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PROBİYOTİK VE PREBİYOTİK TÜKETİMİNİN LAKTOZ İNTOLERANSI ÜZERİNE ETKİLERİ

Yıl 2020, , 380 - 389, 15.01.2020
https://doi.org/10.15237/gida.GD20016

Öz

Dünya genelinde yüksek oranda görülen laktaz yetersizliğinin tedavi edilmesi veya sebep olduğu olumsuz etkilerin azaltılması üzerine uzun yıllardır çok sayıda çalışma yapılmıştır. Süt tüketiminin mecburen azaltılmasına neden olan laktaz yetersizliğinin temelde genetik faktörlere dayanması, bu rahatsızlığın önlenmesine engel olmaktadır. Ancak önlenemese de süt tüketimine imkan tanıyacak kadar ortaya çıkan rahatsızlıkların kontrol altına alınması mümkündür. Bu nedenle daha çok bu etkileri azaltmaya yönelik alternatif çözümler aranmaktadır. Son yıllarda yapılan araştırmalar, bu amaçla probiyotik ve prebiyotik tüketiminin laktoz intoleransına sahip kişilerde laktaz yetersizliğine bağlı olarak görülen etkileri azalttığını göstermiştir. Bu çalışma kapsamında laktoz intoleransı üzerine probiyotik ve prebiyotik kullanımının etkileri üzerine yapılan araştırmalar incelenmiştir.

