Otoimmün Hastalıkların Tedavisi İçin Yeni Bir Umut: Piperin

Year 2024, Volume: 50 Issue: 2, 357 - 366, 08.10.2024

Ali Eren Işkın , Abdurrahman Şimşek , Ferah Budak

https://doi.org/10.32708/uutfd.1460014

Abstract

Çoğunlukla tropikal ve subtropikal bölgelerde yetiştirilen ve "Piperaceae" familyasında yer alan Piper nigrum, ‘‘Baharatların kralı’’ olarak kabul edilen bir bitkidir. Uzun biberin ve karabiberin acı tadından sorumlu olan ve doğal bir bileşik olarak tanımlanan piperin, P. nigrum’da bulunan bir alkaloiddir. Piperinin, gıda koruyucusu ve bir gıda bileşeni olarak kullanılmasının yanı sıra immünomodülatör, antikanser, antioksidan, nöroprotektif ve antienflamatuvar gibi özellikleri nedeniyle geleneksel tıpta kullanılmaktadır. P. nigrum ve Piper longum gibi doğal ürünlerden elde edilen bileşiklerin nörodejeneratif, kanser, otoimmün ve kronik hastalıkların tedavisinde kullanılması nedeniyle çok sayıda araştırmanın odak noktası haline gelmiştir. Bu derlemedeki amacımız, otoimmün hastalıklarda piperin bileşiğinin terapötik olarak kullanılabilirliğini değerlendirmektir.

Keywords

Karabiber, Piperin, Alkaloid, Otoimmünite, Otoimmün Hastalıklar

Ethical Statement

İlgili çalışmanın derleme yayını olması nedeniyle etik kurul onayı gerekmemektedir.

Supporting Institution

İlgili çalışmamız için finansal desteğe ihtiyaç duyulmamıştır.

A New Hope for the Treatment of Autoimmune Diseases: Piperine

Abstract

Piper nigrum, which is mostly grown in tropical and subtropical regions and belongs to the "Piperaceae" family, is a plant considered as the "King of spices". Piperine, a natural compound responsible for the bitter taste of long pepper and black pepper, is an alkaloid found in P. nigrum. In addition to its use as a food preservative and a food ingredient, piperine is used in traditional medicine for its immunomodulatory, anticancer, antioxidant, neuroprotective and anti-inflammatory properties. Compounds derived from natural products such as P. nigrum and Piper longum have become the focus of numerous studies due to their use in the treatment of neurodegenerative, cancer, autoimmune and chronic diseases. Our aim in this review is to evaluate the therapeutic utility of piperine compound in autoimmune diseases.

Keywords

Black Pepper, Piperine, Alkaloid, Autoimmunity, Autoimmune Diseases

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