Metamfetamin kullanım bozukluğunda beyin hacmi ölçümlerinin volbrain yöntemi kullanılarak sağlıklı bireylerle karşılaştırılması

Year 2023, Volume: 9 Issue: 3, 188 - 198, 31.12.2023

Gülnihal Deniz , Nurgül Karakurt , Halil Özcan , Niyazi Acer

https://doi.org/10.30569/adiyamansaglik.1355955

Cited By: 2

Abstract

Amaç: Bu çalışmanın amacı, metamfetamin kullanım bozukluğu (MKB) olan bireylerde beyin yapılarını incelemek ve metamfetaminin bu yapılar üzerindeki olası etkilerini anlamaktır.
Gereç ve Yöntem: Çalışmada 21 MKB ve 21 sağlıklı kontrol retrospektif olarak değerlendirildi. VolBrain segmentasyon yöntemi kullanıldı.
Bulgular: Substantia grisea (SG), kortikal SG serebrum total ve SG hacimleri sağlıklı kontrol grubuna kıyasla daha az ve anlamlı bulunmuştur (p<0,01). Accumbens, pars basalis telencephali, lobus caudatus, globus pallidus, putamen ve lobus parietalis hacimleri MKB’de artmıştır (p<0,01). Amygdala, hippocampus, ventral diensefalon, lobus frontalis, gyrus orbitalis posterior, gyrus precentralis, lobus temporalis, calcarine cortex, gyrus occipitalis medium, gyrus occipitalis superior, lobus limbicus hacimleri MKB’de sağlıklı kontrollere kıyasla anlamlı derecede küçüktü.
Sonuç: Bu çalışma, MKB’nin beyin yapıları üzerindeki etkilerini daha iyi anlamamıza yardımcı oldu. Ayrıca, MKB tedavisi ve önlenmesi için etkili stratejiler geliştirmek için önemli bilgiler sağlamıştır.

Keywords

Metamfetamin;, Beyin, Gri madde, Bazal ön beyin

Ethical Statement

Ataturk University Faculty of Medicine Clinical Research Ethics Committee with the ethics committee decision numbered B.30.2.ATA.0.01.00/128 and dated 26.01.2023. This study conformed to the Helsinki Declaration.

Supporting Institution

There is no person/organization that financially supports this study.

Comparison of brain volume measurements in methamphetamine use disorder with healthy individuals using volbrain method

Abstract

Aim: This study aims to examine brain structures in individuals with methamphetamine use disorder (MUD) and to understand the possible effects of methamphetamine on these structures.
Materials and Methods: The study was retrospectively evaluated in 21 MUD and 21 healthy controls. VolBrain segmentation method was used.
Results: Grey Matter (GM), Cortical GM, Cerebrum total, and GM volumes were found to be less and significantly higher in MUD compared to healthy controls (p<0.01). Accumbens, Basal Forebrain, Caudate, Pallidum, Putamen, and Parietal Lobe volumes were increased in MUD (p<0.01). Amygdala, Hippocampus, Ventral Diencephalone, Frontal Lobe, Posterior Orbital Gyrus, Precentral Gyrus, Temporal Lobe, Calcarine Cortex, Middle Occipital Gyrus, Superior Occipital Gyrus, Limbic Cortex volumes were significantly smaller in MUD compared to healthy controls.
Conclusion: This study helped us better understand MUD's effects on brain structures. It also provided important information for developing effective strategies for treating and preventing MUD.

Keywords

Methamphetamine, Brain, Grey matter, Basal forebrain

Ethical Statement

Ataturk University Faculty of Medicine Clinical Research Ethics Committee with the ethics committee decision numbered B.30.2.ATA.0.01.00/128 and dated 26.01.2023. This study conformed to the Helsinki Declaration.

Supporting Institution

There is no person/organization that financially supports this study.

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