Vernal Keratokonjonktivit Hastalarında Kırmızı Hücre Dağılım Genişliğinin Değerlendirilmesi

Year 2019, Volume: 5 Issue: 2, 1547 - 1553, 15.08.2019

Şemsettin Bilak , Burak Bilgin

https://doi.org/10.30569/adiyamansaglik.581417

Abstract

Amaç:
Vernal Keratokonjonktivit (VKK) oküler yüzeyin bilateral, kronik, alerjik enflamatuar
bir hastalığıdır. Kırmızı hücre dağılım genişliği (RDW) birçok kronik enflamatuar
durumda artış gösteren hematolojik bir laboratuvar testidir. Çalışmamızın amacı
RDW’nin VKK gelişimi ile olan ilişkisini araştırmaktır.

Yöntem:
Klinik
olarak VKK tanısı konmuş 72 hasta ile aynı yaş ortalaması ve cinsiyete sahip 72
sağlıklı birey çalışmaya dahil edildi. Hastalardan alınan venöz kan ile tam kan
sayımı yapılarak, RDW değeri elde edildi. Elde edilen RDW değerleri istatistiksel
olarak karşılaştırıldı.

Bulgular:
VKK
gurubu 41 erkek, 31 kadın hastadan oluşurken, kontrol gurubu 39 erkek, 33 kadın
hastadan oluşmaktaydı. VKK gurubunun yaş
ortalaması 13.06±0.65 yıl, kontrol gurubunun yaş ortalaması ise 12.36± 0.51
yıldı. Gruplar arasında cinsiyet ve yaş açısından anlamlı bir fark izlenmedi
(p>0.05). RDW değeri VKK grubunda % 12.8±1.45, kontrol gurubunda ise %
11.63±0.87 idi (p=0.01).

Sonuç: RDW
artışı, VKK ile anlamlı bir şekilde ilişkilidir. RDW artışı VKK’te kronik inflamasyon ve artmış oksidatif stresin patogenezde
önemli rol oynadığını düşündürmektedir. 

Keywords

Vernal keratokonjonktivit, Kırmızı hücre dağılım aralığı

Evaluation of Red Cell Distribution Width in Vernal Keratoconjunctivitis Patients

Abstract

Purpose: Vernal
Keratoconjunctivitis (VKK) is a bilateral, chronic, allergic inflammatory
disease of the ocular surface. Red cell distribution width (RDW) is a
hematological laboratory test that has been shown to increase in many chronic
inflammatory conditions. The aim of this study is to investigate the
relationship between RDW and VKK development.

Materials and Methods: Clinically diagnosed of 72 patients with VKK, and 72 age and sex matched
healthy individuals were enrolled to the study. 
Venous bloods were obtained from the all participants. Complete blood
count test was performed and RDW values were obtained. The obtained RDW values
were compared between groups statistically.

Results: The VKK group consisted
of 41 male and 31 female patients, while the control group consisted of 39 male
and 33 female patients. The mean age of VKK group was 13.06 ± 0.65 years and
the mean age of the control group was 12.36 ± 0.51 years. There was no
significant difference between the groups in terms of gender and age (p> 0.05).
RDW value was 12.8 ± 1.45 % in VKK group and 11.63 ± 0.87 % in the control
group (p = 0.01).

Conclusion: RDW increase was
significantly associated with VKK. The increase in RDW suggests that chronic
inflammation and increased oxidative stress play an important role in the
pathogenesis of VKK.

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