Diz osteoartritli hastalarda ortalama platelet hacmi ve platelet dağılım genişliği parametrelerinin değerlendirilmesi

Year 2018, Volume: 4 Issue: 2, 750 - 760, 15.08.2018

Onur Kılınç , Ayşe Atılgan Çelik , Semra Coşkun , Adem Yıldırım

https://doi.org/10.30569/adiyamansaglik.377453

Abstract

Amaç:
Bu
çalışmanın amacı, diz osteoartriti tanılı hastalarda ortalama platelet hacmi (OPH)
ve platelet dağılım genişliği (PDG) parametrelerinin değerlendirilmesiydi.

Yöntem:
Çalışmamıza
Ocak 2016 - Aralık 2017 tarihleri arasında Adıyaman Üniversitesi Fiziksel Tıp
Ve Rehabilitasyon polikliniğine başvuran diz osteoartriti tanısı olan 453 hasta
(Gonartroz Grubu) ve bu grupla yaş ve cinsiyet olarak benzer özelliklere sahip
ancak diz osteoartriti tanısı olmayan 341 hasta (Kontrol Grubu) dahil edildi. Hastaların
yaşı, cinsiyeti, platelet sayıları (PS), OPH ve PDG değerleri retrospektif
olarak hastane kayıtları üzerinden elde edilerek kaydedildi. Her iki grup PS, OPH
ve PDG değerleri açısından karşılaştırıldı.

Bulgular:
Gonartroz
grubunda, ortalama OPH düzeyi kontrol grubuna göre anlamlı olarak daha düşük
iken (p=0,001), ortalama PDG değerleri anlamlı olarak daha yüksekti (p=0,003). Ortalama
PS düzeyi Gonartroz grubunda hafif düzeyde daha düşük olmasına rağmen fark
istatistiksel olarak anlamlı değildi (p=0,298).

Sonuç:
Bu
çalışma diz osteoartritli hastalarda OPH ve PDG parametrelerinin diz
osteoartriti tanısı olmayan kişilerden anlamlı olarak farklılık
gösterebileceğini ortaya koymaktadır. Literatürde farklılık olmadığını bildiren
çalışmaların da olması, konuyu tartışmalı kılmaktadır. Daha geniş serilerde,
klinik parametreleri de içeren prospektif çalışmaların fayda sağlayacağı
kanaatindeyiz.

Keywords

diz osteoartriti, ortalama platelet hacmi, platelet dağılım genişliği

Evaluation of mean platelet volume and platelet distribution width parameters in patients with knee osteoarthritis.

Abstract

Aim:  The aim of this study was to evaluate the mean
platelet volume (MPV) and platelet distribution width (PDW) parameters in
patients with knee osteoarthritis.

Material and
Methods: Four hundred fifty-three patients diagnosed with knee
osteoarthritis (Gonarthrosis Group) who admitted to the Physical Medicine and
Rehabilitation outpatient clinic of Adıyaman Education and Research Hospital
between January 2016 and December 2017 and 341 subjects with similar
characteristics as age and gender but without knee osteoarthritis and not
having any disease affecting thrombocyte count and function (Control Group)
were included this study. Patients' age, gender, platelet count (PC), MPV and
PDW values were recorded retrospectively from hospital records. Both groups
were compared in terms of PC, MPV and PDW values.

Results: In the
gonarthrosis group, mean MPV levels (7,84 ± 1,58 fL) were significantly lower
than the control group (8,23 ± 1,69 fL; p = 0.001) and mean PDW values were
significantly higher (18,67 ± 1,81 fL and 18,12 ± 3,31 fL, respectively; p =
0.003). Although the mean PC level was slightly lower in the gonarthrosis
group, the difference was not statistically significant (p = 0.298).

Conclusion: This study
suggests that MPV and PDW parameters in patients with knee osteoarthritis may
differ significantly from those without knee osteoarthritis.  The fact that there are studies in the
literature that there is no difference makes this issue controversial. We
believe that prospective studies in larger series and including clinical
parameters would be useful.

Keywords

knee osteoarthritis, mean platelet volume, platelet distribution width

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