Araştırma Makalesi
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Ailevi Akdeniz Ateşi Olan 40 Gebenin Perinatal Sonuçları

Yıl 2018, Cilt: 49 Sayı: 1, 77 - 79, 05.03.2018
https://doi.org/10.16948/zktipb.333212

Öz

Amaç
:
Ailevi
Akdeniz Ateşi (AAA)  tanısı olan, gebe  olguların maternal ve fetal sonuçlarının
değerlendirilmesi amaçlanmıştır.

 

Gereç ve Yöntem :
Çalışmamız 2013-2017 yılları arasında üniversitemizin perinataloji kliniğinde
gebelikleri takip edilmiş 40 AAA olgusunun dosya verilerinin retrospektif olarak
incelenmesiyle yapıldı. Hastaların klinik özellikleri , obstetrik ve perinatal
sonuçları değerlendirildi.

 

Bulgular:
Ortalama
hasta yaşı 30.75 ±6.15, nulliparite oranı %42,5 bulundu. Ortalama hastalık
süresi 8,36 ± 5.44 yıl olarak bulundu. Gebelik sırasında 7 hasta atak geçirdi.
Hastaların % 90 ’ ı medikal tedavi almaktaydı. Ortalama doğum haftası 37,3±4.5,
ortalama doğum kilosu 3115±547  gr
bulundu. Preterm doğum, fetal büyüme kısıtlılığı  ,preeklampsi görülme oranları sırasıyla; %10 ,
%5 , %10, olarak bulundu. Fetal ve neonatal kayıp, ile konjenital anomalili
doğum gözlenmedi.

 













Sonuç  : AAA tanılı gebelik
olgularının yönetiminde multidisipliner yaklaşım ile takip ve tedavinin
sağlanması olumlu  maternal ve fetal
sonuçlar ile ilişkilidir.