Kaynakça

  • Almeida, C.C., Lorena, S.L.S., Pavan, C.R., Akasaka, H.M.I., Mesquita, M.A. (2012). Beneficial effects of long-term consumption of a probiotic combination of Lactobacillus casei shirota and Bifidobacterium breve yakult may persist after suspension of therapy in lactose-intolerant patients. Nutrition in Clinical Practice, 27: 247–251.
  • Amiri, M., Diekmann, L., von Köckritz-Blickwede, M., Naim, H.Y. (2015). The Diverse Forms of Lactose Intolerance and the Putative Linkage to Several Cancers. Nutrients, 7: 7209-7230, doi:10.3390/nu7095332
  • Arnold, J.W., Simpson, J.B., Roach, J., Bruno-Barcena, J.M., Azacarate-Peril, M.A. (2018). Prebiotics for Lactose Intolerance: Variability in Galacto-Oligosaccharide Utilization by Intestinal Lactobacillus rhamnosus. Nutrients, 10: 1517. doi:10.3390/nu10101517.
  • Azcarate-Peril, M.A., Ritter, A.J., Savaiano, D., Monteagudo-Mera, A., Anderson, C., Magness, S.T., Klaenhammer, T.R. (2017). Impact of short-chain galactooligosaccharides on the gut microbiome of lactose-intolerant individuals. Proceedings of the National Academy of Sciences, 114, E367-E375.
  • Bakken, T., Braaten, T., Olsen, A., Hjartåker, A., Lund, E., Skeie, G. (2018). Milk and risk of colorectal, colon and rectal cancer in the Norwegian Women and Cancer (NOWAC) Cohort Study. British Journal of Nutrition, 119: 1274-1285.
  • Barrubes, L., Babio N., Mena-Sanchez G., Toledo E., Ramirez-Sabio J.B., Estruch, R., Ros, E., Fito, M., Aros, F., Fiol, M., Santos-Lozana, J., Serra-Majem, L., Pinto, X., Martınez-Gonzalez, M. A., Sorli, J. V., Basora, J., Salas-Salvado, J. (2018). Dairy product consumption and risk of colorectal cancer in an older Mediterranean population at high cardiovascular risk. International Journal of Cancer, 143: 1356–1366.
  • Bayhan, A. ve Yentür G. (1993). Laktoz İntoleransı. Gıda, 18(6): 385-388.
  • Bayless, T. M., Brown, E., Paige, D. M. (2017). Lactase Non-persistence and Lactose Intolerance. Current Gastroenterology Reports, 19:23. DOI:10.1007/s11894-017-0558-9.
  • Cano‐Contreras, A.D., Pérez y López, N.J., Minero‐Alfaro I., Medina‐López; V.M., Reyes‐Huerta. J. U. (2019). Efficacy of probiotic I3.1 symptomatic improvement in patients with lactose intolerance. Abstracts of the 18th American Neurogastroenterology and Motility Society Annual Scientific Meeting, 16-18 August, Chicago, Illinois, USA.
  • Corgneau, M.M., Scher, J., Ritie-Pertusa, L., Le D.T.L., Petit, J., Nikolova, Y., Banon, S., Gaiani, C. (2017). Recent advances on lactose intolerance: Tolerance thresholds and currently available answers, Critical Reviews in Food Science and Nutrition, 57:15, 3344-3356, DOI:10.1080/10408398.2015.1123671.
  • Costanzo, D. M., Canani, R. B. (2018). Lactose intolerance: Common misunderstandings. Annals of Nutrition and Metabolism, 73 (suppl 4):30-37.
  • Däbritz, J., Mühlbauer, M., Domagk, D., Voos, N., Henneböhl, G., Siemer, M.L., Foell, D. (2014). Significance of hydrogen breath tests in children with suspected carbohydrate malabsorption. BMC Pediatrics.14. doi: 10.1186/1471-2431-14-59.
  • Demirgül, F. ve Demirgül R. (2019). Laktoz intoleransın prevalansı, teşhisi ve laktozsuz beslenme tavsiyeleri. Food and Health, 5(4), 281-290. https://doi.org/10.3153/FH19028.
  • Dhama, K., Latheef, S. K. and Munjal A. K. (2016). Probiotics in curing allergic and inflammatory conditions – Research progress and futuristic vision. Recent Patents on Inflammation & Allergy Drug Discovery, 10 (1):21-33.
  • Domínguez-Jiménez, J.L., Fernández-Suárez, A. (2017). Diagnosis of lactose intolerance. Medicina Clínica, 148(6):262-264.
  • Fassio, F., Facioni, M. S., Guagnini, F. (2018). Lactose Maldigestion, Malabsorption, and Intolerance: A Comprehensive Review with a Focus on Current Management and Future Perspectives. Nutrients, 10: 1599; doi:10.3390/nu10111599.
  • Forsgård, R. A. (2019). Lactose digestion in humans: intestinal lactase appears to be constitutive whereas the colonic microbiome is adaptable. The American Journal of Clinical Nutrition, 110:273-279.
  • Fox, P.F., Uniacke-Lowe, T., McSweeney, P.L.H. and O’Mahony, J.A.M. (2015). Lactose. In: Dairy Chemistry and Biochemistry, 21–68. Springer International Publishing, Cham.
  • Ganesan, K., Chung, S. K., Vanamala, J., Xu, B. (2018). Causal Relationship between Diet-Induced Gut Microbiota Changes and Diabetes: A Novel Strategy to Transplant Faecalibacterium prausnitzii in Preventing Diabetes. International Journal of Molecular Sciences, 19: 3720. doi:10.3390/ijms19123720
