Drosophila melanogaster Model in Neurodegenerative Disease Research

Year 2020, Volume: 46 Issue: 2, 237 - 245, 01.08.2020

Cem Hazır Gamze Bora , Hayat Erdem Yurter

https://doi.org/10.32708/uutfd.732671

Cited By: 1

Abstract

Modelling human diseases in Drosophila melanogaster have been accelerated advances in many areas including investigations on pathophysiology, identification of new genes and genetic modifiers, explanations of clinic variability, development of new diagnosis and treatment approaches and drug investigations. In this review, advantages of D. melanogaster as a model organism and its use in neurodegenerative diseases are discussed.

Modelling human diseases in Drosophila melanogaster have been accelerated advances in many areas including investigations on pathophysiology, identification of new genes and genetic modifiers, explanations of clinic variability, development of new diagnosis and treatment approaches and drug investigations. In this review, advantages of D. melanogaster as a model organism and its use in neurodegenerative diseases are discussed.

Keywords

Drosophila melanogaster, model organism, neurodegenerative disease, genetics

Nörodejeneratif Hastalık Araştırmalarında Drosophila melanogaster Modeli

Abstract

İnsan hastalıklarının Drosophila melanogaster’de modellenmesi sayesinde, patofizyolojilerin araştırılması, yeni genlerin ve genetik düzenleyicilerin tanımlanması, klinik çeşitlilik nedenlerinin açıklanabilmesi, yeni tanı ve tedavi yaklaşımlarının geliştirilmesi, ilaç araştırma çalışmalarının yapılabilmesi gibi birçok alandaki gelişmeler hız kazanmıştır. Bu derlemede D. melaonogaster’in model organizma olarak avantajları ve nörodejeneratif hastalıklarla ilişkili araştırmalarda kullanılmasına ilişkin bilgiler verilmektedir.

Keywords

Drosophila melanogaster, model organizma, nörodejeneratif hastalık, genetik

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