Yoğun Bakım Hastasında Hepatit C Virüsünün Peg-İnterferon ve Ribavirin ile Tedavisi Atriyoventriküler Nodal Reenteran Taşikardiye Neden Olabilir

Year 2016, Volume: 19 Issue: 2, 120 - 122, 01.08.2016

Mustafa Yıldız , Ahmet Çağrı Aykan Banu Şahin Yıldız Gönenç Kocabay

Abstract

Hepatit C
virüsü (HCV) tedavisinde peginterferon (Peg-IFN)2b ve ribavirin tedavisi konvansiyonel interferon ve
ribavirin tedavisinden daha etkilidir. Peg-IFN ve ribavirin tedavisinin önemli
etkilerinin yanında ateş, halsizlik, heyecan, huzursuzluk, nötropeni ve trombositopeni
gibi bir çok yan etki görülebilir. Ayrıca kardiyak aritmiler ve senkop gibi
nadir olaylar da Peg-IFN
tedavisine bağlı gelişebilir. Bizler bu çalışmada Peg-IFN ve ribavirin tedavisi sırasında presenkop atağı ve
reenteran taşikardilerin en sık formu olan atriyoventriküler nodal reenteran
taşikardi gelişen bir yoğun bakım hastasını sunuyoruz.

Keywords

Hepatit C virüsü, Peg-interferon, ribavirin, atriyoventriküler nodal reenteran taşikardi

Treatment of Hepatitis C Virus with Peginterferon and Ribavirin May Trigger Atrioventricular Nodal Reentrant Tachycardia in An Intensive Care Unit Patient

Abstract

The
treatment of hepatitis C virus (HCV) with peginterferon (Peg-IFN) α2b and
ribavirin is more effective than with conventional interferon and ribavirin.
Despite the important effects of Peg-IFN and ribavirin therapy, many side
effects, such as fever, fatigue, anxiety, irritability, neutropenia and
thrombocytopenia, may be observed. In addition, cardiac arrhythmias and syncope
are rare consequences of Peg-IFN therapy. In this study, we report an intensive
care unit patient who developed atrioventricular nodal reentrant tachycardia
(AVNRT), which is the most common type of reentrant supraventricular
tachycardia, and presyncopal attack during Peg-IFN and ribavirin therapy.

Keywords

Hepatitis C virus, peginterferon, ribavirin, atrioventricular nodal reentrant tachycardia

References

• 1. Wilkins T, Malcolm JK, Raina D, Schade RR. Hepatitis C: diagnosis and treatment. Am Fam Physician 2010;81:1351-7.
• 2. Okanoue T, Sakamoto S, Itoh Y, Minami M, Yasui K, Sakamoto M, et al. Side effects of high-dose interferon therapy for chronic hepatitis C. J Hepatol 1996;25:283-91.
• 3. El-Atrebi K, El-Bassyouni HT. Management of rare side effects of peginterferon and ribavirin therapy during hepatitis C treatment: a case report. Cases J 2009;2:7429.
• 4. Katritsis DG, Camm AJ. Atrioventricular nodal reentrant tachycardia. Circulation 2010;122:831-40.
• 5. Yildiz M, Aykan AC, Kahveci G, Demir S, Ozkan M. Transvenous radiofrequency ablation theraphy as an effective and safe method for the treatment of the slow pathway of atrioventricular nodal re-entrant tachycardia. Koşuyolu Heart J 2011;14:51-5.