  • Gingold-Belfer, R., Levy, S., Layfer, O., Pakanaev, L., Niv, Y., Dickman, R., Parets, T. T. (2019). Use of a Novel Probiotic Formulation to Alleviate Lactose Intolerance Symptoms—a Pilot Study. Probiotics and Antimicrobial Proteins, Jan 7. https://doi.org/10.1007/s12602-018-9507-7. Hajare, S.T., Bekele, G. (2017). Effect of probiotic strain Lactobacillus acidophilus (LBKV-3) on fecal residual lactase activity in undernourished children below 10 years. Journal of Immunoassay and Immunochemistry, 38(6): 620-628.
  • Harvey, L., Ludwig, T., Hou, A. Q., Hock, Q. S., Tan, M. L. N., Osatakul, S., Bindels, J., Muhardi, L. (2018). Prevalence, cause and diagnosis of lactose intolerance in children aged 1–5 years: a systematic review of 1995–2015 literature. Asia Pacific Journal of Clinical Nutrition, 27(1):29-46.
  • He, T., Priebe, M.G., Harmsen, H.J.M., Stellaard, F., Sun, X., Welling, G.W., Vonk, R.J. (2006). Colonic fermentation may play a role in lactose intolerance in humans. The Journal of Nutrition, 136(1): 58-63.
  • He, T., Priebe, M. G., Zhong, Y., Huang, C., Harmsen, H. J. M., Raangs, G. C., Antoine, J. M., Welling, G. W., Vonk, R. J. (2008). Effects of yogurt and bifidobacteria supplementation on the colonic microbiota in lactose-intolerant subjects. Journal of Applied Microbiology, 104: 595–604. doi:10.1111/j.1365-2672.2007.03579.x
  • Hegar, B., Widodo A. (2015). Lactose intolerance in Indonesian children. Asia Pacific Journal of Clinical Nutrition. 215, 24(Suppl 1):S31-40. doi: 10.6133/apjcn.2015.24.s1.06. Kim, J.W. (2017). Lactose intolerance and colorectal cancer. Annals of Coloproctology, 33(5):157-158.
  • Kleniewska, P., Hoffmann, A., Pniewska, E., Pawliczak, R. (2016). The Influence of Probiotic Lactobacillus casei in combination with prebiotic ınulin on the antioxidant capacity of human plasma. Oxidative Medicine and Cellular Longevity, 2016:1340903.
  • Latorre, G., Besa, P., Parodi, C.G., Ferrer, V., Azocar, L., Quirola, M. and Chianale, J. (2014). Prevalence of lactose intolerance in Chile: a double-blind placebo study. Digestion, 90(1): 18-26.
  • Liu, F., Li, P., Chen, M., Luo, Y., Prabhakar, M., Zheng, H., He, Y., Qi, Q., Long, H., Zhang, Y., Sheng, H., Zhou, H. (2017). Fructooligosaccharide (FOS) and galactooligosaccharide (GOS) increase Bifidobacterium but reduce butyrate producing bacteria with adverse glycemic metabolism in healthy young population. Scientific Reports, 7: 11789.
  • Ma, J., Giovannucci, E., Pollak, M., Chan, J. M., Gaziano, J. M., Willett, W., Stampfer, M. J. (2001). Milk intake, circulating levels of insulin-like growth factor-1, and risk of colorectal cancer in men. Journal of the National Cancer Institute, 93: 1330-1336.
  • Mahboubi, M., Kazempour, N. (2016). The effects of inulin on characteristics of Lactobacillus paracasei TD3 (IBRC-M 10784) as probiotic bacteria in vitro. Archives of Iranian Medicine, 19(2): 92-95.
  • Melini, F., Melini, V., Luziatelli, F., Ficca, A. G., Ruzzi, M. (2019). Health-promoting components in fermented foods: An up-to-date systematic review. Nutrients 11: 1189. Metin, M. (2005). Süt Teknolojisi Sütün bileşimi ve işlenmesi. Ege Üniversitesi Basımevi, İzmir, 802 s. Moens, F., Weckx, S., Vuyst, L. D. (2016). Bifidobacterial inulin-type fructan degradation capacity determines cross-feeding interactions between bifidobacteria and Faecalibacterium prausnitzii. International Journal of Food Microbiology, 231: 76-85.
  • Minale, P., Hiller, J., Kramer, M. F., Heath, M., Justicia, J. L. (2019). Symbiotics as a new perspective in the treatment of lactose intolerance. Annals of Nutrition and Metabolism, 74(suppl 1):1-31.
  • Muñoz-Tamayo, R., Laroche, B., Walter, E., Doré, J., Duncan, S.H., Flint, H.J., Leclerc, M. (2011). Kinetic Modelling of lactate utilization and butyrate production by key human colonic bacterial species. FEMS Microbiology Ecology, 76(3):615-624.
  • Mustapha, A., Jiang, T., Savaiano, D.A. (1997). Improvement of lactose digestion by humans following ingestion of unfermented acidophilus milk: influence of bile sensitivity, lactose transport, and acid tolerance of Lactobacillus acidophilus. Journal of Dairy Science, 80:1537-1545.
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THE EFFECTS OF PROBIOTIC AND PREBIOTIC CONSUMPTION ON LACTOSE INTOLERANCE

