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FONKSİYONEL BİR ÜRÜN OLAN PROPOLİSİN SAĞLIK ÜZERİNE ETKİSİ

Yıl 2020, Cilt: 20 Sayı: 2, 189 - 208, 09.11.2020
https://doi.org/10.31467/uluaricilik.770477

Öz

Propolis bal arıları tarafından çam, okaliptüs, akçaağaç, kavak, kestane, erik gibi ağaçların tomurcuk, yaprak ya da kabuk çatlaklarından topladığı bitki reçinelerinin mum ile karıştırılmasıyla üretilen ve kovanda çeşitli amaçlarla kullanılan bir arı ürünüdür. Yapısında bulunan galangin, luteolin, kafeik asit fenil ester, krisin, ferulik asit gibi biyolojik aktiviteye sahip bileşenler insan sağlığının korunmasında büyük öneme sahiptir. Günümüzde her altı kişiden birinin ölümüne sebep olan kanserin tedavisi ve iyileşme sürecinin desteklenmesinde propolisin faydası kanıtlanmıştır. Bunun yanında antimikrobiyal, antiviral, antifungal, antioksidan özelliği ile gıdaların korunması ve fonksiyonel özelliğinin arttırılmasına yardımcı olmaktadır. Bu faydalı özellikleri nedeniyle fonksiyonel gıda üretiminde, kozmetik sanayinde, ilaç sanayinde ve destekleyici bir tedavi olan apiterapide kullanılmaktadır.

Destekleyen Kurum

Süleyman Demirel Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi

Proje Numarası

FDK-2019-6924

Teşekkür

Bu çalışma Süleyman Demirel Üniversitesi Bilimsel Araştırma Projeleri (SDÜ-BAP) Koordinasyon Birimi tarafından FDK-2019-6924 No’lu proje ile doktora tez çalışması kapsamında desteklenmiştir. Desteklerinden dolayı SDÜ-BAP birimine teşekkür ederiz.

Kaynakça

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The Effect of Propolis as a Functional Product on Health

Yıl 2020, Cilt: 20 Sayı: 2, 189 - 208, 09.11.2020
https://doi.org/10.31467/uluaricilik.770477

Öz

Propolis is used plant resins collected by honey bees from the buds, leaves or shell cracks of trees such as pine, eucalyptus, maple, poplar, chestnut, plum; wax is a bee product produced by mixing bees with various secretions and partially with pollen and used for various purposes in the hive. The components in its structure gave the propolis antimicrobial, antitumoral, antifungal and antiseptic properties. For this reason, it has been used for the healing of wounds, the treatment of dental caries or disinfection since ancient times. Today, the use of propolis, which is determined to support the immune system, has become more common. The availability of many products produced using propolis has also facilitated its usability. Products such as cream, lotion, and toothpaste produced in recent years contribute positively to the treatment of various diseases. Especially in recent years, the use of propolis in the treatment and recovery of cancer that causes the death of one out of every six people has drawn attention and many studies have been conducted on this subject. Propolis is also used in different areas such as healing wounds, eliminating dermatological problems, protecting oral and dental health. In this review, the healing and preventive effects of propolis are mentioned.