Kaynakça

  • 1 Dormer AE, Hale JF. Familial Mediterranean fever: a cause of periodic fever Br. Med J. 1962 Jan ; 13 (1) :87-9
  • 2 Ben-Chetrit E, Levy M. Familial Mediterranean fever. Lancet 1998 Feb ;28 (351):659-64
  • 3 Ben-Chetrit E, Levy M. Reproductive system in Familial Mediterranean fever: an overview. Ann Rheum Dis 2003 Oct ; 62 (10) :916–9.
  • 4 Mijatovic V, Hompes PG, Wouters MG. Familial Mediterranean fever and its implications for fertility and pregnancy. Eur J Obstet Gynecol Reprod Biol 2003 Jun ; 10 (108):171–6
  • 5 Tunca M, Akar S, Onen F, Ozdogan H, Kasapcopur O, Yalcinkaya F et al. Familial Mediterranean fever ) in Turkey: results of a nationwide multicenter study. Medicine 2005 Jan; 84 (1):1–11. 
 6 Cobankara V, Fidan G, Turk T, Zencir M, Colakoglu M, Ozen S The prevalence of familial Mediterranean fever in the Turkish province of Denizli: a field study with a zero patient design. Clin Exp Rheumatol 2004 Jul-Aug; 22 (4): 27–30.
  • 7 Michael O, Goldman RD, Koren G. Safety of colchicine therapy during pregnancy. Can Fam Physician 2003 Aug; 49 :967–9.
  • 8 Ben chetrit E, Levy M, Colchicine: 1998 update. Semin Arthritis Rheum 1998 Aug ;28 (1):48–59.
  • 9 Berkenstadt M, Weisz B, Cuckle H, Di-Castro M, Guetta E, Barski G. Chromosomal abnormalities and birth defects among couples with colchicine treated Familial Mediterranean fever. Am J Obstet Gynecol 2005 Oct ;193 (4):1513–6
  • 10 Ditkoff EC,Sauer MV.Successful pregnancy in a Familial Mediterranean fever patient following assisted reproduction. J Assist Reprod Genet 1996 Sep ;13 (8):684– 5.
  • 11 Rabinovitch O, Zemer D, Kukua E, Sohar E, Mashiach S.Colchicine treatment in conception and pregnancy: 231 pregnancies with Familial Mediterranean fever. Am J Repord Immunol 1992 Oct - Dec ; 28 (3–4):245–6.
  • 12 Zemer D, Pras M, Sohar E, Modan M,Cabili S, Gafni J. Colchicine in the prevention and 
treatment of the amyloidosis of familial Mediterranean fever. 
N Engl J Med 1986 Apr ;314 (16):1001–3.
  • 13 Ofir D, Levy A, Wiznitzer A, Mazor M, Sheiner E Familial Mediterranean fever : An independent risk factor for preterm delivery European Journal of Obstetrics & Gynecology and Reproductive Biology 2008 Dec;141 (2) :115–118 14 Yasar 0, Iskender C, Kaymak O, Yaman TS, Uygur D, Danısman N Retrospective evaluation of pregnancy outcomes in women with familial Mediterranean fever J Matern Fetal Neonatal Med 2014 May; 27(7): 733–736 
 15 Ben-Cherit E, Ben-Cherit A, Berkun Y, Ben-Cherit E Pregnancy outcomes in women with familial Mediterranean fever receiving colchicine: is amniocentesis justified? Arthritis Care Res 2010 Feb; 62(2):143–148
  • 16 Ehrenfeld M, Brzezinski A, Levy M, Eliakim M. Fertility and obstetric history in patients with familial Mediterranean fever on long-term colchicine therapy. Br J Obstet Gynaecol 1987 Dec; 94 (12):1186-91.
  • 17 Ben-Chetrit E, Levy M. Colchicine prophylaxis in familial Mediterranean fever: reappraisal after 15 years. Semin Arthritis Rheum 1991 Feb; 20 (4):241-6.
  • 18 Berkenstadt M, Weisz B, Cuckle H, Di-Castro M, Guetta E, Barkai G. Chromosomal abnormalities and birth defects among couples with colchicine treated familial Mediterranean fever. Am J Obstet Gynecol 2005 Oct ;193 (4):1513-6.
  • 19 Venhoff N,Voll RE, Glaser C, Thiel J IL-1-blockade with Anakinra during pregnancy : Retrospective analysis of efficacy and safety in female patients with familial Mediterranean fever Z Rheumatol 2017 Jul ; Epub ahead of print
  • 20 Ilgen U, Küçükşahin O Anakinra use during pregnancy: Report of a case with Familial Mediterranean Fever and infertility. Eur J Rheumatol 2017 Mar ; Epub ahead of print

Perinatal Outcomes of 40 Pregnancies with Familial Mediterranean Fever

Yıl 2018, Cilt: 49 Sayı: 1, 77 - 79, 05.03.2018
https://doi.org/10.16948/zktipb.333212

Öz




Objective
:
To
evaluate maternal and fetal outcomes of  
pregnancies diagnosed with Familial
Mediterranean Fever (FMF)




Methods
:
  Retrospective analysis of 40 pregnancies
diagnosed with FMF who received antenatal care at our perinatology unit between
2012 -2017 included in this clinical study. Clinical characteristics of
patients, perinatal and maternal outcomes were evaluated.




Results
:
The
mean patient age was 30.75 ±6.15 and the nulliparity rate was 42,5 %. The mean
duration of illness was found to be 8,36 ± 5.44 years. 7 patients had an attack
during pregnancy.
90 % of the patients received medical treatment. Mean gestational
age at delivery was
37,3±4.5 ,  mean birth weight was 3115±547 g.  Preterm delivery, fetal
growth restriction and 
preeclampsia
rates were 10, 5, 10 % respectively.
Fetal and neonatal loss, congenital
anomalous birth was not observed.




Conclusion:
Multidisciplinary approach to the care of 
pregnancy diagnosed with FMF  is
associated with good maternal and fetal outcomes.




