Can hematologic parameters predict isolated oligohydramnios and isolated polyhydramnios?

Year 2023, Volume: 6 Issue: 5, 1064 - 1068, 28.09.2023

Mustafa Bertan Demir , Şadan Tutuş , Cevat Rifat Cündübey

https://doi.org/10.32322/jhsm.1335130

Abstract

Aims: We fulfilled this study to anticipate the diagnosis of isolated oligohydramnios (IO) and isolated polyhydramnios (IP) by using the first trimester value of hematologic parameters.
Methods: We conducted a retrospective research 32 and 42 weeks of gestation women with IO and IP between in a single tertiary center in Turkey. In this cohort research three groups are composed of 65 IO patients and 56 IP patients and normal 97 patients that had normal volume of amniotic fluid.
Results: While PLR were significantly increased in the IO pregnants (p <0.05) the distinction was not displayed in the IP pregnants. In addition, there was no notable variation in hematologic parameters; in terms of NLR, WBC, Hgb, MCV, PLT, PDW between patients and control patients (p >0.05).
Conslusion: PLR values were independently associated with isolated oligohydramnios but not to isolated polyhydramnios. Hematologic parameters can be helpful in predicting isolated oligohydramnios.

Keywords

First trimester, NLR, PLR, isolated oligohydramnios, isolated polyhydramnios

References

• Shrem G, Nagawkar SS, Hallak M, Walfisch A. Isolated Oligohydramnios at Term as an Indication for Labor Induction: A Systematic Review and Meta-Analysis. Fetal Diagn Ther. 2016;40(3):161-173. doi:10.1159/000445948
• Hill LM, Breckle R, Wolfgram KR, O'Brien PC. Oligohydramnios: ultrasonically detected incidence and subsequent fetal outcome. Am J Obstet Gynecol. 1983;147(4):407-410. doi:10.1016/s0002-9378(16)32235-9
• ACOG committee opinion no. 560: Medically indicated late-preterm and early-term deliveries. Obstet Gynecol. 2013;121(4):908-910. doi:10.1097/01.AOG.0000428648.75548.00
• Rabie N, Magann E, Steelman S, Ounpraseuth S Oligohydramnios in complicated and uncomplicated pregnancy: a systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2017;49(4):442.
• Chamberlain PF, Manning FA, Morrison I, Harman CR, Lange IR. Ultrasound evaluation of amniotic fluid volume. I. The relationship of marginal and decreased amniotic fluid volumes to perinatal outcome. Am J Obstet Gynecol. 1984;150(3):245-249. doi:10.1016/s0002-9378(84)90359-4
• Ashwal E, Hiersch L, Melamed N, Aviram A, Wiznitzer A, Yogev Y. The association between isolated oligohydramnios at term and pregnancy outcome. Arch Gynecol Obstet. 2014;290(5):875–881.
• Golan A, Wolman I, Sagi J, Yovel I, David MP. Persistence of polyhydramnios during pregnancy--its significance and correlation with maternal and fetal complications. Gynecol Obstet Invest. 1994;37(1):18-20. doi:10.1159/000292513
• Dashe JS, McIntire DD, Ramus RM, Santos-Ramos R, Twickler DM. Hydramnios: anomaly prevalence and sonographic detection. Obstet Gynecol. 2002;100(1):134-139. doi:10.1016/s0029-7844(02)02013-6
• Ben-Chetrit A, Hochner-Celnikier D, Ron M, Yagel S. Hydramnios in the third trimester of pregnancy: a change in the distribution of accompanying fetal anomalies as a result of early ultrasonographic prenatal diagnosis. Am J Obstet Gynecol. 1990;162(5):1344
• Stoll CG, Alembik Y, Dott B. Study of 156 cases of polyhydramnios and congenital malformations in a series of 118,265 consecutive births. Am J Obstet Gynecol. 1991;165(3):586-590. doi:10.1016/0002-9378(91)90290-8
• Hughes DS, Magann EF, Whittington JR, Wendel MP, Sandlin AT, Ounpraseuth ST. Accuracy of the ultrasound estimate of the amniotic fluid volume (amniotic fluid ındex and single deepest pocket) to ıdentify actual low, normal, and high amniotic fluid volumes as determined by quantile regression. J Ultrasound Med. 2020;39(2):373.