Proje Numarası

FDK-2019-6924

Kaynakça

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  • Maaroufi, H. 2020. LxxIxE-like Motif in Spike Protein of SARS-CoV-2 that is Known to Recruit the Host PP2A-B56 Phosphatase Mimics Artepillin C, an Immunomodulator, of Brazilian Green Propolis. Biorewiev. https://doi.org/10.1101/2020.04.01.020941
  • Mehmetoğlu, S. 2019. Propolis katkılı dondurmaların depolama süresince fizikokimyasal yapısının incelenmesi. Fen Bilimleri Enstitüsü, Yüksek Lisans Tezi, 75s. Ordu.
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  • Mojarab, S., Shahbazzadeh, D., Moghbeli, M., Eshraghi, Y., Bagheri, KP., Rahimi, Savoji, MA., Mahdavi, M. 2020. Immune responses to HIV-1 polytope vaccine candidate formulated in aqueous and alcoholic extracts of Propolis: Comparable immune responses to Alum and Freund adjuvants. Microbial Pathogenesis, 140, 103932. https://doi.org/10.1016/j.micpath.2019.103932
  • Mollahaliloğlu, S., Uğurlu, FG., Kalaycı, M., Öztaş, D. 2015. Geleneksel ve tamamlayıcı tıp uygulamalarında yeni dönem. Ankara Medikal Journal,15(2), 102-105. https://doi.org/10.17098/amj.44789
  • Moreno, MA., Vallejo, AM., Ballester, AR., Zampini, C., Isla, MI., López-Rubio, A., Fabra, MJ. 2020. Antifungal edible coatings containing Argentinian propolis extract and their application in raspberries. Food Hydrocolloids, 105973. https://doi.org/10.1016/j.foodhyd.2020.105973
  • Naz, S., Imran, M., Rauf, A., Orhan, IE., Shariati, MA., Ul-Haq, I., Yasmin, I., Shahbaz, M., Qaisrani, TB., Shah, ZA., Plygun, S., Heydari, M. 2019. Chrysin: Pharmacological and therapeutic properties. Life Sciences, 235, 116797. https://doi.org/10.1016/j.lfs.2019.116797
  • Olegario, LS., Andrade, JKS., Andrade, GRS., Denadal, M., Cavalcanti, RL., Silva, MAAP., Narain, N. 2019. Chemical characterization of four brazilian brown propolis: an insight in tracking of its geographical location of production and quality control. Food Research International, 123, 481-502. https://doi.org/10.1016/j.foodres.2019.04.004
  • Onur, E, Nalbantsoy, A., Kışla, D. 2018. İmmünoterapi ve propolisin kanser immünoterapisinde kullanım potansiyeli. Food and Health, 4(4), 231-246. https://doi.org/10.3153/FH18023
  • Orsolic, N., Jurcevic, IL., Dikic, D., Rogic, DD., Odeh, D., Balta, V., Junakovic, EP., Terzic, S., Jutric, D. 2019. Effects of propolis on diet-induced hyperlipidemia and atherogenic indices in mice. Antioxidants, 8(6), 156. https://doi.org/10.3390/antiox8060156
  • Padmavathi, R., Senthilnathan, P., Sakthisekaran, D. 2006. Therapeutic effect of propolis and propolis and paclitaxel on hepatic phase I and II enzymes and marker enzymes in Dimethylbenz(a)anthracene-Induced breast cancer in female rats. Comperative Biochemistry and Psysiology, 143, 349-354. https://doi.org/10.1016/j.cbpc.2006.03.009
  • Pahlavani, N., Sedaghat, A., Moghaddam, AB., Shabnam, S., Kiapey, M., Navashenaq, JG., Jarahi, L., Reazvani, R., Norouzy, A., Nematy, M., Safarian, M., Ghayour-Mobarhan, M. 2019. Effect of propolis and melatonin on oxidative stress, ınflammation, and clinical status in patients with primary sepsis: study protocol and review on previous studies. Clinical Nutrition ESPEN, 33, 125-131. https://doi.org/10.1016/j.clnesp.2019.06.007
  • Palaz, MN., Akçay, E., 2020. The impact of propolis factor caffeic acid phenethyl-ester on the cerebral vasospasm and early brain damage in the experimental induced subarachnoid herrhage on rats. World Neurosurgery, 138, 736-742. https://doi.org/10.1016/j.wneu.2020.03.058
