Single-center experience of childhood Hodgkin lymphoma treated without radiotherapy

Year 2021, Volume: 4 Issue: 6, 853 - 857, 24.09.2021

Ebru Yılmaz , Memnune Arslan , Şefika Akyol Alper Özcan , Gökmen Zararsız Ümmühan Abdulrezzak , Olgun Kontaş , Özlem Canöz , Ekrem Ünal , Musa Karakükçü

https://doi.org/10.32322/jhsm.984394

Abstract

Aim: Hodgkin lymphoma (HL) constitutes 40% of childhood lymphomas and approximately 6% of all childhood cancers. It is tried to achieve cure with combined treatment modalities consisting of chemotherapy, radiotherapy, monoclonal antibodies, and new treatment agents such as nivolumab. Radiotherapy-related infertility, secondary cancer, thyroid dysfunction, cardiovascular diseases, pulmonary fibrosis, and local skin reactions can be seen in the pediatric age group with a long life expectancy. In this article, pediatric patients diagnosed with Hodgkin lymphoma without the use of radiotherapy in the treatment were evaluated retrospectively and the survival results were reported as a single-center experience.
Material and Method: The patients with Hodgkin Lymphoma in the Pediatrics Hematology-Oncology Center at Erciyes University between January 2010 and December 2019 were included in the study and the data of the patients were evaluated retrospectively.
Results: In 68 pediatric patients with a mean age of 10.7 (±4.6) years, the male/female ratio was 1.3. The most detected finding at the time of diagnosis was cervical lymphadenopathy (83.8%). The most common mixed cellular subtype was identified (48.5%). Stage I-II disease was observed in 38.3% of the patients, and stage III-IV disease was observed in 61.7% of the patients. The median follow-up period of the patients was 61 (range, 8.3-161.6) months. Disease-free survival and overall survival were 85.3% and 94.1%, respectively. Treatment modalities to be used in this disease group, which has a high chance of cure after cytotoxic treatment, should be selected considering treatment-related long-term complications.
Conclusion: Acceptable good results obtained without radiotherapy are satisfactory and the chance of curative success will increase with the addition of new target agents to the treatment.

Keywords

Hodgkin lymphoma, children, radiotherapy

Supporting Institution

Yok

Project Number

Yok

Thanks

The authors thank Prof. Dr. Mehmet Akif ÖZDEMİR, Prof. Dr. Türkan PATIROĞLU for their valuable contributions to the study.

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