VECTOR VACCINES FOR POULTRY

Yıl 2023, Cilt: 14 Sayı: 2, 98 - 107, 01.09.2023

Gazel Ayça Kurtbeyoğlu , Mehmet Akan

https://doi.org/10.38137/vftd.1273600

Öz

Vaccines are important in the control of the poultry diseases along with biosecurity measures. Today, vector vaccines which have lots of advantages compared to conventional vaccines stand out as a valuable alternative. In recombinant vector vaccine technology, antigens of various pathogens are delivered to another microorganism and the immune system of the vaccinated animal is stimulated by this vector. Viruses are frequently used in development of vector vaccines and bacteria or yeasts have also been preferred in some studies. For that purpose, viruses such as fowlpox virus (FPV), herpesvirus of turkeys (HVT), Newcastle disease virus (NDV), avian leukosis-sarcoma virus (ALSV) are selected as vectors. In addition to these viruses, some bacteria including Salmonella and Campylobacter have been used in some vaccine research. This review provides information on vector vaccines against various infectious diseases of poultry.

Anahtar Kelimeler

Immunity, poultry, vaccine, vector vaccine

KANATLI HAYVANLARDA KULLANILAN VEKTÖR AŞILAR

Öz

Aşılar, kanatlı hayvan hastalıklarının kontrolünde biyogüvenlik uygulamaları ile birlikte önemli bir yere sahiptir. Günümüzde konvansiyonel aşılara ilave olarak özellikle tavuklarda vektör aşıların kullanımında önemli bir artış görülmektedir. Rekombinant aşı teknolojisinde patojenlere ait antijenleri kodlayan genler başka bir mikroorganizmaya aktarılmakta ve aşının uygulandığı hayvanın bağışıklık sistemi, bu antijenlerle uyarılmaktadır. Vektör aşıların oluşturulmasında sıklıkla viruslar kullanılmakta olup bakteriler ya da mayaların tercih edildiği çalışmalar da bulunmaktadır. Bu amaçla, tavuk çiçeği virusu (FPV), Hindi Herpesvirusu (HVT), Newcastle hastalığı virusu (NDV), Avian Lökozis Sarkoma Virusu (ALSV) gibi viruslar vektör olarak seçilmektedir. Bu virusların yanı sıra Salmonella ve Campylobacter gibi kimi bakterilerin vektör olarak kullanıldığı aşı araştırmaları da yapılmıştır. Bu derlemede kanatlı hayvanlar hastalıklarına yönelik geliştirilen vektör aşılarla ilgili bilgiler verilmiştir.

Anahtar Kelimeler

Aşı, bağışıklık, kanatlı, vektör aşı

Kaynakça

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