  • Patel, S. 2016. Emerging adjuvant therapy for cancer: Propolis and its constituents. Journal of Dietary Supplements, 13(3), 245-268. https://doi.org/10.3109/19390211.2015.1008614
  • Pineros, AR., Lima, MHF., Rodrigues, T., Gembre, AF., Bertolini, TB., Fonseca, MD., Bernetta, AA., Ramalho LNZ., Cunha, FQ., Hori, JI., Bonato, VLD. 2020. Green propolis increases myeloid suppressor cells and CD4+ Foxp3+ cells and reduces Th2 inflammation in the lungs after allergen exposure. Journal of Ethnopharmacology, 252, 112496. https://doi.org/10.1016/j.jep.2019.112496
  • Popova, M., Giannopoulou, E., Skalicka-Wo´zniak, K., Graikou, K., Widelski, J., Bankova, V., Kalofonos, H., Sivolapenko, G., Gawe-Beben, K, Antosiewicz, B., Chinou, I. 2017. Characterization and biological evaluation of propolis from Poland. Molecules, 22, 1159. https://doi.org/10.3390/molecules22071159
  • Popova, M., Silici, S., Kaftanoğlu, O., Bankova, V. 2005. Antibacterial activity of Turkish propolis and its qualitative and quantitative chemical composition. Phytomedicine, 12, 221-228. https://doi:10.1016/j.phymed.2003.09.007
  • Putra, RA., Prasetyo, DH., Pesik, RN. 2015. The effect of propolis’ ethanolic extract on serum malondialdehyde level of mice Balb/c induced by cigarette smoke. Nexus Biomedika, 4(1).
  • Romeo, M., Freire, J., Pastene, E., Garcia, A., Aranda, M., Gonzales, C. 2019. Propolis phyphenolic compounds affect the viability and structure of Helicobacter pylori in vitro. Revista Brasilerira de Farmacognosia. 29(3), 325-332. https://doi.org/10.1016/j.bjp.2019.03.002
  • Santos, DA., Munari, FM., Silva Frozza, CO., Moura, S., Barcellos, T., Henriques, JAP., Roesch-Ely, M. 2019. Brazilian red propolis extracts: study of chemical composition by ESI-MS/MS(ESI+) and cytotoxic profiles aganist colon cancer cell lines. Biotechnology Research and Innovation, 3, 120-130. https://doi.org/10.1016/j.biori.2019.02.001
  • Seçilmiş Y., Silici, S. 2020. Bee product efficacy in children with upper respiratory tract infection. The Turkish Journal of Pediatrics, 62, 634-640. https://doi.org/10.24953/turkjped.2020.04.013
  • Seven, PT., Baykalır, BG., Ak, TP., Seven, İ., Başak, N., Yaman, M. 2018. The protective effects of propolis aand flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissues aganist excess copper in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 65, 395-406.
  • Sforcin, JM. 2016. Biological propoerties and therapeutic applications of propolis. Phytotherapy Research, 30, 894-905. https://doi.org/10.1002/ptr.5605
  • Silici, S., Güçlü, BK. 2018. Yumurtacı tavuk rasyonlarına propolis ve kafeik asit ilavesinin performans, yumurta kalitesi ve serum değişkenleri üzerine etkileri. Sağlık Bilimleri Dergisi, 27(3), 221-227.
  • Silva Frozza, CO., Santos, DA., Rufatto, LC., Minetto, L., Scariot, FJ., Echeverrigaray, S., Pich, CT., Moura, S., Padilha, FF., Borsuk, S., Savegnago, L., Collares, T., Seixas, FK., Dellagostin, O., Roesch-Ely, M., Henriques, JAP. 2017. Antitumor activity of brazilian red propolis fractions hep-2 cancer cell line. Biomedicine and Pharmacotherapy, 91, 951-963. https://doi.org/10.1016/j.biopha.2017.05.027
  • Spinelli, S., Conte, A., Lecce, L., Incoronato, L., Del Nobile, MA. 2015. Microencapsulated propolis to enhance the antioxidant properties of fresh fish burgers. Journal of Food Process Engineering, 38(6), 527-535. https://doi.org/10.1111/jfpe.12183
  • Sun, G., Qiu, Z., Wang, W., Sui, X., Sui, D., 2016. Flavonoids extraction from propolis attenuates pathological cardiac hypertrophy through PI3K//AKT signaling pathway. Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2016/6281376