Yıl 2020, , 380 - 389, 15.01.2020
https://doi.org/10.15237/gida.GD20016

Öz

For many years, different studies have been conducted on the treatment or reducing the harmful effects of lactase deficiency, which is prevailing all around the world. Lactase deficiency, which causes to reduce milk consumption, is mainly based on genetic factors, and they inhibit the prevention of this disease. However, even if it cannot be prevented, it is possible to control the disorders that occur to allow milk consumption. Therefore, alternative methods are being sought to reduce these effects. Recent studies have shown that probiotics and prebiotic consumption reduces the impacts of lactase deficiency in people with lactose intolerance. This paper reviews the studies on the effects of probiotic and prebiotic use on lactose intolerance.

Kaynakça

  • Almeida, C.C., Lorena, S.L.S., Pavan, C.R., Akasaka, H.M.I., Mesquita, M.A. (2012). Beneficial effects of long-term consumption of a probiotic combination of Lactobacillus casei shirota and Bifidobacterium breve yakult may persist after suspension of therapy in lactose-intolerant patients. Nutrition in Clinical Practice, 27: 247–251.
  • Amiri, M., Diekmann, L., von Köckritz-Blickwede, M., Naim, H.Y. (2015). The Diverse Forms of Lactose Intolerance and the Putative Linkage to Several Cancers. Nutrients, 7: 7209-7230, doi:10.3390/nu7095332
  • Arnold, J.W., Simpson, J.B., Roach, J., Bruno-Barcena, J.M., Azacarate-Peril, M.A. (2018). Prebiotics for Lactose Intolerance: Variability in Galacto-Oligosaccharide Utilization by Intestinal Lactobacillus rhamnosus. Nutrients, 10: 1517. doi:10.3390/nu10101517.
  • Azcarate-Peril, M.A., Ritter, A.J., Savaiano, D., Monteagudo-Mera, A., Anderson, C., Magness, S.T., Klaenhammer, T.R. (2017). Impact of short-chain galactooligosaccharides on the gut microbiome of lactose-intolerant individuals. Proceedings of the National Academy of Sciences, 114, E367-E375.
  • Bakken, T., Braaten, T., Olsen, A., Hjartåker, A., Lund, E., Skeie, G. (2018). Milk and risk of colorectal, colon and rectal cancer in the Norwegian Women and Cancer (NOWAC) Cohort Study. British Journal of Nutrition, 119: 1274-1285.
  • Barrubes, L., Babio N., Mena-Sanchez G., Toledo E., Ramirez-Sabio J.B., Estruch, R., Ros, E., Fito, M., Aros, F., Fiol, M., Santos-Lozana, J., Serra-Majem, L., Pinto, X., Martınez-Gonzalez, M. A., Sorli, J. V., Basora, J., Salas-Salvado, J. (2018). Dairy product consumption and risk of colorectal cancer in an older Mediterranean population at high cardiovascular risk. International Journal of Cancer, 143: 1356–1366.
  • Bayhan, A. ve Yentür G. (1993). Laktoz İntoleransı. Gıda, 18(6): 385-388.
  • Bayless, T. M., Brown, E., Paige, D. M. (2017). Lactase Non-persistence and Lactose Intolerance. Current Gastroenterology Reports, 19:23. DOI:10.1007/s11894-017-0558-9.
  • Cano‐Contreras, A.D., Pérez y López, N.J., Minero‐Alfaro I., Medina‐López; V.M., Reyes‐Huerta. J. U. (2019). Efficacy of probiotic I3.1 symptomatic improvement in patients with lactose intolerance. Abstracts of the 18th American Neurogastroenterology and Motility Society Annual Scientific Meeting, 16-18 August, Chicago, Illinois, USA.
  • Corgneau, M.M., Scher, J., Ritie-Pertusa, L., Le D.T.L., Petit, J., Nikolova, Y., Banon, S., Gaiani, C. (2017). Recent advances on lactose intolerance: Tolerance thresholds and currently available answers, Critical Reviews in Food Science and Nutrition, 57:15, 3344-3356, DOI:10.1080/10408398.2015.1123671.
  • Costanzo, D. M., Canani, R. B. (2018). Lactose intolerance: Common misunderstandings. Annals of Nutrition and Metabolism, 73 (suppl 4):30-37.
