Anorexigenic Peptide in the Control of Food Intake: Nesfatin-1

Yıl 2018, Cilt: 44 Sayı: 2, 135 - 142, 01.08.2018

Duygu Gök Yurtseven , Zehra Minbay , Özhan Eyigör

https://doi.org/10.32708/uutfd.447361

Cited By: 1

Öz

The sensations of hunger and fullness during the regulation of the
energy homeostasis are regulated through a complex process. This process
consists of many anorexigenic factors’ combination that inhibit food intake as
well as appetite-stimulating (orexigenic) factor. In
the last decade, many neuropeptides have been identified that alter food intake
and energy expenditure. Nesfatin-1 peptide derived from the NEFA/nucleobindin2
precursor have emerged as a hypothalamic neuropeptide suppressing
the food intake. Nesfatin-1 was first identified in the hypothalamus
and solitary tract neurons (NTS). The expression profiles in the brain areas of
NUCB2/Nesfatin-1 neurons, their effect on physiological mechanisms, and their co-localizations
with other neuropeptides are topics still studied. In the studies carried out
in our laboratory, we also have identified the location of nesfatin-1 in the
hypothalamic nuclei. In this review, in addition to the localization of
nesfatin neurons, recent literature knowledge on the physiology and functions
of nesfatin-1 peptide are included.

Anahtar Kelimeler

NUCB2, Nesfatin-1, Hypothalamic nuclei, Feeding

Besin Alımının Kontrolündeki Anoreksijenik Peptit: Nesfatin-1

Öz

Enerji homeostazının
regülasyonunda yer alan açlık ve tokluğun fizyolojik mekanizması, besin alımını
uyarıcı oreksijenik faktörlerle inhibe edici anoreksijenik çoğu faktörün
birleşiminden oluşan kompleks bir süreçle düzenlenir. Son on yılda, besin alımı
ve enerji harcanmasını değiştiren pek çok nöropeptit tanımlanmıştır.
NEFA/Nükleobindin2 prekürsöründen türeyen nesfatin-1 peptiti besin alımını
baskılayan hipotalamik nöropeptit olarak karşımıza çıkar. Nesfatin-1 ilk defa
hipotalamus ve soliter traktusta (NTS) yerleşik nöronlarda belirlenmiştir.
Nesfatin-1 nöronlarının beyin alanlarındaki ekspresyon profilleri, fizyolojik
mekanizmalar üzerindeki etkisi ve de diğer nöropeptitlerle olan kolokalizasyonları
hala üzerinde çalışılmakta olan konulardandır. Laboratuvarımızda yürütülen
çalışmalarda bizde nesfatin-1’in hipotalamik çekirdeklerdeki lokalizasyonunu
belirledik. Bu derleme makalede, nesfatin nöronlarının lokalizasyonunun yanı
sıra, nesfatin-1 peptitinin fizyolojisi ile fonksiyonlarına ait, bugüne kadar
literatürde yer alan bilgilere yer verilmiştir.

Anahtar Kelimeler

NUCB2, Nesfatin-1, Hipotalamik çekirdekler, Beslenme

Kaynakça

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