The evaluation of sleep quality, anxiety disorder and depression in older adults with Parkinson disease

Year 2021, Volume: 4 Issue: 2, 147 - 153, 28.03.2021

Gulay Ilkhan , Hakan Celikhisar , Aslı Kılavuz

https://doi.org/10.32322/jhsm.848699

Abstract

Amaç: Bu çalışmanın amacı, Parkinson hastalığı olan yaşlı yetişkinlerde uyku bozukluğu, anksiyete ve depresyon sıklığı yanı sıra bu şikayetler ile hastalığın evresi ve süresi arasındaki ilişkiyi incelemektir.
Gereç ve Yöntem: Parkinson hastalığı tanısı ile takip edilen toplam 585 yaşlı yetişkine Epworth Uykululuk Ölçeği, Pittsburgh Uyku Kalitesi İndeksi, Uykusuzluk Şiddet İndeksi, Beck Depresyon Envanteri ve Hamilton Anksiyete Ölçeği uygulandı. Elde edilen veriler 585 sağlıklı bireyden oluşan kontrol grubunun verileri ile karşılaştırılarak yorumlanmıştır.
Bulgular: Pittsburgh Uyku Kalitesi İndeksine göre hasta grubunda gündüz işlevleri ve subjektif uyku kalitesi istatistiksel olarak anlamlı düzeyde daha kötü bulunmuştur. Beck Depresyon Envanteri puanı ile Birleşik Parkinson Hastalığı Derecelendirme Ölçeği ve Hoehn Yahr Ölçeği arasında pozitif ve istatistiksel olarak anlamlı bir ilişki belirlenmiştir. Hastalığın evresi arttıkça depresyon sıklığı artarken, hastalık süresi arttıkça anksiyete sıklığı da artmaktadır.
Sonuç: Özellikle Parkinson hastalığı olan, klinik olarak daha ağır olan ve daha uzun süredir tedavi gören yaşlı yetişkinlerde depresyon ve anksiyete varlığı sorgulanmalıdır. Tedaviye bağlı komplikasyonları olan hastalar uyku bozuklukları açısından değerlendirilmelidir. Parkinson hastalığının sadece motor semptomlarla ilişkili olmadığı, motor dışı semptomların etkili bir şekilde tedavi edilmesinin hastaların yaşam kalitelerini de artıracağı unutulmamalıdır.

Keywords

anksiyete, depresyon, yaşlı, Parkinson hastalığı, uyku bozukluğu

Supporting Institution

Destekleyen kurum yoktur.

Project Number

Yoktur.

Thanks

We would like to thank Fikri Ak Neurology specialist.

