KETOJENİK BESLENME VE SAĞLIK

Yıl 2022, Cilt: 5 Sayı: 2, 317 - 345, 30.09.2022

Ceren Filiz , Elif Yıldız , Ozan Gürbüz

https://doi.org/10.52538/iduhes.1093564

Öz

Ketojenik diyet (KD), keton cisimlerinin üretimini teşvik etmek amacıyla açlık durumunun metabolizmasını taklit eden yüksek yağlı, yeterli proteinli ve çok düşük karbonhidratlı bir diyet rejimidir. KD, epilepsi tedavisi için uzun süredir oldukça başarılı bir diyet yaklaşımı olarak öne çıkmaktadır. Son verilere göre KD’nin teröpotik etkisi, epilepsinin yanısıra kanser, diyabet, obezite gibi birçok hastalık için umut vadedici görünmektedir. Hatta kilo vermeye ihtiyacı olmayan bireyler arasında bile bu diyetin popüler olarak uygulanması göz önüne alındığında, nüfusun geniş kesimleri tarafından bu diyetin geniş bir şekilde benimsenmesinin potansiyel uzun vadeli sonuçlarıyla ilgili bazı endişeler oluşmaktadır. Bu derlemede, KD ve KD ile ilgili olarak öne çıkan kavramlara yer verilmiş olup, farklı hastalıklarda KD'nin etkililiği ve güvenilirliğine ilişkin deneysel ve/veya klinik veriler özetlenmiştir. KD'nin hücresel ve moleküler düzeydeki anlaşılan etkilerinin olası mekanizmaları tartışılarak, daha fazla açıklığa kavuşturulması gereken çoklu mekanizmaların olabileceği vurgulanmıştır. KD’nin terapötik etkileri ve etki mekanizmalarına dair bilimsel veriler yetersiz olup, KD'nin klinik uygulamasının yaygınlaştırılabilmesi için daha fazla çalışmaya ihtiyaç duyulmaktadır.

Anahtar Kelimeler

ketojenik diyet, yağ, karbonhidrat, keton

Destekleyen Kurum

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Proje Numarası

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Teşekkür

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Ketogenic Nutrition and Health

Öz

The ketogenic diet (KD) is a high-fat, adequate-protein and very low-carb diet regimen that simulates/mimics the metabolism of the fasting state to stimulate the production of ketone bodies. KD has long stood out as a highly successful dietary approach for the treatment of epilepsy. According to the latest data, the therapeutic effect of KD seems promising for many diseases such as cancer, diabetes, obesity as well as epilepsy. Given the widespread practice of this diet, even among individuals who do not need to lose weight, there is some concern about the potential long-term consequences of widespread adoption of this diet by large sections of the population. In this review, prominent concepts related to KD and the KD are expressed, and experimental and/or clinical data on the efficacy and safety of KD in different diseases are summarized. The possible mechanisms of the understood effects of KD at the cellular and molecular level were discussed, emphasizing that there may be multiple mechanisms that need further clarification. Scientific data on the therapeutic effects and mechanisms of action of KD are insufficient, and more studies are required in order to expand the clinical application of KD.

Anahtar Kelimeler

ketogenic diet, fat, carbs, ketone

Proje Numarası

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Kaynakça

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