  • Däbritz, J., Mühlbauer, M., Domagk, D., Voos, N., Henneböhl, G., Siemer, M.L., Foell, D. (2014). Significance of hydrogen breath tests in children with suspected carbohydrate malabsorption. BMC Pediatrics.14. doi: 10.1186/1471-2431-14-59.
  • Demirgül, F. ve Demirgül R. (2019). Laktoz intoleransın prevalansı, teşhisi ve laktozsuz beslenme tavsiyeleri. Food and Health, 5(4), 281-290. https://doi.org/10.3153/FH19028.
  • Dhama, K., Latheef, S. K. and Munjal A. K. (2016). Probiotics in curing allergic and inflammatory conditions – Research progress and futuristic vision. Recent Patents on Inflammation & Allergy Drug Discovery, 10 (1):21-33.
  • Domínguez-Jiménez, J.L., Fernández-Suárez, A. (2017). Diagnosis of lactose intolerance. Medicina Clínica, 148(6):262-264.
  • Fassio, F., Facioni, M. S., Guagnini, F. (2018). Lactose Maldigestion, Malabsorption, and Intolerance: A Comprehensive Review with a Focus on Current Management and Future Perspectives. Nutrients, 10: 1599; doi:10.3390/nu10111599.
  • Forsgård, R. A. (2019). Lactose digestion in humans: intestinal lactase appears to be constitutive whereas the colonic microbiome is adaptable. The American Journal of Clinical Nutrition, 110:273-279.
  • Fox, P.F., Uniacke-Lowe, T., McSweeney, P.L.H. and O’Mahony, J.A.M. (2015). Lactose. In: Dairy Chemistry and Biochemistry, 21–68. Springer International Publishing, Cham.
  • Ganesan, K., Chung, S. K., Vanamala, J., Xu, B. (2018). Causal Relationship between Diet-Induced Gut Microbiota Changes and Diabetes: A Novel Strategy to Transplant Faecalibacterium prausnitzii in Preventing Diabetes. International Journal of Molecular Sciences, 19: 3720. doi:10.3390/ijms19123720
  • Gingold-Belfer, R., Levy, S., Layfer, O., Pakanaev, L., Niv, Y., Dickman, R., Parets, T. T. (2019). Use of a Novel Probiotic Formulation to Alleviate Lactose Intolerance Symptoms—a Pilot Study. Probiotics and Antimicrobial Proteins, Jan 7. https://doi.org/10.1007/s12602-018-9507-7. Hajare, S.T., Bekele, G. (2017). Effect of probiotic strain Lactobacillus acidophilus (LBKV-3) on fecal residual lactase activity in undernourished children below 10 years. Journal of Immunoassay and Immunochemistry, 38(6): 620-628.
  • Harvey, L., Ludwig, T., Hou, A. Q., Hock, Q. S., Tan, M. L. N., Osatakul, S., Bindels, J., Muhardi, L. (2018). Prevalence, cause and diagnosis of lactose intolerance in children aged 1–5 years: a systematic review of 1995–2015 literature. Asia Pacific Journal of Clinical Nutrition, 27(1):29-46.
  • He, T., Priebe, M.G., Harmsen, H.J.M., Stellaard, F., Sun, X., Welling, G.W., Vonk, R.J. (2006). Colonic fermentation may play a role in lactose intolerance in humans. The Journal of Nutrition, 136(1): 58-63.
  • He, T., Priebe, M. G., Zhong, Y., Huang, C., Harmsen, H. J. M., Raangs, G. C., Antoine, J. M., Welling, G. W., Vonk, R. J. (2008). Effects of yogurt and bifidobacteria supplementation on the colonic microbiota in lactose-intolerant subjects. Journal of Applied Microbiology, 104: 595–604. doi:10.1111/j.1365-2672.2007.03579.x
  • Hegar, B., Widodo A. (2015). Lactose intolerance in Indonesian children. Asia Pacific Journal of Clinical Nutrition. 215, 24(Suppl 1):S31-40. doi: 10.6133/apjcn.2015.24.s1.06. Kim, J.W. (2017). Lactose intolerance and colorectal cancer. Annals of Coloproctology, 33(5):157-158.
  • Kleniewska, P., Hoffmann, A., Pniewska, E., Pawliczak, R. (2016). The Influence of Probiotic Lactobacillus casei in combination with prebiotic ınulin on the antioxidant capacity of human plasma. Oxidative Medicine and Cellular Longevity, 2016:1340903.
