Clinical success of clarithromycin, amoxicillin-clavulanic acid, enrofloxacin and doxycycline in dogs with infectious tracheobronchitis

Year 2023, Volume: 8 Issue: 3, 210 - 215, 15.12.2023

Ali Evren Haydardedeoğlu , Ekrem Çağatay Çolakoğlu , Hadi Alıhosseını , Ufuk Kaya

https://doi.org/10.31797/vetbio.1336336

Abstract

Canine infectious tracheobronchitis (ITB) is a highly contagious disease of dogs expressed with remarkable respiratory signs. Therapy with antibiotics in canine ITB still remains questionable. The purpose of this study was to compare the clinical success of clarithromycin, amoxicillin-clavulanic acid, enrofloxacin and doxycycline in the treatment of canine ITB. Client-owned dogs with canine ITB signs (n=60) were enrolled in this prospective, controlled, and randomized blinded clinical trial. A computer-generated list randomization was employed to assign the dogs equally into the Group CLA: clarithromycin (25 mg/kg, PO), the Group AMX: amoxicillin and clavulanic acid (25 mg/kg, PO), the Group ENR: enrofloxacin (2.5 mg/kg, PO), and the Group DOX: doxycycline (5 mg/kg, PO). The administration of CLA alleviated the cough sign earlier than DOX. The recovery time of oculonasal discharge in group CLA were also earlier compared to the other groups. The tracheal sensitivity also disappeared earlier in the Groups CLA and AMX. In conclusion although there is no always statistically significance between groups, clarithromycin appears to be superior to other antibiotics suggesting that it can be the first antibiotic choice to alleviate the ITB signs in dogs.

Keywords

Antibiotics, dog, infection, tracheobronchitis

References

• Angus, J.C, Jang, S.S., & Hirsh, D.C. (1997). Microbiological study of transtracheal aspirates from dogs with suspected lower respiratory tract disease: 264 cases (1989-1995). Journal of the American Veterinary Medical Association, 210, 55-58.
• Ettinger, S.J., & Kantrowitz, B. (2000). Textbook of Veterinary Internal Medicine (2nd ed.). Elsevier, New York.
• Evangelos, J.G., Peche, J.C., Routsi, C., Plachouras, D., Kollias, S., Raftogiannis, M., Zervakis, D., Baziaka, F., Koronaios, A., Antonopoulou, A., Markaki, V., Koutoukas, P., Papadomichelakis, E., Tsaganos, T., Armaganidis, A., Koussoulas, V., Kotanidou, A., Roussos, C., & Giamarellou, H. (2008). Effect of clarithromycin in patients with sepsis and ventilator-associated pneumonia. Clinical Infectious Disease, 46, 1157–1164. https://doi.org/10.1086/529439
• Ford, R.B., & Vaden, S.L. (1998). Canine infectious tracheobronchitis. In J. Sykes, C. Greene (Eds.), Infectious diseases of the dog and cat (pp. 33-38). Saunders.
• Ford, R.B. (2012). Infectious disease of dog and cat (4th ed.). Elsevier, New York.
• Ford, R.B. (1995). Infectious tracheobronchitis. In J.D. Bonagura, R.W. Kirk (Eds.), Kirk’s Current Veterinary Therapy (pp. 905-908). Saunders.
• Hawkins, E.C. (2009). Textbook of Small Animal Internal Medicine. Elsevier, New York.
• Kaczorek, E., Schulz, P., Małaczewska, J., Wojcik, R., Siwicki, A., Stopyra, A., Lew-Kojrys, S., Pomianowski, A., Hryniewicka, K., & Mikulska-Skupien, E. (2016). Prevalence of respiratory pathogens detected in dogs with kennel cough in Poland. Acta Veterinaria Brno, 85, 329-336. https://doi.org/10.2754/avb201685040329
• Köse, S., Maden, M., & Sayın, Z. (2022). Clinical and bacteriological analysis of respiratory tract infections in sheltered dogs and determination of antibacterial treatment options. Journal of the Hellenic Veterinary Medical Society, 72(4), 3491–3502. https://doi.org/10. 12681/jhvms.29441
• Langtry, H.D., & Brogden, R.N. (1997). Clarithromycin. Drugs, 53, 973-1004.
• Lappin, M.R., Blondeau, J., Boothe, D., Breitschwerdt, E., Guardabassi, L., Lloyd, D., Papich, M., Rankin, S., Skyes, J., Turnidge, J., & Weese, J. (2017). Antimicrobial use guidelines for treatment of respiratory tract disease in dogs and cats: Antimicrobial guidelines working group of the ınternational society for companion animal ınfectious diseases. Journal of Veterinary Internal Medicine, 31, 279–294. https://doi.org/10.1111/jvim.14627
• Nelson, R.W., & Couto, C.G. (2009). Small Animal Internal Medicine (4th ed.) Saunders, New York.
• Petersen, M.E., & Kutzler, M.A. (2012). Small Animal Pediatrics. The First 12 Months of Life (1st ed.) Saunders, New York.
• Priestnall, S.L., Mitchell, J.A., Walker, C.A., Erles, K., & Brownlie, J. (2014). New and emerging pathogens in canine infectious respiratory disease. Veterinary Pathology, 51, 491-504. https://doi.org/10.1177/ 03009858135111
• Reagan, K.L., & Jane E.S. (2020). Canine infectious respiratory disease. Veterinary Clinics: Small Animal Practice, 50, 2, 405-418. https://doi.org/10.1016/j. cvsm.2019.10.009
• Speakman, A.J., Dawson, S., Corkill, J.E., Binns, S.H., Hart, C.A., & Gaskell, R.M. (2000). Antibiotic susceptibility of canine Bordetella bronchiseptica isolates. Veterinary Microbiology, 71, 193-200. https://doi.org/10.1016/S0378-1135(99) 00171-6
• Thrusfield, M.V., Aitken, C.G.G., & Muirhead, R.H. (1991). A field investigation of kennel cough: Incubation period and clinical signs. Journal of Small Animal Practice, 32, 215-220. https://doi.org/10.1111 /j.1748-5827.1991.tb00550.x
• Vilmgnyi, E., Kung, K., Riond, J.L., Trümpi, B., & Wannes, M. (1991). Clarithromycin pharmacokinetics after oral administration with or without fasting in crossbred beagles. Journal of Small Animal Practice, 11, 535-539. https://doi.org/10.1111/j.1748-5827. 1996.tb02314.x