Changes in cardiac markers in a calf died of foot and mouth disease

Year 2022, Volume: 7 Issue: 3, 391 - 394, 31.12.2022

Cemalettin Ayvazoğlu , Erhan Gökçe , Hidayet Metin Erdoğan

https://doi.org/10.31797/vetbio.1107357

Abstract

This report disclosed changes in cardiac troponin expression during myocardial degeneration in a calf with foot and mouth disease (FMD). The case presented was a 7-day-old calf milk fed by its mother which diagnosed as having FMD (O-type) by Ministry of Agriculture and Forestry Şap (Foot and Mouth Disease) Institute. The calf suffered from myocarditis due to suckling FMD infected dam. Blood sample was taken from the jugular vein of calf. Serum cTn-T, cTn-I, CK-MB, LDH, AST and ALT levels were measured using commercial kits. cTn-T, cTn-I, CK-MB, LDH, AST and ALT levels were determined as 1.00 ng/mL, 26.68 ng/mL, 262 U/L, 4503 U/L, 56.6 U/L, 55.3 U/L, respectively and these values were higher than those of healthy calf. It is thought that the use of cardiac troponins (cTn-I, cTn-T) for the diagnosis of the disease will give accurate and rapid results.

Keywords

Calf, CK-MB, cTn-I, cTn-T, FMD

Thanks

The authors would like to thank and acknowledge the Ministry of Agriculture and Forestry Şap (Foot and Mouth Disease) Institute.

Şap hastalığından ölen bir buzağıda kardiyak belirteçlerdeki değişiklikler

Abstract

Bu rapor Şap hastalığı olan bir buzağıda miyokardiyal dejenerasyon sırasında kardiyak troponin ekspresyonundaki değişiklikleri belirlemek için yapılmıştır. Sunulan olgu, Tarım ve Orman Bakanlığı Şap Enstitüsü tarafından Şap (O-tipi) tanısı konan annesi tarafından beslenen 7 günlük bir buzağı üzerinde gerçekleştirildi. Raporda kullanılan buzağı anneden emdiği kolostrum nedeniyle miyokarditis’e yakalanmıştır. Hastanın V. Jugularis’den alınan kan örneği ile serum cTn-T, cTn-I, CK-MB, LDH, AST ve ALT seviyeleri ticari kitler kullanılarak ölçüldü. cTn-T, cTn-I, CK-MB, LDH, AST ve ALT seviyeleri sırasıyla 1.00 ng/mL, 26.68 ng/mL, 262 U/L, 4503 U/L, 56.6 U/L, 55.3 U/L tespit edildi ve sağlıklı buzağılara göre bu değerler yüksek bulundu. Kardiyak troponinlerin (cTn-I, cTn-T) hastalığın tanısında kullanılmasının doğru ve hızlı sonuç vereceği düşünülmektedir.

