Evaluation of the effect of ozone therapy on the treatment of cutaneous wounds with tissue-loss in dogs and cats

Year 2022, Volume: 7 Issue: 3, 313 - 320, 31.12.2022

Osman Aydın , Ali Kumandaş

https://doi.org/10.31797/vetbio.1104760

Abstract

The aim of this study was to investigate the effects of ozone treatments on the rapid and uncomplicated recovery of the wound or the shortening of the time of suture placement. This study was carried out on a total of 40 patients who were admitted to our surgery clinic with 20 cats and 20 dogs of different ages, races, and genders. These animals were divided into 4 groups. According to the statistics obtained; The patients in group 1 (ozonated oil) had the best reduction in wound size and clinical efficacy. This group was followed by group 3, which was supported by treatment with ozonated water. There was no statistically significant difference in both ozone bagging and control groups. As a result, it was observed that in addition to the treatment of skin wounds with tissue loss, ozonated oil or ozonated water accelerated healing by 50% on average.

Keywords

Ozone bagging, Ozonated oil, Ozonated water, Skin wound with tissue-loss

Project Number

Yok

References

• Anderson, D. (1996). Wound management in small animal practice, In Pract, 18, 115-128.
• Beanes, S.R., DANG, C., Soo, C., Ting, K. (2003). Skin repair and scar formation: the-central role of TGF-β, Expert. Rev. Mol. Med, 5 (21), 1-11.
• Bette, M., Nusing, R.M., Mutters, R., Zamora, Z.B., Menendez, S., Schulz, S. (2006). Efficiency of tazobactam/piperacilin in lethal peritonitis is enhanced after preconditioning of rats with O3/O2-pneumoperitoneum, Shock, 25, 23-29.
• Bocci, V. (1999). Biological and clinical effects of ozone: has ozone therapy a future in medicine?, British Journal of Biomedical Science, 56, 270-279.
• Bocci, V. (2006). Scientific and medical aspects of ozone therapy. State of the art. Archives of Medical Research, 37, 425–435.
• Bocci, V., Larini, A., Micheli, V. (2005). Restorationnof normoxia by ozone therapy may control neoplastic growth: a review and a working hypothesis, The Journal of Alternative and Complementary Medicine, 11 (2), 257-265.
• Bohling, M.W., Henderson, R.A., Swaim, S.F., Kincaid, S.A., Wright, J.C. (2004). Cutaneous wound healing in the cat: A macroscopic description and comparison with-cutaneous wound healing in the dog, Vet. Surg, 33, 579-587.
• Clavo, B., Perez, J.L., Lopez, L., Suarez, G., Lloret, M., Rodriguez, V., Marias, D., Santana, M., Hernandez, M.A., Martin-Oliva, R., Robaina, F. (2004). Ozone therapy for tumor oxygenation: a pilot study, Evidence-based Complementary and Alternative Medicine, 1(1), 93-98.
• Diegelmann, R.F., Evans, M.C. (2004). Wound healing: an overview of acute, fibrotic-and delayed healing, Front. Biosci, 9, 283-289.
• Dinçer, S., Babul, A., Erdoğan, D., Özgül, L., Dinçer, S.L. (1996). Effect of-Taurine on Wound Healing, Aminoacids, 10, 59-71.
• Engin, A. (2004). Yara iyileşmesi, In İ. Sayek (Ed.), Temel Cerrahi, pp. (266-277). Güneş Kitabevi, Ankara.
• Glenn, F.B., Thomas, A.M. (1995). Pharmacologic enhancement of wound healing, Annu Rev. Med, 46, 467-481.
• Gornicki, A., Gutsze, A. (2000). In vitro effects of ozone on human erythrocyte membranes: An EPR study. Acta Biochimica Polonica, 47(4), 963-971.
• Güzel, Ö., Yıldar, E., Erdikmen, D.O. (2011). Medikal ozon ve veteriner cerrahide kullanımı, Vet. Fak. Derg. Med., 37(2), 177-184.
• Khadre, M.A., Yousef, A.E., Kim J.G. (2001). Microbiological aspects of ozone applications in food:a review, Journal of Food Scıence, 66(9), 1242-1252.
• Kim, H.S., Noh, S.U., Han, Y.W., Kim, K.M., Kang, H., Kim, H.O., Park, Y.M. (2009). Therapeutic effects of topical application of ozone on acute cutaneous wound healing. Journal of Korean Medical Science 24, 368-374.
• Kirsner, R.S., Eaglsterin, W.H. (1993). The wound healing process, Dermatol. Clin, 11(4), 629-640.
• Kuroda, K., Azuma, K., Mori, T., Kawamoto, K., Murahata, Y., Tsuka, T., Osaki, T., Ito, N., Imagawa, T., Itoh, F., Okamoto, Y. (2015). The safety and anti-tumor effects of ozonated water in vivo, International Journal of Molecular Sciences, 16, 25108-25120.
• Kutlubay, Z., Engin, B., Serdaroğlu, S., Tüzün, Y. (2010). Dermatolojide ozon tedavisi, DERMATOZ, 1(4), 209-216.
• Li, J., Chen, J., Kirsner, R. (2007). Pathophysiology of acute wound healing, Clin. Dermatol, 25, 9-18.
• Nogales, C.G., Ferrari, P.A., Kantorovich, E.O., Lage-Marques, J.L. (2008). Ozone therapy in medicine and dentistry, The Journal of Contemporary Dental Practice, 9(4), 75-84.
• Philips, S.J. (2000). Physiology of wound healing and surgical wound care, ASAIO Journal, 46, 2-5.
• Polat, H. (2009). Dezenfeksiyon amaçlı ozon kullanımı, Yunus Araştırma Bülteni, 9(2), 14-15.
• Rigler, D.J. (1997). Inflamation and repair, In T.C. Jones, R.D. Hunt, N.W. King, (Eds.), Veterinary Pathology, (pp.150-157).
• Shinuzuka, Y., Uemetsu, K., Takagi, M., Taura, Y. (2008). Comparison of the amounts of endotoxin released from Escherichia coli after exposure to antibiotics and ozone: an In Vitro evaluation, Journal of Veterinary Medical Science, 70(4), 419-422.
• Theoret, C.L. (2004). Wound repair in the horse: Problems and proposed innovative-solutions, Clin. Tech. Equine. Pract, 3;134-140. doi:/10.1053/j.ctep.2004.08.010
• Travagli, V., Zanardi, I., Valacchi, G., Bocci, V. (2010). Ozone and ozonated oils in skin diseases: A review. Mediators of Inflammation, doi:/10.1155/2010/610418
• Valacchi, G., Fortino, V., Bocci, V. (2005). The dual action of ozone on the skin, Br J Dermatol, 153, 1096-1100.
• Wilmink, J.M., Van Weeren, P.R. (2004). Differences in wound healing between horses and-ponies: application of research results to the clinical approach of equine wounds, Clin. Tech. Equine. Pract, 3; 123-133.
• Witte, M.B., Burbul, A. (1997). General principles of wound healing, Surg. Clin. N.Amer, 77; 509-258.
• Zamora, Z. B., Menéndez, S., Bette, M., Mutters, R., Hoffmann, S., & Schulz, S. (2003, August). Ozone Prophylactic Effect and Antibiotics as a Modulator of Inflamatory Septic process in Rats. In Proceedings of the 16th International Ozone Association World Congress, Las Vegas, NV, USA (p. 123). https://medicalozone.info/wp-content/uploads/Ozone-Therapy-Sepsis.pdf