Numb Chin Syndrome: A Sign of Lung Adenocarcinoma
Year 2021,
Volume: 12 Issue: 1, 120 - 123, 30.04.2021
Hüseyin Gülcan
,
Uğur Gülşen
Abstract
Objective: Numb chin syndrome (NCS), which is a sensory neuropathy and also known as mental neuropathy, is characterized by paresthesia or decreased sensation in lower lip, gingiva and oral mucosa. This condition is regarded as worrisome because it may be associated with malignancies.
Case: A 34-year-old female patient referred to the clinic with complaint of paresthesia in right lower lip. A lytic lesion involving the inferior alveolar nerve was detected on radiographic examination. Biopsy was done under local anesthesia. After the histopathological examination of the sample the diagnosis of adenocarcinoma was made. The patient was then referred to the department of oncology. As a result of the examinations, it was found that the primary cause was lung adenocarcinoma.
Conclusion: This case report emphasizes that patients with NCS should be evaluated very carefully because this condition may be a symptom of a systemic malignancy.
References
- 1. Bruyn RP, Boogerd W. The numb chin. Clin Neurol Neurosurg. 1991;93(3):187-93.
- 2. Colella G, Giudice A, Siniscalchi G, Falcone U, Guastafierro S. Chin numbness: a symptom that should not be underestimated: a review of 12 cases. Am J Med Sci. 2009;337(6):407-10.
- 3. Eppley BL, Snyders RV, Jr. Mental neuropathy as a sign of distant malignancy: report of cases. J Oral Maxillofac Surg. 1992;50(10):1117-9.
- 4. Galán Gil S, Peñarrocha Diago M, Peñarrocha Diago M. Malignant mental nerve neuropathy: systematic review. Med Oral Patol Oral Cir Bucal. 2008;13(10):E616-21.
- 5. Aerden T, Grisar K, Neven P, Hauben E, Politis C. Numb chin syndrome as a sign of mandibular metastasis: A case report. Int J Surg Case Rep. 2017;31:68-71.
- 6. Hirshberg A, Shnaiderman-Shapiro A, Kaplan I, Berger R. Metastatic tumours to the oral cavity - pathogenesis and analysis of 673 cases. Oral Oncol. 2008;44(8):743-52.
- 7. Balamurugan N, Arathisenthil SV, Senthilkumaran S, Thirumalaikolundusubramanian P. Numb chin syndrome: A harbinger of tumor progression or relapse. Am J Emerg Med. 2017;35(5):805.e1-.e2.
- 8. Hiraki A, Nakamura S, Abe K, Takenoshita Y, Horinouchi Y, Shinohara M, et al. Numb chin syndrome as an initial symptom of acute lymphocytic leukemia: report of three cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;83(5):555-61.
- 9. Bar-Ziv J, Slasky BS. CT imaging of mental nerve neuropathy: the numb chin syndrome. AJR Am J Roentgenol. 1997;168(2):371-6.
- 10. Smith RM, Hassan A, Robertson CE. Numb Chin Syndrome. Curr Pain Headache Rep. 2015;19(9):44.
Uyuşuk Çene Sendromu: Akciğer Adenokarsinomunun Bir İşareti
Year 2021,
Volume: 12 Issue: 1, 120 - 123, 30.04.2021
Hüseyin Gülcan
,
Uğur Gülşen
Abstract
Amaç: Duyusal bir nöropati olan ve kaybı zamanda mental nöropati olarak da bilinen uyuşuk çene sendromu (UÇS), alt dudak, diş eti ve ağız mukozasında parestezi ya da his kaybı ile karakterizedir. Bu durum, malignitelerle ilişkili olabileceğinden endişe verici olarak kabul edilmektedir.
Olgu:34 yaşında kadın hasta sağ alt dudakta parestezi şikayeti ile kliniğe başvurdu. Radyografik incelemede inferior alveolar siniri içine alan bir litik lezyon tespit edildi. Lokal anestezi altında biyopsi yapıldı. Örneğin histopatolojik incelemesinin ardından adenokarsinom tanısı konuldu. Hasta daha sonra onkoloji bölümüne yönlendirildi. İncelemeler sonucunda birincil nedenin akciğer adenokarsinomu olduğu tespit edildi.
Sonuç: Bu vaka raporu UÇS’li hastaların çok dikkatli değerlendirilmesi gerektiğini vurgulamaktır çünkü bu durum bir sistemik malignitenin belirtisi olabilmektedir.
References
- 1. Bruyn RP, Boogerd W. The numb chin. Clin Neurol Neurosurg. 1991;93(3):187-93.
- 2. Colella G, Giudice A, Siniscalchi G, Falcone U, Guastafierro S. Chin numbness: a symptom that should not be underestimated: a review of 12 cases. Am J Med Sci. 2009;337(6):407-10.
- 3. Eppley BL, Snyders RV, Jr. Mental neuropathy as a sign of distant malignancy: report of cases. J Oral Maxillofac Surg. 1992;50(10):1117-9.
- 4. Galán Gil S, Peñarrocha Diago M, Peñarrocha Diago M. Malignant mental nerve neuropathy: systematic review. Med Oral Patol Oral Cir Bucal. 2008;13(10):E616-21.
- 5. Aerden T, Grisar K, Neven P, Hauben E, Politis C. Numb chin syndrome as a sign of mandibular metastasis: A case report. Int J Surg Case Rep. 2017;31:68-71.
- 6. Hirshberg A, Shnaiderman-Shapiro A, Kaplan I, Berger R. Metastatic tumours to the oral cavity - pathogenesis and analysis of 673 cases. Oral Oncol. 2008;44(8):743-52.
- 7. Balamurugan N, Arathisenthil SV, Senthilkumaran S, Thirumalaikolundusubramanian P. Numb chin syndrome: A harbinger of tumor progression or relapse. Am J Emerg Med. 2017;35(5):805.e1-.e2.
- 8. Hiraki A, Nakamura S, Abe K, Takenoshita Y, Horinouchi Y, Shinohara M, et al. Numb chin syndrome as an initial symptom of acute lymphocytic leukemia: report of three cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;83(5):555-61.
- 9. Bar-Ziv J, Slasky BS. CT imaging of mental nerve neuropathy: the numb chin syndrome. AJR Am J Roentgenol. 1997;168(2):371-6.
- 10. Smith RM, Hassan A, Robertson CE. Numb Chin Syndrome. Curr Pain Headache Rep. 2015;19(9):44.