  • Latorre, G., Besa, P., Parodi, C.G., Ferrer, V., Azocar, L., Quirola, M. and Chianale, J. (2014). Prevalence of lactose intolerance in Chile: a double-blind placebo study. Digestion, 90(1): 18-26.
  • Liu, F., Li, P., Chen, M., Luo, Y., Prabhakar, M., Zheng, H., He, Y., Qi, Q., Long, H., Zhang, Y., Sheng, H., Zhou, H. (2017). Fructooligosaccharide (FOS) and galactooligosaccharide (GOS) increase Bifidobacterium but reduce butyrate producing bacteria with adverse glycemic metabolism in healthy young population. Scientific Reports, 7: 11789.
  • Ma, J., Giovannucci, E., Pollak, M., Chan, J. M., Gaziano, J. M., Willett, W., Stampfer, M. J. (2001). Milk intake, circulating levels of insulin-like growth factor-1, and risk of colorectal cancer in men. Journal of the National Cancer Institute, 93: 1330-1336.
  • Mahboubi, M., Kazempour, N. (2016). The effects of inulin on characteristics of Lactobacillus paracasei TD3 (IBRC-M 10784) as probiotic bacteria in vitro. Archives of Iranian Medicine, 19(2): 92-95.
  • Melini, F., Melini, V., Luziatelli, F., Ficca, A. G., Ruzzi, M. (2019). Health-promoting components in fermented foods: An up-to-date systematic review. Nutrients 11: 1189. Metin, M. (2005). Süt Teknolojisi Sütün bileşimi ve işlenmesi. Ege Üniversitesi Basımevi, İzmir, 802 s. Moens, F., Weckx, S., Vuyst, L. D. (2016). Bifidobacterial inulin-type fructan degradation capacity determines cross-feeding interactions between bifidobacteria and Faecalibacterium prausnitzii. International Journal of Food Microbiology, 231: 76-85.
  • Minale, P., Hiller, J., Kramer, M. F., Heath, M., Justicia, J. L. (2019). Symbiotics as a new perspective in the treatment of lactose intolerance. Annals of Nutrition and Metabolism, 74(suppl 1):1-31.
  • Muñoz-Tamayo, R., Laroche, B., Walter, E., Doré, J., Duncan, S.H., Flint, H.J., Leclerc, M. (2011). Kinetic Modelling of lactate utilization and butyrate production by key human colonic bacterial species. FEMS Microbiology Ecology, 76(3):615-624.
  • Mustapha, A., Jiang, T., Savaiano, D.A. (1997). Improvement of lactose digestion by humans following ingestion of unfermented acidophilus milk: influence of bile sensitivity, lactose transport, and acid tolerance of Lactobacillus acidophilus. Journal of Dairy Science, 80:1537-1545.
  • Noble, S., Rawlinson, F. and Byrne, A. (2002). Acquired lactose intolerance: A seldom considered cause of diarrhea in the palliative care setting. Journal of Pain and Symptom Management, 23: 449-508.
  • Oak, S. J. ve Jha, R. (2019) The effects of probiotics in lactose intolerance: A systematic review. Critical Reviews in Food Science and Nutrition, 59 (11): 1675-1683.
  • Ozturkoglu-Budak, S., Akal, H.C., Buran, İ., Yetişemiyen, A. (2019). Effect of inulin polymerization degree on various properties of synbiotic fermented milk including Lactobacillus acidophilus La-5 and Bifidobacterium animalis Bb-12. Journal of Dairy Science, 102(8): 6901-6913
  • Pakdaman, M.N., Udani, J.K., Molina, J.P., Shahani, M. (2016). The effects of the DDS-1 strain of lactobacillus on symptomatic relief for lactose intolerance: a randomized, double-blind, placebo-controlled, crossover clinical trial. Nutrition Journal, 15 (1):56.
  • Pawłowska, K., Umławska, W. and Iwanczak, B. (2015). Prevalence of lactose malabsorption and lactose intolerance in pediatric patients with selected gastrointestinal diseases. Advances in Clinical and Experimental Medicine, 24 (5): 863-871.
  • Perna, A., Intaglietta, I., Simonetti, A., Gambacorta, E. (2015). Donkey milk for manufacture of novel functional fermented beverages. Journal of Food Science, 80: 1352-1359.
