Hemin İlavesinin Laktik Asit Bakterilerinde Oksidatif Stres Üzerine Etkisi

Yıl 2016, Cilt: 31 Sayı: 2, 35 - 42, 29.07.2016

Burcu Özel Ömer Şimşek Hüseyin Erten

Öz

Laktik asit bakterileri diğer bakteriler gibi gerek in vitro gerekse in vivo koşullarda üreme ve gelişme süreçlerinde birçok stres faktörü ile karşılaşırlar. Bunlardan biri de oksidatif strestir. Oksidatif stres laktik asit bakterilerinin mikrobiyal gelişimi ve metabolit üretme yeteneklerini olumsuz etkiler. Katalaz negatif özellikli laktik asit bakterilerinin oksijene karşı hassasiyetlerinin azaltılmasında bugüne kadar çeşitli moleküler çalışmalar yapılmıştır. Öte yandan, üretici suşun genetik doğasında herhangi bir değişiklik yapmadan kültür ortamına hemin ilavesi ile de oksidatif stres ortadan kaldırılabilinir. Bu derlemede; laktik asit bakterilerinde görülen oksidatif stresin hücre tarafından elemine edilmesinde etkili olan hemin ve hemin ilavesinin hücredeki etki mekanizması üzerinde durulmuştur.

Anahtar Kelimeler

Laktik asit bakterileri, oksidatif stres, hemin, solunum

Influence Of Hemin Addition On Oxidative Stress In Lactic Acid Bacteria

Öz

Lactic acid bacteria as much as other bacteria are faced to many stress factors during their growth and development process in vitro and in vivo conditions. Oxidative stress represents one of these stress factors. Oxidative stress negatively affects microbial growth and metabolite production of lactic acid bacteria. Many molecular studies have been done on the reduction of oxygen sensitivity of lactic acid bacteria which have catalase negative property. However, addition of hemin into the fermentation medium can prevent the oxidative stress of lactic acid bacteria without doing any genetic modification. In this review, hemin structure and addition of hemin for the elimination of oxidative stress by the cell occurring in lactic acid bacteria were discussed

Anahtar Kelimeler

Lactic acid bacteria, oxidative stress, hemin, respiration

Kaynakça

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