Altmışbeş Yaş Üstü Metastatik Yumuşak Doku Sarkom Hastalarında Pazopanib Tedavisinin Etkinliğinin Retrospektif Değerlendirilmesi.

Year 2019, Volume: 45 Issue: 1, 83 - 86, 01.04.2019

Erdem Çubukçu , Birol Ocak

https://doi.org/10.32708/uutfd.503875

Abstract

Yumuşak doku sarkomları (YDS) mezenşimal
hücrelerden köken alan tümörlerin nadir ve heterojen grububudur ve tüm erişkin
kanserlerin yaklaşık %1 ini oluşturmaktadır. YDS lerin 50 den fazla farklı
histolojik tipi mevcuttur. Pazopanib, Vasküler endotelyal büyüme faktörü reseptör 1
(VEGFR-1), VEGFR-2, VEGFR-3, trombosit kökenli büyüme faktörü a
(PDGFR-a) ve c-kit bloke eden oral kullanılan tirozin kinaz inhibitörüdür.
İlerlemiş
yumuşak doku sarkoması olan yaşlı hastalarda oral multi-tirozin kinaz
anjiyogenez inhibitörü pazopanib ile tedavi sonuçlarını geriye dönük olarak
inceledik. Medyan yaş 72 (65-79) olan toplam 13 hasta dosyası Ocak 2014-Eylül 2018
arasında retrospektif olarak incelendi. Kapesitabin ve Pazopanib
tedavisi kemoterapi sonrasında progrese olan yumuşak doku sarkomlu yaşlı
hastalarda etkili ve iyi tolere edilmiştir.

Keywords

Sarkom, Vasküler endotelyal büyüme faktör reseptör, anjiyogenez

A Retrospective Evaluation of the Efficacy of Pazopanib Treatment in Patients with Metastatic Soft Tissue Sarcoma over 65 Years

Abstract

Soft tissue sarcomas (STS) are a rare and
heterogeneous group of tumors that originate from mesenchymal cells and account
for 1% of all adult malignancies. STS is comprised of more
than 50 different histological subtypes. The primary treatments
of STS are surgery and radiotherapy. Pazopanib is an
oral-used tyrosine kinase inhibitor that blocks vascular endothelial growth
factor receptor 1 (VEGFR-1), VEGFR-2, VEGFR-3 platelet-derived growth factor
receptor (PDGFR-a), PDGFR-a, and c-kit. We retrospectively
reviewed outcomes of treatment with pazopanib, an oral multi-tyrosine kinase
angiogenesis inhibitor, in oldest patients with advanced soft tissue sarcoma. A total of 13 patients with a median age of 72
(65-79)  were evaluated retrospectively
in between January 2014 and September 2018. Pazopanib therapy is effective and
well tolerated in oldest patients with STS who had progressive disease after chemotherapy.

Keywords

Sarcoma, vascular endothelial growth factor receptor, angiogenesis

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