• Serin S, Avci F, Ercan O, Kostu B, Bakacak M, Kiran H. Is neutrophil/lymphocyte ratio a useful marker to predict the severity of pre-eclampsia? Pregnancy Hypertension. 2016;6(1):22-25.
• Miremberg H, Grinstein E, Herman HG, et al. The association between isolated oligohydramnios at term and placental pathology in correlation with pregnancy outcomes. Placenta. 2020;90:37-41. doi:10.1016/j.placenta.2019.12.004
• Feng JF, Huang Y, Chen QX. Preoperative platelet lymphocyte ratio (PLR) is superior to neutrophil lymphocyte ratio (NLR) as a predictive factor in patients with esophageal squamous cell carcinoma. World J Surg Oncol. 2014;12:58. doi:10.1186/1477-7819-12-58
• Turgut A, Sak ME, Ozler A, Soydinc HE, Karacor T, Gül T. Alterations of peripheral blood cells in tubal ectopic pregnancy. Ginekol Pol. 2013;84(3):193-196.
• Mellembakken JR, Aukrust P, Hestdal K, Ueland T, Abyholm T, Videm V. Chemokines and leukocyte activation in the fetal circulation during preeclampsia. Hypertension. 2001;38(3):394-398. doi:10.1161/01.hyp.38.3.394
• Erten O, Tekeli Taskomur A. Relationship of cystatin C, Hs-CRP, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio with isolated oligohydramnios. Ginekol Pol. 2022;93(11):881-888. doi:10.5603/GP.a2021.0230
• Sonaglioni A, Esposito V, Caruso C, et al. Association between neutrophil to lymphocyte ratio and carotid artery wall thickness in healthy pregnant women. Eur J Obstet Gynecol Reprod Biol. 2020;255:98-104. doi:10.1016/j.ejogrb.2020.10.034
• Mantovani A, Cassatella MA, Costantini C, Jaillon S. Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol. 2011;11(8):519-531. doi:10.1038/nri3024
• Hershko Klement A, Hadi E, Asali A, et al. Neutrophils to lymphocytes ratio and platelets to lymphocytes ratio in pregnancy: A population study. PLoS One. 2018;13(5).e0196706
• Challis JR, Lockwood CJ, Myatt L, Norman JE, Strauss JF 3rd, Petraglia F. Inflammation and pregnancy. Reprod Sci. 2009;16(2):206-215. doi:10.1177/1933719108329095
• Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation?. Curr Pharm Des. 2011;17(1):47-58. doi:10.2174/138161211795049804
• Miremberg H, Grinstein E, Herman HG, et al. The association between isolated oligohydramnios at term and placental pathology in correlation with pregnancy outcomes. Placenta. 2020;90:37-41. doi:10.1016/j.placenta.2019.12.004
• Siristatidis C, Christoforaki V, Zafeiriou Z, Mastorakos G, Vrantza T, Daskalakis G. First trimester neutrophil-to-lymphocyte ratio (NLR) and pregnancy outcomes in medically assisted reproduction (MAR): a case control study. Gynecol Endocrinol. 2019;35(5):434-438. doi:10.1080/09513590.2018.1534949
• Kurt RK, Aras Z, Silfeler DB, Kunt C, Islimye M, Kosar O. Relationship of red cell distribution width with the presence and severity of preeclampsia. Clin Appl Thromb Hemost. 2015;21(2):128-131. doi:10.1177/1076029613490827
• Dorleijn DM, Cohen-Overbeek TE, Groenendaal F, Bruinse HW, Stoutenbeek P. Idiopathic polyhydramnios and postnatal findings. J Matern Fetal Neonatal Med. 2009;22(4):315-320. doi:10.1080/14767050802531870
• Touboul C, Picone O, Levaillant JM, et al. Clinical application of fetal urine production rate in unexplained polyhydramnios. Ultrasound Obstet Gynecol. 2009;34(5):521-525. doi:10.1002/uog.6440
• Ross MG, Brace RA; National Institute of Child Health and Development Workshop Participants. National Institute of Child Health and Development Conference summary: amniotic fluid biology--basic and clinical aspects. J Matern Fetal Med. 2001;10(1):2-19. doi:10.1080/714904292