Doksorubisin ile İndüklenmiş Ovaryan Toksisitede Visnaginin Koruyucu Etkisi

Year 2018, , 143 - 151, 01.12.2018

Aysun Özbay Berrin Avcı

https://doi.org/10.32708/uutfd.444964

Abstract

Doksorubisine bağlı ovaryan toksisitede ovaryan rezervi korumak
amacıyla farklı tedavi yaklaşımları uygulanmaktadır. Visnagin doksorubisine
bağlı kardiyotoksisitede tedavi edici etkinliği gösterilmiş organik bir
kimyasaldır.  Bununla birlikte
doksorubisine bağlı ovaryan toksisitede visnaginin etkinliği bilinmemektedir.
Doksorubisine bağlı ovaryan toksisitenin oluşturulduğu sıçanlarda visnaginin
tedavi edici etkinliğini değerlendiren bu çalışmada; doksorubisinin ovaryan
rezervi belirleyen primordiyal follikül sayısını, bunun yanında preantral ve
antral follikül sayısını azalttığı saptandı. İntraperitoneal 30 mg/kg visnagin
tedavisinin primordiyal follikül rezervini, gelişmekte olan ve olgun follikül
sayılarını koruduğu, atretik follikül sayısını azalttığı görüldü. Doksorubisin ile indüklenmiş ovaryan
toksisitenin visnagin tedavisi ile azaltıldığı ve ovaryan follikül rezervini
koruduğu sonucuna varıldı.

Keywords

Doksorubisin, Visnagin, Ovaryan Toksisite

Protective Effect of Visnagin on Doxorubicin-Induced Ovarian Toxicity

Abstract

Different
treatment approaches are used to for preserve ovarian reserve in ovarian
toxicity due to doxorubicin. Visnagin is an organic chemical that shows
therapeutic activity on doxorubicin-induced cardiotoxicity. However, the
efficacy of visnagin on ovarian toxicity due to doxorubicin is unknown. In this
study evaluating the therapeutic effect of visnagin in rats with ovarian
toxicity induced by doxorubicin, it was determined that doxorubicin decreased
the number of primordial follicles that determined ovarian reserve, as well as
the number of preantral and antral follicles. Intraperitoneal administration of
30 mg/kg of visnagin treatment decreased the number of atretic follicles and
preserved primordial, developing and mature follicle counts. As a result, it
was concluded that ovarian toxicity induced by doxorubicin was reduced with
visnagin treatment and the visnagin treatment preserved of ovarian follicle
reserve.

Keywords

Doxorubicin, Visnagin, Ovarian toxicity

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