  • Ritter, A.J., Chey, W.D., Foyt, H.L., Sandborn, W.J., Savaiano, D.A. (2018). Improvement of clinical symptoms of lactose intolerance with a novel prebiotic galacto-oligosaccharide, RP-G28. AGA Abstracts. 154(6-1):1047.
  • Roškar, I., Švigelj, K., Štempelj, M., Volfand, J., Štabuc, B., Malovrh, Š., Rogelj, I. (2017). Effects of a probiotic product containing Bifidobacterium animalis subsp. animalis IM386 and Lactobacillus plantarum MP2026 in lactose intolerant individuals: Randomized, placebo-controlled clinical trial. Journal of Functional Foods, 35: 1-8.
  • Santos, G. J., Rocha, R., Santana, G. O. (2019). Lactose intolerance: what is a correct management? Revista da Associação Médica Brasileira, 65(2):270-275.
  • Savaiano, D.A., Ritter, A.J., Klaenhammer, T.R., James, G.M., Longcore, A.T., Chandler, J.R., Walker, W.A., Foyt, H.L. (2013). Improving lactose digestion and symptoms of lactose intolerance with a novel galacto-oligosaccharide (RP-G28): A randomized, double-blind clinical trial. Nutrition Journal, 12:160.
  • Sharifi-Zahabi, E., Abdollahzad,, H., Nachvak,, S.M., Pasdar, Y., Bagheri, A., Sahargahi, B., Mahaki, B. (2018). Prevalence of lactose intolerance and its association with breakfast consumption in Iranian adolescents. Nutrition & Food Science, 49(1): 170-178.
  • Staudacher, H. (2015). Probiotics for lactose intolerance and irritable bowel syndrome. British Journal of Community Nursing, June/July: 12-14.
  • Swallow, D.M. (2003). Genetics of lactase persistence and lactose intolerance. Annual Review of Genetics, 37:197-219.
  • Szilagyi, A., Ishayek, N. (2018). Lactose Intolerance, Dairy Avoidance, and Treatment Options. Nutrients, 10: 1-30. doi:10.3390/nu10121994
  • Thongaram, T., Hoeflinger, J.L., Chow, J., Miller, M.J. (2017). Prebiotic galactooligosaccharide metabolism by probiotic lactobacilli and bifidobacteria. Journal of Agricultural and Food Chemistry, 65: 4184-4192.
  • Usai-Satta, P., Scarpa, M., Oppia, F., Cabras, F. (2012). Lactose malabsorption and intolerance: What should be the best clinical management? World Journal of Gastrointestinal Pharmacology and Therapeutics, 3(3): 29-33.
  • Ugidos-Rodríguez, S., Matallana-González, M.C., Sánchez-Mata, M.C. (2018). Lactose malabsorption and intolerance: a review. Food & Function, 9: 4056- 4068.
  • Uymaz, B. (2010). Probiyotikler ve Kullanım alanları. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi, 16 (1): 95-104.
  • Vitellio, P., Celano, G., Bonfrate, L., Gobbetti, M., Portincasa, P., Angelis, M.D. (2019). Effects of Bifidobacterium longum and Lactobacillus rhamnosus on gut microbiota in patients with lactose ıntolerance and persisting functional gastrointestinal symptoms: A randomised, double-blind, cross-over study. Nutrients, 11: 886. doi:10.3390/nu11040886.
  • Vonk, R.J., Reckman, G.A.R., Harmsen, H.J.M., Priebe, M.G. (2012). Probiotics and Lactose Intolerance. In: Probiotics, IntechOpen, doi: 10.5772/51424.
  • WCRFI/AICR (World Cancer Research Fund International/American Institute for Cancer Research). (2017). Continuous Update Project Report. Diet, Nutrition, Physical Activity and Colorectal Cancer. WCRF Network. London/Washington, DC.
  • Zheng, X., Chu, H., Cong, Y., Deng, Y., Long, Y., Zhu, Y. and Fox, M. (2015). Self-reported lactose intolerance in clinic patients with functional gastrointestinal symptoms: prevalence, risk factors, and impact on food choices. Neurogastroenterology and Motility, 27(8): 1138-1146.
Toplam 55 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Ceren Akal