Kaynakça

  • 1 Dormer AE, Hale JF. Familial Mediterranean fever: a cause of periodic fever Br. Med J. 1962 Jan ; 13 (1) :87-9
  • 2 Ben-Chetrit E, Levy M. Familial Mediterranean fever. Lancet 1998 Feb ;28 (351):659-64
  • 3 Ben-Chetrit E, Levy M. Reproductive system in Familial Mediterranean fever: an overview. Ann Rheum Dis 2003 Oct ; 62 (10) :916–9.
  • 4 Mijatovic V, Hompes PG, Wouters MG. Familial Mediterranean fever and its implications for fertility and pregnancy. Eur J Obstet Gynecol Reprod Biol 2003 Jun ; 10 (108):171–6
  • 5 Tunca M, Akar S, Onen F, Ozdogan H, Kasapcopur O, Yalcinkaya F et al. Familial Mediterranean fever ) in Turkey: results of a nationwide multicenter study. Medicine 2005 Jan; 84 (1):1–11. 
 6 Cobankara V, Fidan G, Turk T, Zencir M, Colakoglu M, Ozen S The prevalence of familial Mediterranean fever in the Turkish province of Denizli: a field study with a zero patient design. Clin Exp Rheumatol 2004 Jul-Aug; 22 (4): 27–30.
  • 7 Michael O, Goldman RD, Koren G. Safety of colchicine therapy during pregnancy. Can Fam Physician 2003 Aug; 49 :967–9.
  • 8 Ben chetrit E, Levy M, Colchicine: 1998 update. Semin Arthritis Rheum 1998 Aug ;28 (1):48–59.
  • 9 Berkenstadt M, Weisz B, Cuckle H, Di-Castro M, Guetta E, Barski G. Chromosomal abnormalities and birth defects among couples with colchicine treated Familial Mediterranean fever. Am J Obstet Gynecol 2005 Oct ;193 (4):1513–6
  • 10 Ditkoff EC,Sauer MV.Successful pregnancy in a Familial Mediterranean fever patient following assisted reproduction. J Assist Reprod Genet 1996 Sep ;13 (8):684– 5.
  • 11 Rabinovitch O, Zemer D, Kukua E, Sohar E, Mashiach S.Colchicine treatment in conception and pregnancy: 231 pregnancies with Familial Mediterranean fever. Am J Repord Immunol 1992 Oct - Dec ; 28 (3–4):245–6.
  • 12 Zemer D, Pras M, Sohar E, Modan M,Cabili S, Gafni J. Colchicine in the prevention and 
treatment of the amyloidosis of familial Mediterranean fever. 
N Engl J Med 1986 Apr ;314 (16):1001–3.
  • 13 Ofir D, Levy A, Wiznitzer A, Mazor M, Sheiner E Familial Mediterranean fever : An independent risk factor for preterm delivery European Journal of Obstetrics & Gynecology and Reproductive Biology 2008 Dec;141 (2) :115–118 14 Yasar 0, Iskender C, Kaymak O, Yaman TS, Uygur D, Danısman N Retrospective evaluation of pregnancy outcomes in women with familial Mediterranean fever J Matern Fetal Neonatal Med 2014 May; 27(7): 733–736 
 15 Ben-Cherit E, Ben-Cherit A, Berkun Y, Ben-Cherit E Pregnancy outcomes in women with familial Mediterranean fever receiving colchicine: is amniocentesis justified? Arthritis Care Res 2010 Feb; 62(2):143–148
  • 16 Ehrenfeld M, Brzezinski A, Levy M, Eliakim M. Fertility and obstetric history in patients with familial Mediterranean fever on long-term colchicine therapy. Br J Obstet Gynaecol 1987 Dec; 94 (12):1186-91.
  • 17 Ben-Chetrit E, Levy M. Colchicine prophylaxis in familial Mediterranean fever: reappraisal after 15 years. Semin Arthritis Rheum 1991 Feb; 20 (4):241-6.
  • 18 Berkenstadt M, Weisz B, Cuckle H, Di-Castro M, Guetta E, Barkai G. Chromosomal abnormalities and birth defects among couples with colchicine treated familial Mediterranean fever. Am J Obstet Gynecol 2005 Oct ;193 (4):1513-6.
  • 19 Venhoff N,Voll RE, Glaser C, Thiel J IL-1-blockade with Anakinra during pregnancy : Retrospective analysis of efficacy and safety in female patients with familial Mediterranean fever Z Rheumatol 2017 Jul ; Epub ahead of print
  • 20 Ilgen U, Küçükşahin O Anakinra use during pregnancy: Report of a case with Familial Mediterranean Fever and infertility. Eur J Rheumatol 2017 Mar ; Epub ahead of print
Toplam 17 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Orjinal Araştırma
Yazarlar