Keywords

Buzağı, CK-MB, cTn-T, cTn-I, Şap Hastalığı

References

• Akın, H., Güneş, V., & Bekdik, İ. K. (2015). Practice Cardiac Troponin I Kit Expressions and Concentrations of Cardiac Troponin I in Beef Cattle with Foot and Mouth Disease. Journal of Faculty of Veterinary Medicine, Erciyes University/Erciyes Üniversitesi Veteriner Fakültesi Dergisi, 12(3), 163-170.
• Alexandersen, S., Quan, M., Murphy, C., Knight, J., & Zhang, Z. (2003). Studies of quantitative parameters of virus excretion and transmission in pigs and cattle experimentally infected with foot-and-mouth disease virus. Journal of comparative pathology, 129(4), 268-282.
• AlSaad, K. M., Al-Autaish, H. N., & Ahmed, J. A. (2020). Evaluation of cardiac enzymes and acute phase response as biomarkers for rapid diagnosis of myocarditis in calves with FMD. Iraqi Journal of Veterinary Sciences, 34(1), 31-37.
• Aly, M., Nayel, M., Salama, A., Ghazy, E., & Elshahawy, I. (2020). Cardiac troponin I as a cardiac biomarker has prognostic and predictive value for poor survival in Egyptian buffalo calves with foot-and-mouth disease. Veterinary World, 13(5), 890-895.
• Aydogdu, U., Yildiz, R., Guzelbektes, H., Coskun, A., & Sen, I. (2016). Cardiac biomarkers in premature calves with respiratory distress syndrome. Acta Veterinaria Hungarica, 64(1), 38-46.
• Barnett, P. V., & Cox, S. J. (1999). The role of small ruminants in the epidemiology and transmission of foot-and-mouth disease. The Veterinary Journal, 158(1), 6-13.
• Bayraktar, B. (2014). Investigation of the effectiveness of cardiac troponins in the determination of myocardial damage in lambs and kids. PhD Thesis. Adnan Menderes University, Institute of Health Science.
• Cha, C. N., Park, E. K., Yoo, C. Y., Kim, S., Yun, Y. W., & Lee, H. J. (2017). Blood parameter changes in Korean traditional calves and pigs after foot-and-mouth disease vaccination. Korean Journal of Veterinary Research, 57(1), 43-45.
• Çiftçi, M. K., & İnanç, M. (2017). Şap Hastalığının Miyokardiyal Formundan Ölen İki Kuzuda Kalp ve Dilde Gözlenen Patolojik Bulgular. Bahri Dağdaş Hayvancılık Araştırma Dergisi, 6(2), 15-22.
• Dawood, A. A., & Alsaad, K. M. (2018). Clinical and diagnostic studies of myocarditis result from FMD in lambs. J. Agric. Vet. Sci, 11(7), 01-10.
• El-Khuffash, A. F., & Molloy, E. J. (2008). Serum troponin in neonatal intensive care. Neonatology, 94(1), 1-7.
• Gulbahar, M. Y., Davis, W. C., Guvenc, T., Yarim, M., Parlak, U., & Kabak, Y. B. (2007). Myocarditis associated with foot-and-mouth disease virus type O in lambs. Veterinary pathology, 44(5), 589-599.
• Hughes, G. J., Mioulet, V., Haydon, D. T., Kitching, R. P., Donaldson, A. I., & Woolhouse, M. E. (2002). Serial passage of foot-and-mouth disease virus in sheep reveals declining levels of viraemia over time. Journal of General Virology, 83(8), 1907-1914.
• Kitching, P., Hammond, J., Jeggo, M., Charleston, B., Paton, D., Rodriguez, L., & Heckert, R. (2007). Global FMD control—is it an option?. Vaccine, 25(30), 5660-5664.
• Lubroth, J. (2002). Foot-and-mouth disease: a review for the practitioner. Veterinary Clinics: Food Animal Practice, 18(3), 475-499.
• Ooi, D. S., Isotalo, P. A., & Veinot, J. P. (2000). Correlation of antemortem serum creatine kinase, creatine kinase-MB, troponin I, and troponin T with cardiac pathology. Clinical chemistry, 46(3), 338-344.
• Rajappa, M., & Sharma, A. (2005). Biomarkers of cardiac injury: an update. Angiology, 56(6), 677-691.
• Salim, S. A. S., Talb, O. Q., Saad, M. S., & Yousif, A. S. (2019). Clinico-pathological and biochemical aspects of foot and mouth disease in calves. Adv. Anim. Vet. Sci, 7(10), 835-843.
• Sobrino, F., Palma, E. L., Beck, E., Davila, M., De La Torre, J. C., Negro, P., Villanueva, N., Ortín, J., & Domingo, E. (1986). Fixation of mutations in the viral genome during an outbreak of foot-and-mouth disease: heterogeneity and rate variations. Gene, 50(1-3), 149-159.
• Tunca, R., Erdoğan, H. M., Sözmen, M., Çitil, M., Devrim, A. K., Erginsoy, S., & Uzlu, E. (2009). Evaluation of cardiac troponin I and inducible nitric oxide synthase expressions in lambs with white muscle disease. Turkish Journal of Veterinary and Animal Sciences, 33(1), 53-59.
• Tunca, R., Sozmen, M., Erdogan, H., Citil, M., Uzlu, E., Ozen, H., & Gokçe, E. (2008). Determination of cardiac troponin I in the blood and heart of calves with foot-and-mouth disease. Journal of veterinary diagnostic investigation, 20(5), 598-605.
• Undhad, V. V., Fefar, D. T., Jivani, B. M., Gupta, H., Ghodasara, D. J., Joshi, B. P., & Prajapati, K. S. (2012). Cardiac troponin: an emerging cardiac biomarker in animal health. Vet World, 5(8), 508-511.
• Windsor, M. A., Carr, B. V., Bankowski, B., Gibson, D., Reid, E., Hamblin, P., ... & Charleston, B. (2011). Cattle remain immunocompetent during the acute phase of foot-and-mouth disease virus infection. Veterinary research, 42(1), 1-11.