İmmunoterapi ve Radyoterapi Kombinasyonu

Süreyya Sarıhan

doi:10.32708/uutfd.710919

Review

Immunotherapy and Radiotherapy Combination

Year 2020, Volume: 46 Issue: 2, 225 - 235, 01.08.2020

Süreyya Sarıhan

https://doi.org/10.32708/uutfd.710919

Cited By: 1

Abstract

Immunotherapy is a treatment proven to be effective in terms of response, duration of response and survival in many types of cancer by strengthening the immune system. The response rates are 20%, and new treatments that produce synergistic effect with immunotherapy are needed in resistant patients. Antigenic stimulation released from tumor cells with radiotherapy can complement immunotherapy by making the tumor more easily recognized by the immune system. The systemic effect of radiotherapy on metastases other than the irradiated target is defined as “abscopal” effect and the main purpose of immuno-radiotherapy is to evoke the “abscopal” effect. The significant contribution of immuno-radiotherapy to response and survival has been shown primarily in malignant melanoma and lung cancers, and is seen as a promising treatment method in other solit tumors as well.

Keywords

immunotherapy, radiotherapy, combined modality therapy

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İmmunoterapi ve Radyoterapi Kombinasyonu

Year 2020, Volume: 46 Issue: 2, 225 - 235, 01.08.2020

Süreyya Sarıhan

https://doi.org/10.32708/uutfd.710919

Cited By: 1

Abstract

İmmunoterapi, bağışıklık sisteminin güçlendirilmesi ile birçok kanser türünde yanıt, yanıt süresi ve sağkalım açısından etkinliği kanıtlanmış bir tedavidir. Yanıt oranları %20 olup dirençli hastalarda immunoterapi ile sinerjik etki yaratan yeni tedavilere gereksinim vardır. Radyoterapi ile tümör hücrelerinden salınan antijenik uyarı tümörün bağışıklık sistemi tarafından daha kolay tanınmasını sağlayarak immunoterapinin tamamlayıcısı olabilir. Radyoterapinin, ışınlanan hedef dışındaki metastazlar üzerindeki sistemik etkisi “abscopal” etki olarak tanımlanmış olup immuno-radyoterapinin temel amacı “abscopal” etkiyi uyandırmaktır. İmmuno-radyoterapinin yanıt ve sağkalıma anlamlı katkısı öncelikle malign melanom ve akciğer kanserlerinde gösterilmiş olup diğer solid tümörlerde de gelecek vaat eden önemli bir tedavi yöntemi olarak görülmektedir.

Keywords

immunoterapi, radyoterapi, kombine model tedavi

References

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4. Eton O, Legha SS, Bedikian AY, et al. Sequential biochemotherapy versus chemotherapy for metastatic melanoma: results from a phase III randomized trial. J Clin Oncol, 2002; 20 (8): 2045-52.
5. Hamid O, Robert C, Daud A, et al. Five-year survival outcomes for patients with advanced melanoma treated with pembrolizumab in KEYNOTE-001. Ann Oncol, 2019; 30 (4): 582-588.
6. Ascierto PA, Long GV, Robert C, et al. Survival Outcomes in Patients With Previously Untreated BRAF Wild-Type Advanced Melanoma Treated With Nivolumab Therapy: Three-Year Follow-up of a Randomized Phase 3 Trial. JAMA Oncol, 2019; 5 (2): 187-194.
7. www.nccn.org
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9. Eggermont AM, Chiarion-Sileni V, Grob JJ, et al. Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomised, double-blind, phase 3 trial. Lancet Oncol, 2015; 16 (5): 522-30.
10. Eggermont AMM, Chiarion-Sileni V, Grob JJ, Adjuvant ipilimumab versus placebo after complete resection of stage III melanoma: long-term follow-up results of the European Organisation for Research and Treatment of Cancer 18071 double-blind phase 3 randomised trial. Eur J Cancer, 2019; 119: 1-10.
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16. Bradley JD, Hu C, Komaki RR, et al. Long-Term Results of NRG Oncology RTOG 0617: Standard- Versus High-Dose Chemoradiotherapy With or Without Cetuximab for Unresectable Stage III Non-Small-Cell Lung Cancer. J Clin Oncol, 2020; 38 (7): 706-714.
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23. Dovedi SJ, Adlard AL, Lipowska-Bhalla G, et al. Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade. Cancer Res, 2014; 74:5458–5468.
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Details

Primary Language	Turkish
Subjects	Oncology and Carcinogenesis
Journal Section	Review Articles
Authors	Süreyya Sarıhan 0000-0003-4816-5798
Publication Date	August 1, 2020
Acceptance Date	June 17, 2020
Published in Issue	Year 2020 Volume: 46 Issue: 2

Cite

APA	Sarıhan, S. (2020). İmmunoterapi ve Radyoterapi Kombinasyonu. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 46(2), 225-235. https://doi.org/10.32708/uutfd.710919
AMA	Sarıhan S. İmmunoterapi ve Radyoterapi Kombinasyonu. Uludağ Tıp Derg. August 2020;46(2):225-235. doi:10.32708/uutfd.710919
Chicago	Sarıhan, Süreyya. “İmmunoterapi Ve Radyoterapi Kombinasyonu”. Uludağ Üniversitesi Tıp Fakültesi Dergisi 46, no. 2 (August 2020): 225-35. https://doi.org/10.32708/uutfd.710919.
EndNote	Sarıhan S (August 1, 2020) İmmunoterapi ve Radyoterapi Kombinasyonu. Uludağ Üniversitesi Tıp Fakültesi Dergisi 46 2 225–235.
IEEE	S. Sarıhan, “İmmunoterapi ve Radyoterapi Kombinasyonu”, Uludağ Tıp Derg, vol. 46, no. 2, pp. 225–235, 2020, doi: 10.32708/uutfd.710919.
ISNAD	Sarıhan, Süreyya. “İmmunoterapi Ve Radyoterapi Kombinasyonu”. Uludağ Üniversitesi Tıp Fakültesi Dergisi 46/2 (August 2020), 225-235. https://doi.org/10.32708/uutfd.710919.
JAMA	Sarıhan S. İmmunoterapi ve Radyoterapi Kombinasyonu. Uludağ Tıp Derg. 2020;46:225–235.
MLA	Sarıhan, Süreyya. “İmmunoterapi Ve Radyoterapi Kombinasyonu”. Uludağ Üniversitesi Tıp Fakültesi Dergisi, vol. 46, no. 2, 2020, pp. 225-3, doi:10.32708/uutfd.710919.
Vancouver	Sarıhan S. İmmunoterapi ve Radyoterapi Kombinasyonu. Uludağ Tıp Derg. 2020;46(2):225-3.

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Radiotherapy could increase the efficacy of immunotherapy in non-small cell lung cancer

Turkish Journal of Internal Medicine

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