Ebru Alıcı Davutoğlu

Ayşegül Özel 0000-0002-0283-1049

Hakan Erenel Bu kişi benim

Rıza Madazlı Bu kişi benim

Yayımlanma Tarihi 5 Mart 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 49 Sayı: 1

Kaynak Göster

APA Alıcı Davutoğlu, E., Özel, A., Erenel, H., Madazlı, R. (2018). Perinatal Outcomes of 40 Pregnancies with Familial Mediterranean Fever. Zeynep Kamil Tıp Bülteni, 49(1), 77-79. https://doi.org/10.16948/zktipb.333212
AMA Alıcı Davutoğlu E, Özel A, Erenel H, Madazlı R. Perinatal Outcomes of 40 Pregnancies with Familial Mediterranean Fever. Zeynep Kamil Tıp Bülteni. Mart 2018;49(1):77-79. doi:10.16948/zktipb.333212
Chicago Alıcı Davutoğlu, Ebru, Ayşegül Özel, Hakan Erenel, ve Rıza Madazlı. “Perinatal Outcomes of 40 Pregnancies With Familial Mediterranean Fever”. Zeynep Kamil Tıp Bülteni 49, sy. 1 (Mart 2018): 77-79. https://doi.org/10.16948/zktipb.333212.
EndNote Alıcı Davutoğlu E, Özel A, Erenel H, Madazlı R (01 Mart 2018) Perinatal Outcomes of 40 Pregnancies with Familial Mediterranean Fever. Zeynep Kamil Tıp Bülteni 49 1 77–79.
IEEE E. Alıcı Davutoğlu, A. Özel, H. Erenel, ve R. Madazlı, “Perinatal Outcomes of 40 Pregnancies with Familial Mediterranean Fever”, Zeynep Kamil Tıp Bülteni, c. 49, sy. 1, ss. 77–79, 2018, doi: 10.16948/zktipb.333212.
ISNAD Alıcı Davutoğlu, Ebru vd. “Perinatal Outcomes of 40 Pregnancies With Familial Mediterranean Fever”. Zeynep Kamil Tıp Bülteni 49/1 (Mart 2018), 77-79. https://doi.org/10.16948/zktipb.333212.
JAMA Alıcı Davutoğlu E, Özel A, Erenel H, Madazlı R. Perinatal Outcomes of 40 Pregnancies with Familial Mediterranean Fever. Zeynep Kamil Tıp Bülteni. 2018;49:77–79.
MLA Alıcı Davutoğlu, Ebru vd. “Perinatal Outcomes of 40 Pregnancies With Familial Mediterranean Fever”. Zeynep Kamil Tıp Bülteni, c. 49, sy. 1, 2018, ss. 77-79, doi:10.16948/zktipb.333212.
Vancouver Alıcı Davutoğlu E, Özel A, Erenel H, Madazlı R. Perinatal Outcomes of 40 Pregnancies with Familial Mediterranean Fever. Zeynep Kamil Tıp Bülteni. 2018;49(1):77-9.