GIDA KATKI MADDELERİ VE GENETİK ETKİLERİ

Yıl 2024, Cilt: 49 Sayı: 1, 1 - 24, 14.02.2024

Ece Çelik Atalay , Adviye Gülçin Sağdıçoğlu Celep

https://doi.org/10.15237/gida.GD23078

Öz

Gıda katkı maddeleri, gıdanın güvenliğini, tazeliğini, lezzetini, dokusunu veya görünümünü korumak veya geliştirmek amacıyla kullanılan maddelerdir. İşlenmiş gıda tüketimi arttıkça, gıda katkı maddelerinin tüketimi de artmıştır. Çalışmalar, yüksek dozlarda ve uzun süre maruz kalmanın canlı organizmalarda toksik, genotoksik, mutajenik etkilere ve üreme, gelişimsel, immünotoksisite gibi bozukluklara neden olabileceğini göstermektedir. Gıda katkı maddelerinin genotoksik etkilerine ilişkin bazı tartışmalar devam etmektedir. Önerilen dozlarda kullanımlarının genellikle güvenli olduğu kabul edilirken, bazı gıda katkı maddelerinin önerilen günlük alım miktarını aşabileceğine dair kanıtlar bulunmaktadır. Ayrıca, gıda katkı maddelerinin vücutta birikmesi olasılığına dikkat çekilmekte ve bu birikimin genetik materyal üzerinde toksik etkilere ve olumsuz sağlık sonuçlarına yol açabileceği vurgulanmaktadır. Bu derleme, özellikle yaygın kullanılan bazı gıda katkı maddelerinin genotoksik etkilerini araştıran güncel çalışmaların bir özetini sunmaktadır.

Anahtar Kelimeler

gıda katkı maddeleri, genotoksisite, gıda güvenliği

Teşekkür

Ece ÇELİK ATALAY'a 100/2000 özel burs programı kapsamında burs sağlayan Yükseköğretim Kurulu'na (YÖK) teşekkür ederiz. Ece ÇELİK ATALAY ayrıca BİDEB/2211-A doktora burs programı kapsamında Türkiye Bilimsel ve Teknolojik Araştırma Kurumu (TÜBİTAK) tarafından sağlanan mali desteğe teşekkür eder.

FOOD ADDITIVES AND GENETIC INFLUENCES

Öz

Food additives are substances used to preserve or improve the safety, freshness, flavor, texture or appearance of food. As the consumption of processed food has increased, so has the consumption of food additives. Studies show that high doses and prolonged exposure can cause toxic, genotoxic, mutagenic effects and disorders such as reproductive, developmental and immunotoxicity in living organisms. The debate on the genotoxic effects of food additives continues. While their use at recommended doses is generally considered safe, there is evidence that some food additives may exceed the recommended daily intake. Furthermore, the possibility of accumulation of food additives in the body has been highlighted, which may lead to toxic effects on genetic material and adverse health outcomes. This review provides a summary of recent studies investigating the genotoxic effects of some common food additives.

Anahtar Kelimeler

food additives, genotoxicity, food safety

Kaynakça

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