Laktoperoksidaz enzimini inhibe eden maddelerin belirlenmesi için yapılan bazı çalışmaların incelenmesi ve enzimin uygulama alanlarının örneklendirilmesi

Year 2019, Volume: 2 Issue: 2, 1 - 8, 31.12.2019

Gözde Baydemir Peşint , Ece Kaya , Hatice İmge Oktay Başeğmez

Abstract

Lactoperoxidase (LPO; E.C.
1.11.1.7) was isolated from milk in 1940s by Theorell et al., and in the
following years, it was purified by Morrison et al. using ion-exchange
chromatography. This enzyme is a glycoprotein that is a member of the
peroxidase family and contains the heme group as a prosthetic group.
Lactoperoxidase is an oxidoreductase enzyme that exhibits antimicrobial action against pathogens
secreted from the digestive tract of newborns. This enzyme is found in saliva
and tears as well as in milk.

The determination of
lactoperoxidase inhibitors and how the enzyme will be affected in case of
antibiotic use is very important for newborn health. The studies reviewed here
contain references for the determination of the inhibitors of lactoperoxidase
and the degree of inhibition of these inhibitors, and the use of antibiotics in
newborns. At the same time, it is very important to know the substances that
increase the activity of the enzyme, especially for use in the food and
pharmaceutical industries.

Keywords

Enzim, Laktoperoksidaz, Saflaştırma

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