Yüksek dozda parasetamolün dişi sıçanların tiroid bezi üzerine olumsuz etkileri

Year 2020, Volume: 6 Issue: 3, 311 - 319, 03.12.2020

Banu Eren , Sare Ulubay , Dilek Sağır , Burcu Demirel Yılmaz , Sevcan Mercan

https://doi.org/10.30569/adiyamansaglik.753398

Abstract

Amaç: Bu çalışmanın amacı, etki mekanizması henüz tam olarak bilinmeyen ancak bilinçsizce kullanılan bir analjezik olan parasetamolün tiroid bezi üzerinde toksisiteye neden olup olmadığını belirlemektir.
Gereç ve Yöntem: Toplam 25 adet dişi Wistar albino rat kontrol (K), Parasetamol 7 gün (P7), parasetamol 14 gün (P14), Parasetamol 21 gün (P21) ve parasetamol 28 gün (P28) olarak 5 gruba ayrıldı. Parasetamol gruplarındaki sıçanlara sakrifiye edilecekleri güne kadar gavaj ile 750 mg/kg/gün parasetamol verildi. Çıkarılan tiroid bezlerine rutin histolojik prosedürler uygulandı. Tiroid dokusu kesitleri morfometrik ve histopatolojik olarak değerlendirildi.
Bulgular: Parasetamol verilen grupların tiroid dokusu kesitlerinde folikül epitel hücrelerinde sitoplazmik vakuolizasyon, folikül ve kolloid yapılarında bozulma saptandı. P7 grubuna ait folikül çap ölçümü ortalaması kontrol grubuna kıyasla anlamlı azaldı (p<0,05). Tüm parasetamol gruplarında folikül epitel yüksekliği ortalaması kontrol grubuna kıyasla anlamlı olarak arttı (p<0.05).
Sonuç: Bu sonuçlar, yüksek dozda parasetamolün kullanım süresine bağlı olarak tiroid bezi üzerinde toksik etkilere neden olduğunu göstermektedir.

Keywords

Parasetamol (asetaminofen), Tiroid, Histopatoloji

Supporting Institution

Ondokuz Mayıs Üniversitesi

Project Number

PYO.FEN.1904.15.001

Thanks

Ondokuz Mayıs Üniversitesi Proje Yönetim Ofisi Koordinatörlüğü’ne destekleri için teşekkür ederiz.

Adverse effects of high-dose paracetamol on thyroid gland of female rats

Abstract

Aim: The aim of this study is to determine whether paracetamol, an analgesic whose mechanism of action is not yet fully known but used unconsciously, causes toxicity on the thyroid gland.
Materials and Methods: A total of 25 female Wistar albino rats divided into five groups as Control (C), Paracetamol 7 days (P7), Paracetamol 14 days (P14), Paracetamol 21 days (P21) and Paracetamol 28 days (P28). The Paracetamol groups were given 750 mg/kg/day paracetamol via oral gavage administration until the day they were sacrificed. Routine histological procedures were applied to the removed thyroid glands. Thyroid tissue sections were evaluated morphometrically and histopathologically.
Results: Cytoplasmic vacuolization and deterioration in follicle and colloid structures were detected in follicular epithelial cells in thyroid tissue sections of groups given paracetamol. The mean of follicle diameter measurement of the P7 group was significantly decreased compared to the control group (p<0.05). In all paracetamol groups, the mean follicular epithelium height increased significantly compared to the control group (p<0.05).
Conclusion: These results show that high doses of paracetamol cause toxic effects on the thyroid gland depending on the duration of use.

Keywords

Paracetamol (acetaminophen), Thyroid, Histopathology

Project Number

PYO.FEN.1904.15.001

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