References

• Kalia LV, Lang AE. Parkinson's disease. Lancet 2015; 386: 896‐912.
• Yazar T, Olgun Yazar H. Evaluation of C-reactive protein/albumin ratio according to stage in patients with idiopathic Parkinson disease. Turk J Neurol 2019; 25: 123-8.
• Defebvre L, Krystkowiak P. Movement disorders and stroke. Rev Neurol (Paris) 2016; 172: 483‐7.
• Leentjens AF. Depression in Parkinson's disease: conceptual issues and clinical challenges. J Geriatr Psychiatry Neurol 2004; 17: 120‐6.
• Reijnders JS, Ehrt U, Weber WE, Aarsland D, Leentjens AF. A systematic review of prevalence studies of depression in Parkinson's disease. Mov Disord 2008; 23: 183‐313.
• Siciliano M, Trojano L, Santangelo G, De Micco R, Tedeschi G, Tessitore A. Fatigue in Parkinson's disease: a systematic review and meta-analysis. Mov Disord 2018; 33: 1712‐23.
• Samudra N, Patel N, Womack KB, Khemani P, Chitnis S. Psychosis in Parkinson disease: a review of etiology, phenomenology, and management. Drugs Aging 2016; 33: 855‐63.
• Egan SJ, Laidlaw K, Starkstein S. Cognitive behaviour therapy for depression and anxiety in Parkinson's disease. J Parkinsons Dis 2015; 5: 443‐51.
• Goodarzi Z, Mele B, Guo S, et al. Guidelines for dementia or Parkinson's disease with depression or anxiety: a systematic review. BMC Neurol 2016; 16: 244.
• Seppi K, Weintraub D, Coelho M, et al. The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor symptoms of Parkinson's disease. Mov Disord 2011; 26: S42‐S80.
• Stanković I, Petrović I, Pekmezović T, et al. Longitudinal assessment of autonomic dysfunction in early Parkinson's disease. Parkinsonism Relat Disord 2019; 66: 74‐9.
• Seppi K, Ray Chaudhuri K, Coelho M, et al. Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review. Mov Disord 2019; 34: 180‐98.
• Forsaa EB, Larsen JP, Wentzel-Larsen T, et al. A 12-year population-based study of psychosis in Parkinson disease. Arch Neurol 2010; 67: 996‐1001.
• Deng X, Tang CY, Zhang J, et al. The cortical thickness correlates of clinical manifestations in the mid-stage sporadic Parkinson's disease. Neurosci Lett 2016; 633: 279‐89.
• Kim J, Jang S, Choe HK, Chung S, Son GH, Kim K. Implications of circadian rhythm in dopamine and mood regulation. Mol Cells 2017; 40: 450‐6.
• Tysnes OB, Storstein A. Epidemiology of Parkinson's disease. J Neural Transm (Vienna) 2017; 124: 901‐5.
• Li F, Takechi H, Saito R, et al. A comparative study: visual rating scores and the voxel-based specific regional analysis system for Alzheimer's disease on magnetic resonance imaging among subjects with Alzheimer's disease, mild cognitive impairment, and normal cognition. Psychogeriatrics 2019; 19: 95‐104.
• Akbostancı MC, Balaban H, Atbaşoğlu C. Birleşik Parkinson Hastalığı Değerleme Ölçeği Motor Muayene Bölümü ve Anormal İstemsiz Hareketler Ölçeği’nin değerlendiriciler arası güvenilirlik çalışması. (Interrater reliability of the Turkish version of the Motor Examination Section of Unified Parkinson’s Disease rating scale and Abnormal Involuntary Movements scale). Parkinson Hastalığı ve Hareket Bozuklukları Derg 2000; 3: 7-13.
• Lopez FV, Split M, Filoteo JV, et al. Does the Geriatric Depression scale measure depression in Parkinson's disease? Int J Geriatr Psychiatry 2018; 33: 1662‐70.
• McPherson A, Martin CR. A narrative review of the Beck depression inventory (BDI) and implications for its use in an alcohol-dependent population. J Psychiatr Ment Health Nurs 2010; 17: 19‐30
• Corsetti MT, Rossi E, Bonvino S, Randazzo P. Psychological distress and quality of life are improved in autoimmune patients through Tandem-Psychotherapy, combining individual hypnosis and eye movement desensitization and reprocessing (EMDR) treatment for trauma, followed by supportive-expressive group therapy. Clin Rheumatol 2020; 39: 1331‐9. doi:10.1007/s10067-019-04862-1.
• Demirci K, Akgönül M, Akpinar A. Relationship of smartphone use severity with sleep quality, depression, and anxiety in university students. J Behav Addict 2015; 4: 85‐92.
• Scholtens LH, van den Heuvel MP. Multimodal connectomics in psychiatry: bridging scales from micro to macro. Biol Psychiatry Cogn Neurosci Neuroimaging 2018; 3: 767‐76.
• Babel P. The Influence of State and Trait anxiety on the Memory of Pain. Pain Med 2017; 18: 2340‐9.
• Leentjens AF, Dujardin K, Marsh L, Richard IH, Starkstein SE, Martinez-Martin P. anxiety rating scales in Parkinson's disease: a validation study of the Hamilton anxiety rating scale, the Beck anxiety inventory, and the hospital anxiety and depression scale. Mov Disord 2011; 26: 407‐15.
• McCarty DE, Reddy A, Keigley Q, Kim PY, Marino AA. Vitamin D, race, and excessive daytime sleepiness. J Clin Sleep Med 2012; 8: 693‐7.
• Spira AP, Beaudreau SA, Stone KL, et al. Reliability and Validity of the Pittsburgh sleep quality index and the Epworth sleepiness scale in Older Men. J Gerontol A Biol Sci Med Sci 2012; 67: 433-9.
• Raniti MB, Waloszek JM, Schwartz O, Allen NB, Trinder J. Factor structure and psychometric properties of the Pittsburgh Sleep Quality Index in community-based adolescents. Sleep 2018; 41.
• Mollayeva T, Thurairajah P, Burton K, Mollayeva S, Shapiro CM, Colantonio A. The Pittsburgh sleep quality index as a screening tool for sleep dysfunction in clinical and non-clinical samples: A systematic review and meta-analysis. Sleep Med Rev 2016; 25: 52‐73.
• Castronovo V, Galbiati A, Marelli S, et al. Validation study of the Italian version of the Insomnia severity index (ISI). Neurol Sci 2016; 37: 1517‐24.
• Boysan M, Güleç M, Beşiroğlu L, et al. Psychometric properties of the Insomnia severity index in Turkish sample. Anadolu Psikiyatri Derg 2010; 11: 248-52.
• Ratti PL, Nègre-Pagès L, Pérez-Lloret S, et al. Subjective sleep dysfunction and insomnia symptoms in Parkinson's disease: Insights from a cross-sectional evaluation of the French CoPark cohort. Parkinsonism Relat Disord 2015; 21: 1323‐9.
• Shen Y, Huang JY, Li J, Liu CF. Excessive daytime sleepiness in Parkinson's disease: clinical implications and management. Chin Med J (Engl) 2018; 131: 974‐81.
• Sveinbjornsdottir S. The clinical symptoms of Parkinson's disease. J Neurochem 2016; 139 Suppl 1: 318‐24.
• Mahale R, Yadav R, Pal PK. Rapid eye movement sleep behavior disorder in young- and older-onset Parkinson disease: a questionnaire-based study. Sleep Med 2014; 15: 642‐6.
• Bargiotas P, Lachenmayer ML, Schreier DR, Mathis J, Bassetti CL. Sleepiness and sleepiness perception in patients with Parkinson's disease: a clinical and electrophysiological study. Sleep 2019; 42: zsz004.
• Sobreira-Neto MA, Pena-Pereira MA, Sobreira EST, et al. Chronic insomnia in patients with Parkinson disease: which associated factors are relevant? J Geriatr Psychiatry Neurol 2020; 33: 22‐7.
• Bargiotas P, Schuepbach MWM, Bassetti CL. Sleep-wake disturbances in the premotor and early stage of Parkinson's disease. Curr Opin Neurol 2016; 29: 763-72.