Atilla Yetişmeyen

Yayımlanma Tarihi 15 Ocak 2020
Yayımlandığı Sayı Yıl 2020

Kaynak Göster

APA Akal, C., & Yetişmeyen, A. (2020). PROBİYOTİK VE PREBİYOTİK TÜKETİMİNİN LAKTOZ İNTOLERANSI ÜZERİNE ETKİLERİ. Gıda, 45(2), 380-389. https://doi.org/10.15237/gida.GD20016
AMA Akal C, Yetişmeyen A. PROBİYOTİK VE PREBİYOTİK TÜKETİMİNİN LAKTOZ İNTOLERANSI ÜZERİNE ETKİLERİ. GIDA. Ocak 2020;45(2):380-389. doi:10.15237/gida.GD20016
Chicago Akal, Ceren, ve Atilla Yetişmeyen. “PROBİYOTİK VE PREBİYOTİK TÜKETİMİNİN LAKTOZ İNTOLERANSI ÜZERİNE ETKİLERİ”. Gıda 45, sy. 2 (Ocak 2020): 380-89. https://doi.org/10.15237/gida.GD20016.
EndNote Akal C, Yetişmeyen A (01 Ocak 2020) PROBİYOTİK VE PREBİYOTİK TÜKETİMİNİN LAKTOZ İNTOLERANSI ÜZERİNE ETKİLERİ. Gıda 45 2 380–389.
IEEE C. Akal ve A. Yetişmeyen, “PROBİYOTİK VE PREBİYOTİK TÜKETİMİNİN LAKTOZ İNTOLERANSI ÜZERİNE ETKİLERİ”, GIDA, c. 45, sy. 2, ss. 380–389, 2020, doi: 10.15237/gida.GD20016.
ISNAD Akal, Ceren - Yetişmeyen, Atilla. “PROBİYOTİK VE PREBİYOTİK TÜKETİMİNİN LAKTOZ İNTOLERANSI ÜZERİNE ETKİLERİ”. Gıda 45/2 (Ocak 2020), 380-389. https://doi.org/10.15237/gida.GD20016.
JAMA Akal C, Yetişmeyen A. PROBİYOTİK VE PREBİYOTİK TÜKETİMİNİN LAKTOZ İNTOLERANSI ÜZERİNE ETKİLERİ. GIDA. 2020;45:380–389.
MLA Akal, Ceren ve Atilla Yetişmeyen. “PROBİYOTİK VE PREBİYOTİK TÜKETİMİNİN LAKTOZ İNTOLERANSI ÜZERİNE ETKİLERİ”. Gıda, c. 45, sy. 2, 2020, ss. 380-9, doi:10.15237/gida.GD20016.
Vancouver Akal C, Yetişmeyen A. PROBİYOTİK VE PREBİYOTİK TÜKETİMİNİN LAKTOZ İNTOLERANSI ÜZERİNE ETKİLERİ. GIDA. 2020;45(2):380-9.

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