Case Report of a Rare Disease: Concomitant Renal Cell Carcinoma with Cushing's Disease

Year 2018, Volume: 44 Issue: 3, 209 - 212, 01.12.2018

Murat Çalapkulu , Özen Öz Gül , Soner Cander , Canan Ersoy , Erdinç Ertürk

https://doi.org/10.32708/uutfd.453529

Abstract

Adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma is the most common
cause of endogenous Cushing’s disease. Renal cell carcinoma (RCC) is the most
common renal cancer and there may be many endocrine abnormalities
associated with this cancer. Cushing’s syndrome can be observed in patients who
are diagnosed with renal cell carcinoma, although Cushing's disease is very
rare . The diagnosis of Cushing's disease is made by the evaluation of clinical
symptoms, endocrinological tests and radiological findings. The most effective
treatment for Cushing's disease is adenomal resection, but the chance of cure
with resection is lower in macroadenomas. Radiotherapy, medical treatments
(such as bromocriptine, cyproheptadine, ketaconazole, pasireotide) or bilateral
adrenalectomy may be considered in cases of not cured in the postoperative
period. In this report, we present a patient with a diagnosis of Cushing’s
disease and renal cell carcinoma.

Keywords

Renal cell carcinoma, Cushing's disease, ACTH-secreting adenoma

Nadir Bir Olgu: Renal Hücreli Karsinom ile Cushing Hastalığı Birlikteliği

Abstract

Hipofiz
bezinden adrenokortikotropik hormon (ACTH) salgılayan adenom, endojen Cushing hastalığının en
sık görülen nedenidir. Renal hücreli karsinom (RCC) en sık görülen böbrek
kanseridir ve bu kanser ile ilişkili birçok endokrinolojik anormallik olabilir.
Renal hücreli karsinom tanısı alan hastalarda Cushing sendromu saptanabilirken Cushing
hastalığı çok nadir görülür. Cushing hastalığının tanısı klinik
semptomlar, endokrinolojik testler ve radyolojik bulguların değerlendirilmesi
ile konur. Cushing hastalığında en etkili tedavi adenomun rezeksiyonudur ama
makroadenomlarda rezeksiyon ile kür şansı daha düşüktür. Postoperatif dönemde
kür sağlanamamış olgularda tedavi seçenekleri arasında radyoterapi, medikal
tedaviler (bromokriptin, siproheptadin, ketakonazol, pasireotide gibi) veya
bilateral adrenalektomi düşünülebilir. Burada Cushing
hastalığı ile birlikte renal hücreli karsinom tanısı konulan bir hasta
sunulacaktır.

Keywords

Renal hücreli karsinom, cushing hastalığı, ACTH salgılayan adenom

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