Metastatik Meme Kanseri Tedavisinde Lapatinib Kapesitabin Kombinasyonun Etkinliğinin Retrospektif Değerlendirilmesi

Year 2019, Volume: 45 Issue: 1, 29 - 32, 01.04.2019

Erdem Çubukçu , Birol Ocak , Ömer Fatih Ölmez , Adem Deligönül , Turgut Kaçan

https://doi.org/10.32708/uutfd.485507

Abstract

Tüm dünyada meme kanseri kadınlarda kanserin ve
kanser ilişkili ölümlerin en sık nedenidir. Meme kanserli hastaların %17–30 HER2 overekspresyonu olup hastalık kötü prognoz, hastalık progresyon riskinde
artış, genel sağkalım ve progresyona kadar geçen sürenin her ikisinde azalma
ile birliktedir. Lapatinib, HER2 ve epidermal büyüme faktör reseptör(EGFR) ün
ilk dual tirozin kinaz inhibitörüdür. Bu çalışma da antrasiklin, taksan ve
trastuzumab tedavisi sonrasında progrese olan metastatik meme kanserli
hastalarda kapesitabin ve lapatinib kombinasyonunun etkisini ve
tolerabilitesini inceledik. Medyan yaş 56 (34-76) olan toplam 24 hasta dosyası
Eylül 2010-Mayıs 2018 arasında 3 merkezde retrospektif olarak incelendi. Tüm
hastalar taksan ve antrasiklin içeren kemoterapi ve trastuzumab sonrası
progrese olan HER2 pozitif metastatik meme kanseri hastalardı. Genel cevap
oranı %29.1,  2 komplet yanıt (CR, 8.3%),
5 parsiyel yanıt (PR, 20.8%), ve 7 stabil hastalık (SD, 29.1%) olmak üzere sağlandı. Kapesitabin ve lapatinib kombinasyon tedavisi antrasiklin, taksan ve
trastuzumab tedavisi sonrasında progrese olan metastatik meme kanserli
hastalarda etkili ve iyi tolere edilmiştir.

Keywords

lapatinib, meme kanseri, metastatik

Retrospective Evaluation of the Efficacy of Lapatinib Capecitabine in the Treatment of Metastatic Breast Cancer

Abstract

Worldwide,
breast cancer is the most common malignancy and cause of cancer-related death
in women. In the 17%–30% of breast cancer patients who overexpress
ErbB2 (HER2), the disease is associated with poorer prognosis, greater risk for
disease progression and reductions in both progression free survival (PFS) and
overall survival (OS). Lapatinib is the first dual tyrosine kinase inhibitor of
human epidermal growth factor receptor type 2 (HER2/neu) and epidermal growth
factor receptor (EGFR). The present study evaluated the efficacy and
tolerability of the combination of lapatinib and capecitabine in patients with
metastatic breast cancer (MBC) who progressed after therapy with trastuzumab, a
taxane and/or anthracycline. A total of 24 patients with a
median age of 56 (34-76) were evaluated retrospectively in 3 centers between
September 2010 and May 2018. All the patients had HER2 positive MBC progressing
after trastuzumab and chemotherapy including an anthracycline and/or taxane.
An
overall response rate (ORR) of 29.1% was achieved including 2 complete
responses (CR, 8.3%), 5 partial responses (PR, 20.8%), and 7 stable disease (SD,
29.1%). Lapatinib and capecitabine combination therapy is effective and well
tolerated in patients with MBC who had progressive disease after trastuzumab,
taxane, and/or anthracycline therapy.

Keywords

lapatinib, breast cancer, metastatic

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