Mantle cell lymphoma of the maxillary sinus: case report

Year 2018, , 250 - 253, 30.09.2018

Neşet Akay , Gökçe Şimşek , Selim Yalçın , Mikail İnan , Mahi Balcı , Zafer Onaran

https://doi.org/10.18663/tjcl.298836

Abstract

Mantle cell lymphoma
(MCL) is one of the many subtypes of B-cell lymphoma. Extra nodal involvement
is common and most commonly observed in bone marrow, liver, spleen, Waldeyer
ring and gastrointestinal tract. As in all malignant lymphomas excisional lymph
node biopsy is preferred for diagnosis. In early stage of MCL, radiotherapy is
considered to be a suitable treatment approach after 3-4 cycles of systemic
chemotherapy. In our case, a fifty-year-old female patient had complaints of
swelling and asymmetry on the face, propitosis with dental pain not exceeding 1
month. After radiologic evaluation, maxillary sinus biopsy was reported as
Mantle cell lymphoma. In sinonasal MHL, nonspecific symptoms such as nasal
obstruction, epistaxis, swelling on the face, rhinitis, visual impairment and
proptosis can be seen. The lymphoma should be considered in the different
diagnosis of these patients in which the symptoms are nonspecific.

Keywords

Mantle cell lymphoma, maxillary sinus, B cell tumor

Maksiller sinüsün Mantle hücreli lenfoması: olgu sunumu

Abstract

Mantle hücreli
lenfoma (MHL) çok sayıda B-hücreli lenfoma subtiplerinden biridir. Ekstra nodal
tutulum sıktır, en sık kemik iliği, karaciğer, dalak, Waldeyer halkası ve
gastrointestinal kanal tutulumu gözlenir. Tüm habis lenfomalarda olduğu gibi
tanı için eksizyonel lenf düğümü biyopsisi tercih edilir. Erken evre MHL
hastalarında 3-4 kür sistemik kemoterapi sonrası radyoterapi uygulaması uygun
bir tedavi yaklaşımı olarak görülmektedir. Bizim olgumuzda elli yaşında bayan
hastada 1 aydır geçmeyen diş ağrısı ile birlikte yüzde şişlik, asimetri, gözde
öne itilme şikayetleri mevcuttu. Radyolojik değerlendirme sonrası maksiler
sinüsten alınan biyopsi sonucu Mantle Hücreli Lenfoma olarak bildirildi. Sinonazal
MHL’de nazal obstrüksiyon, epistaksis, yüzde şişlik, rinit, görme bozukluğu ve
gözde çıkıklık gibi nonspesifik semptomlar görülebilir. Semptomların non spesifik
seyrettiği bu hastaların ayırıcı tanısında lenfoma mutlaka düşünülmelidir.

Keywords

Mantle hücreli lenfoma, maksiler sinüs, B hücreli tümör

References

• 1. Lichtman MA, Kipps TJ, Seligsohn U, Kaushansky K, Prchal JT, Editors. Pathology of malignant lymphomas. Williams Hematology. San Diego: McGraw Hill; 2010.
• 2. Fisher SG, Fisher RI. Theepidemiology of non-Hodgkin’s lymphoma. Oncogene 2004; 23: 6524-34.
• 3. Logsdon MD, Ha CS, Kavadi VS, Cabanillas F, Hess MA, Cox JD. Lymphoma of the nasal cavity and paranasal sinuses: improved outcome and altered prognostic factors with combined modality therapy. Cancer. 1997; 80: 477-88.
• 4. Bertoni F, Zucca E, Cotter FE. Molecularbasis of Mantle cell lymphoma. Br J Haematol. 2004; 124: 130-40
• 5. Cortelazzo S, Ponzoni M, Ferreri AJ, Dreyling M. Mantle cell lymphoma. Crit Rev Oncol Hematol 2012; 82: 78-101
• 6. Smith A, Howell D, Patmore R et al. İncidence of haematological malignancy by sub-type: report from the haematological malignancy research network. Br J Cancer 2011; 105: 1684-92
• 7. Moller MB, Pederson NT, Christensen BE. Mantle cell lymphoma: prognostic capaticity of The folliculer lymphoma international prognostic index. Br J Hematol 2006; 133: 43-56.
• 8. Cheah CY, George A, Gine E et al. Central nervous system involvement in mantle cell lymphoma: clinical features, prognostic factors and outcomes from the European Mantle cell lymphoma network. Ann Oncol 2013; 24: 2119-23.
• 9. Karaman E, Yilmaz M, Alimoglu Y, Edizer DT, Isildak H, Ozek H. Extranodal sinonasal natural killer / T-cell lymphoma presenting as chronic sinusitis and necrotic wound infection. J Craniofac Surg 2009; 20: 2095-96.
• 10. Sakamoto M, Miyairi Y, Ishizawa M. Optimal specimen site for diagnosis of nasal T/NK cell lymphoma and treatment including bone marrow transplantation. ORL J Otorhinolaryngol Relat Spec 2003; 65: 275-78.
• 11.Fernandez V, Salamero O, Espinet B et al. Genomic and gene expression profiling define sindolent forms of Mantle cell lymphoma. Cancer Res 2010; 70: 1408-18