulate the dosage regimen in pregnant. In addition, the existence of teratogenic effects of some drugs on the fetus or embryo limits the use of drugs in pregnant. Risk classification systems constituted to prevent these risks guide physicians. However, since these classification systems are not suitable for all species, their use is limited in the field of veterinary medicine and can provide an estimate for veterinarians about the harmful effects it may cause in other species. In this review, it is aimed to specify drug use, teratogenic drugs and their effects in pregnant, and also to guide veterinarians about drug use in pregnant patients.

Anahtar Kelimeler

Drug, pregnancy, teratogenicity

Teşekkür

Bu derleme 6th International Congress on Veterinary and Animal Sciences (ICVAS) 02-04 Eylül 2021 tarihinde özet bildiri olarak sunulmuştur.

GEBELİKTE İLAÇ KULLANIMI VE TERATOJENİTE

Öz

Gebelik sırasında annede şekillenen fizyolojik değişiklikler nedeniyle birçok ilacın farmakokinetik özelliği değişmekte, bu nedenle gebelerde dozaj rejimini düzenlemek gerekmektedir. Bunun yanında bazı ilaçların fetüs ya da embriyo üzerinde teratojenik etkilerinin varlığı gebelerde ilaç kullanımını sınırlandırmaktadır. Bu risklerin önüne geçmek amacıyla oluşturulan risk sınıflandırma sistemleri hekimlere rehberlik etmektedir. Ancak bu sınıflandırma sistemleri her tür açısından uygun olmadığı için özellikle veteriner hekimlik alanında kullanımı sınırlı olmakta ve diğer türlerde oluşturabileceği zararlı etkileri hakkında veteriner hekimlere bir tahmin sunabilmektedir. Bu derlemede gebelerde ilaç kullanımı, teratojenik ilaçlar ve etki şekillerini belirtmek, ayrıca veteriner hekimlerin gebe hastalarına ilaç kullanımı hakkında rehber olmak amaçlanmıştır.

Anahtar Kelimeler

Gebelik, ilaç, teratojenite

Kaynakça

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