  • Sun, LP., Xu, X., Hwang, HH., Wang, X., Su, KY., Chen, YLS. 2016. Dichromethane extracts of propolis protect cell from oxygen-glucose deprivation-induced oxidative stress via reducing apoptosis. Food and Nutrition Research, 60(1), 1-10. https://doi.org/10.3402/fnr.v60.30081
  • Sung, SH., Choi, GH., Lee, NW., Shin, BC 2017. External use of propolis oral, skin, and genital diseases: a systematic review and meta-analysis. Evidence-Based Complementary and Alternative Medicine., 2017, 8025752. https://doi.org/10.1155/2017/8025752
  • Tacconelli, E., Magrini, N., Singh, N. 2017. Global priority list of antibiotic-resistant bacteria. World Health Organization, Genece, 7s.
  • Talaş, ZS., Özdemir, İ., Çiftçi, O., Çakır, O., Gülhan, MF., Paşaoğlu, OM. 2014. Role of propolis on biochemical parameters in kidney and heart tissues against l-NAME induced oxidative injury in rats. Clinical and Experimental Hypertension. 36 (7), 492-496. https://doi.org/10.3109/10641963.2013.863322
  • Usman, ZU., Bakar, ABA., Mohamed, M. 2016. Phytochemical screening and comparison of antioxidant activity of water and ethanol extract propolis from Malaysia. International Journal of Pharmacy and Pharmaceutical Sciences, 8(5), 413-415.
  • Vagish Kumar, LS. 2014. Propolis in Dentisry and oral cancer management. North American Journal of Medical Science. 6(6), 250-259. https://doi.org/10.4103/1947-2714.134369
  • Vukovic, NL., Obradovic, AD., Vukic, MD., Jovanovic, D. 2018. Cytotoxic proapoptic and antioxidative potential of flavonoids isolated from propolis aganist colon (HTC-116) and breast (MDA-MB-231) cancer cell lines. Food Research International. 106, 71-80. https://doi.org/10.1016/j.foodres.2017.12.056
  • Walgrave, SE., Warshaw, EM., Glesne, LA. 2005. Allergic contact dermatitis from propolis. Dermatitis, 16 (4), 209-215.
  • Wu, JJ., Shen, CT., Jong, TT., Young, Chiu-Chung, Y., Yang, HL., Hsu, SL., Chang, CM., Shiesh, CJ. 2009. Supercritical carbon dioxide anti-solvent process for purification of micronized propolis particules and associated anti-cancer activity. Seperation and Purification Technology, 70, 190-198. https://doi.org/10.1016/j.seppur.2009.09.015
  • Yang, W., Wu, Z., Huang, ZY., Miao, X. 2017. Preservation of orange juice using propolis. Journal of Food Science and Technology -Mysore- 54(11),1-9. https://doi.org/10.1007/s13197-017-2754-x
  • Yılmaz, S., Kaya, E. 2018. Ratlarda siklofosfamid ile oluşturulmuş hemorajik sistitte propolis ve enginarın koruyucu etkileri. Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi. 32(2), 93-98
  • Yücel, B., Topal, E., Akçiçek, E., Köseoğlu, M. 2014. Propolisin insan sağlığına etkisi. Anadolu Journal of Agean Agriculture Reserarch Institute, 24(2), 41-49.
  • Zabaiou, N., Fouache, A., Trousson, A., Baron, S., Zellagui, A., Lahouel, M., Lobaccaro, JMA. 2017. Biological propoerties of propolis extrats: something new from an ancient product. Chemistry and Physics of Lipids, 207, 214-222. https://doi.org/10.1016/j.chemphyslip.2017.04.005
Toplam 122 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Gıda Mühendisliği
Bölüm Derlemeler
Yazarlar

Sultan Acun 0000-0003-1954-6102

Hülya Gül 0000-0002-6791-817X

Proje Numarası FDK-2019-6924
Yayımlanma Tarihi 9 Kasım 2020
Kabul Tarihi 15 Eylül 2020
Yayımlandığı Sayı Yıl 2020 Cilt: 20 Sayı: 2

Kaynak Göster

Vancouver Acun S, Gül H. FONKSİYONEL BİR ÜRÜN OLAN PROPOLİSİN SAĞLIK ÜZERİNE ETKİSİ. U.Arı D.-U.Bee J. 2020;20(2):189-208.

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