Mezotelyoma ve akciğer adenokarsinomunun ayırıcı tanısında immünohistokimyasal belirteçlerden calretinin, D2-40, p63 ve tiroid transkripsiyon faktör-1'in rolü

Year 2023, , 125 - 132, 30.08.2023

Mehmet Mustafa Erdoğan , Songül Yerlikaya Kavak

https://doi.org/10.30569/adiyamansaglik.1225533

Abstract

Amaç: Mezotelyoma ile akciğer adenokarsinomunun ayırıcı tanısında morfolojik bulgular yetersizdir. İmmünohistokimyasal inceleme en iyi yardımcı yöntemdir. Çalışmada mezotelyoma ile akciğer adenokarsinomunun ayırıcı tanısında uygun belirteçlerin belirlenmesi amaçlanmıştır.
Gereç ve Yöntem: Bu çalışmada hastanemizde tanı almış akciğer adenokarsinomu ile mezotelyoma olgularına ait patoloji arşivi incelenerek bu olgularda ayırıcı tanıya giderken kullanılan calretinin, D2-40, p63 ve tiroid transkripsiyon faktör-1 (TTF-1) immünhistokimyasal belirteçleri değerlendirilmiştir.
Bulgular: Elde edilen bulgulara göre, 45 mezotelyoma olgusunun 43’ünde D2-40 belirteç pozitifliği, 44’ünde calretinin belirteç pozitifliği, 45 akciğer adenokarsinom olgusunun ise tamamında TTF-1 belirteç pozitifliği bulundu.
Sonuç: Mezotelyoma açısından calretinin ve D2-40 belirteçlerinin, akciğer adenokarsinomu açısından ise TTF-1 immünhistokimyasal belirteçlerinin olgularda yüksek oranda doğru tanı sağladığını tespit ettik.

Keywords

Akciğer adenokarsinom, Mezotelyoma, D2-40, Calretinin, TTF-1

The role of immunohistochemical antibodies calretinin, D2-40, p63 and thyroid transcription factor-1 in the differential diagnosis of mesothelioma and lung adenocarcinoma

Abstract

Aim: Morphological findings are insufficient in the differential diagnosis of mesothelioma and lung adenocarcinoma. Immunohistochemical examination is the best auxiliary method. In this study, it was aimed to determine the appropriate antibodies in the differential diagnosis of mesothelioma and lung adenocarcinoma.
Materials and Methods: In this study, the pathology archive of lung adenocarcinoma and mesothelioma cases diagnosed in our hospital was examined, and the immunohistochemical markers of calretinin, D2-40, p63 and thyroid transcription factor-1 (TTF-1), which were used for differential diagnosis in these cases, were evaluated.
Results: According to the findings obtained, 43 of 45 mesothelioma cases had D2-40 antibody positivity, 44 cases had calretinin antibody positivity, and 45 lung adenocarcinoma cases had antibody positivity. TTF-1 antibody positivity was found in all of them.
Conclusion: We found that calretinin and D2-40 markers for mesothelioma and TTF-1 immunohistochemical markers for lung adenocarcinoma provided a high rate of accurate diagnosis in cases.

Keywords

Lung adenocarcinoma, Mesothelioma, D2-40, Calretinin, TTF-1

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