Dittrichia viscosa (L.) Greuter (Dv) has antimicrobial, analgesic, antioxidant, anti-inflammatory, cytotoxic, and wound-healing properties. We aimed to prepare the methanol extract (Dv-Me) of the aerial parts of Dv and to determine its antioxidant capacity by FRAP, CUPRAC, and DPPH methods. In addition, we prepared nanoemulsion (NE) and NE-based gel (NEG) formulations containing Dv-Me for topical application to the skin for wound healing and characterized these formulations in vitro. The antioxidant capacity of Dv-Me was determined by CUPRAC, FRAP, and DPPH methods. Then, NE formulations with/without extract (B-NE and Dv-Me-NE) were developed and in vitro characterized [morphological analysis; centrifuge test; viscosity and pH measurements; FT-IR analysis; the determination of zeta potential, droplet size and polydispersity index (PDI)]. Besides, B-NEG and Dv-Me-NEG were prepared and in vitro characterized [FT-IR analysis; viscosity and pH measurements]. The droplet size and zeta potential values of NE formulations were smaller than 185 nm and around -30 mV, respectively. PDI values were found to be less than 0.3. The pH values of Dv-Me-NE and Dv-Me-NEG were found to be 5.13±0.01 and 5.87±0.02, respectively. The NE and NEG formulations showed Newtonian and pseudoplastic behaviors, respectively. As a result, Dv-Me-NEG exhibits the desired pseudoplastic behavior for topical application to the skin.
Dittrichia viscosa in vitro studies Methanol extract Nanoemulsion Nanoemulsion-based gel
Ethics committee approval was not required for this study because of there was no study on animals or humans.
Dittrichia viscosa (L.) Greuter (Dv) has antimicrobial, analgesic, antioxidant, anti-inflammatory, cytotoxic, and wound-healing properties. We aimed to prepare the methanol extract (Dv-Me) of the aerial parts of Dv and to determine its antioxidant capacity by FRAP, CUPRAC, and DPPH methods. In addition, we prepared nanoemulsion (NE) and NE-based gel (NEG) formulations containing Dv-Me for topical application to the skin for wound healing and characterized these formulations in vitro. The antioxidant capacity of Dv-Me was determined by CUPRAC, FRAP, and DPPH methods. Then, NE formulations with/without extract (B-NE and Dv-Me-NE) were developed and in vitro characterized [morphological analysis; centrifuge test; viscosity and pH measurements; FT-IR analysis; the determination of zeta potential, droplet size and polydispersity index (PDI)]. Besides, B-NEG and Dv-Me-NEG were prepared and in vitro characterized [FT-IR analysis; viscosity and pH measurements]. The droplet size and zeta potential values of NE formulations were smaller than 185 nm and around -30 mV, respectively. PDI values were found to be less than 0.3. The pH values of Dv-Me-NE and Dv-Me-NEG were found to be 5.13±0.01 and 5.87±0.02, respectively. The NE and NEG formulations showed Newtonian and pseudoplastic behaviors, respectively. As a result, Dv-Me-NEG exhibits the desired pseudoplastic behavior for topical application to the skin.
Dittrichia viscosa in vitro studies Methanol extract Nanoemulsion Nanoemulsion-based gel
Ethics committee approval was not required for this study because of there was no study on animals or humans.
Birincil Dil | İngilizce |
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Konular | Nanoteknoloji (Diğer) |
Bölüm | Research Articles |
Yazarlar | |
Yayımlanma Tarihi | 15 Mart 2025 |
Gönderilme Tarihi | 13 Aralık 2024 |
Kabul Tarihi | 27 Ocak 2025 |
Yayımlandığı Sayı | Yıl 2025 Cilt: 8 Sayı: 2 |